Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study
Question: We evaluated whether the time between frst respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Pat...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/186115 |
| Acceso en línea: | https://hdl.handle.net/2445/186115 |
| Access Level: | acceso abierto |
| Palabra clave: | COVID-19 Síndrome del destret respiratori de l'adult Malalts en estat crític Intubació Malalties del pulmó Adult respiratory distress syndrome Critically ill Intubation Pulmonary diseases |
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Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort studyGonzález, JessicaBenítez, Iván D.Gonzalo-Calvo, David deTorres, GerardBatlle, Jordi deGómez, SilviaMoncusí Moix, AnnaCarmona, PaolaSantisteve, SallyMonge, AidaGort Paniello, ClaraZuil, MaríaCabo Gambín, RamónManzano, Senra, CarlosVengoechea Aragoncillo, José JavierVaca, RafaelaMinguez, OlgaAguilar Cabello, MaríaFerrer Roca, RicardCeccato, AdrianFernández Barat, LaiaMotos, AnaRiera, JordiMenéndez, RosarioGarcía Gasulla, DarioPeñuelas, OscarLabarca, GonzaloCaballero, JesúsBarberà, CarmeTorres Martí, AntoniBarbé, FerranCIBERESUCICOVID Project (COV20/00110, ISCIII)COVID-19Síndrome del destret respiratori de l'adultMalalts en estat críticIntubacióMalalties del pulmóCOVID-19Adult respiratory distress syndromeCritically illIntubationPulmonary diseasesQuestion: We evaluated whether the time between frst respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Patients were classifed as early intubation if they were intubated within the frst 48 h from the frst respiratory support or delayed intubation if they were intubated later. Surviving patients were evaluated after hospital discharge. Results: We included 205 patients (140 with early IMV and 65 with delayed IMV). The median [p25;p75] age was 63 [56.0; 70.0] years, and 74.1% were male. The survival analysis showed a signifcant increase in the risk of mortality in the delayed group with an adjusted hazard ratio (HR) of 2.45 (95% CI 1.29-4.65). The continuous predictor time to IMV showed a nonlinear association with the risk of in-hospital mortality. A multivariate mortality model showed that delay of IMV was a factor associated with mortality (HR of 2.40; 95% CI 1.42-4.1). During follow-up, patients in the delayed group showed a worse DLCO (mean diference of −10.77 (95% CI −18.40 to −3.15), with a greater number of afected lobes (+1.51 [95% CI 0.89-2.13]) and a greater TSS (+4.35 [95% CI 2.41-6.27]) in the chest CT scan. Conclusions: Among critically ill patients with COVID-19 who required IMV, the delay in intubation from the frst respiratory support was associated with an increase in hospital mortality and worse pulmonary sequelae during follow-up. Keywords: COVID-19, ARDS, Critically ill patients, Early intubation, Respiratory management, Pulmonary sequelaeBioMed Central2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/186115Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13054-021-03882-1Critical Care, 2022, vol. 26, num. 1, p. 18-28https://doi.org/10.1186/s13054-021-03882-1cc-by (c) González, Jessica et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1861152026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| title |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| spellingShingle |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study González, Jessica COVID-19 Síndrome del destret respiratori de l'adult Malalts en estat crític Intubació Malalties del pulmó COVID-19 Adult respiratory distress syndrome Critically ill Intubation Pulmonary diseases |
| title_short |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| title_full |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| title_fullStr |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| title_full_unstemmed |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| title_sort |
Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study |
| dc.creator.none.fl_str_mv |
González, Jessica Benítez, Iván D. Gonzalo-Calvo, David de Torres, Gerard Batlle, Jordi de Gómez, Silvia Moncusí Moix, Anna Carmona, Paola Santisteve, Sally Monge, Aida Gort Paniello, Clara Zuil, María Cabo Gambín, Ramón Manzano, Senra, Carlos Vengoechea Aragoncillo, José Javier Vaca, Rafaela Minguez, Olga Aguilar Cabello, María Ferrer Roca, Ricard Ceccato, Adrian Fernández Barat, Laia Motos, Ana Riera, Jordi Menéndez, Rosario García Gasulla, Dario Peñuelas, Oscar Labarca, Gonzalo Caballero, Jesús Barberà, Carme Torres Martí, Antoni Barbé, Ferran CIBERESUCICOVID Project (COV20/00110, ISCIII) |
| author |
González, Jessica |
| author_facet |
González, Jessica Benítez, Iván D. Gonzalo-Calvo, David de Torres, Gerard Batlle, Jordi de Gómez, Silvia Moncusí Moix, Anna Carmona, Paola Santisteve, Sally Monge, Aida Gort Paniello, Clara Zuil, María Cabo Gambín, Ramón Manzano, Senra, Carlos Vengoechea Aragoncillo, José Javier Vaca, Rafaela Minguez, Olga Aguilar Cabello, María Ferrer Roca, Ricard Ceccato, Adrian Fernández Barat, Laia Motos, Ana Riera, Jordi Menéndez, Rosario García Gasulla, Dario Peñuelas, Oscar Labarca, Gonzalo Caballero, Jesús Barberà, Carme Torres Martí, Antoni Barbé, Ferran CIBERESUCICOVID Project (COV20/00110, ISCIII) |
| author_role |
author |
| author2 |
Benítez, Iván D. Gonzalo-Calvo, David de Torres, Gerard Batlle, Jordi de Gómez, Silvia Moncusí Moix, Anna Carmona, Paola Santisteve, Sally Monge, Aida Gort Paniello, Clara Zuil, María Cabo Gambín, Ramón Manzano, Senra, Carlos Vengoechea Aragoncillo, José Javier Vaca, Rafaela Minguez, Olga Aguilar Cabello, María Ferrer Roca, Ricard Ceccato, Adrian Fernández Barat, Laia Motos, Ana Riera, Jordi Menéndez, Rosario García Gasulla, Dario Peñuelas, Oscar Labarca, Gonzalo Caballero, Jesús Barberà, Carme Torres Martí, Antoni Barbé, Ferran CIBERESUCICOVID Project (COV20/00110, ISCIII) |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
COVID-19 Síndrome del destret respiratori de l'adult Malalts en estat crític Intubació Malalties del pulmó COVID-19 Adult respiratory distress syndrome Critically ill Intubation Pulmonary diseases |
| topic |
COVID-19 Síndrome del destret respiratori de l'adult Malalts en estat crític Intubació Malalties del pulmó COVID-19 Adult respiratory distress syndrome Critically ill Intubation Pulmonary diseases |
| description |
Question: We evaluated whether the time between frst respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Patients were classifed as early intubation if they were intubated within the frst 48 h from the frst respiratory support or delayed intubation if they were intubated later. Surviving patients were evaluated after hospital discharge. Results: We included 205 patients (140 with early IMV and 65 with delayed IMV). The median [p25;p75] age was 63 [56.0; 70.0] years, and 74.1% were male. The survival analysis showed a signifcant increase in the risk of mortality in the delayed group with an adjusted hazard ratio (HR) of 2.45 (95% CI 1.29-4.65). The continuous predictor time to IMV showed a nonlinear association with the risk of in-hospital mortality. A multivariate mortality model showed that delay of IMV was a factor associated with mortality (HR of 2.40; 95% CI 1.42-4.1). During follow-up, patients in the delayed group showed a worse DLCO (mean diference of −10.77 (95% CI −18.40 to −3.15), with a greater number of afected lobes (+1.51 [95% CI 0.89-2.13]) and a greater TSS (+4.35 [95% CI 2.41-6.27]) in the chest CT scan. Conclusions: Among critically ill patients with COVID-19 who required IMV, the delay in intubation from the frst respiratory support was associated with an increase in hospital mortality and worse pulmonary sequelae during follow-up. Keywords: COVID-19, ARDS, Critically ill patients, Early intubation, Respiratory management, Pulmonary sequelae |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/186115 |
| url |
https://hdl.handle.net/2445/186115 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03882-1 Critical Care, 2022, vol. 26, num. 1, p. 18-28 https://doi.org/10.1186/s13054-021-03882-1 |
| dc.rights.none.fl_str_mv |
cc-by (c) González, Jessica et al., 2022 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) González, Jessica et al., 2022 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
11 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869410034353438720 |
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15.812429 |