Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study

Question: We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Pa...

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Detalles Bibliográficos
Autores: González, Jessica, Benítez, Iván, de Gonzalo Calvo, David, Torres, Gerard, Batlle Garcia, Jordi de, Gómez Falguera, Silvia, Moncusí Moix, Anna, Carmona, Paola, Santisteve, Sally, Monge Esqué, Aida, Gort Paniello, Clara, Zuil, María, Cabo Gambín, Ramón, Manzano Senra, Carlos, Vengoechea Aragoncillo, José Javier, Vaca, Rafaela, Minguez Roure, Olga, Aguilar, María, Ferrer, Ricard, Ceccato, Adrián, Fernández Barat, Laia, Motos, Anna, Riera, Jordi, Menéndez, Rosario, García Gasulla, Darío, Peñuelas, Oscar, Labarca, Gonzalo, Caballero, Jesús, Barberà, Carme, Torres, Antoni, Barbé Illa, Ferran
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/73137
Acceso en línea:https://doi.org/10.1186/s13054-021-03882-1
http://hdl.handle.net/10459.1/73137
Access Level:acceso abierto
Palabra clave:ARDS
COVID-19
Critically ill patients
Early intubation
Pulmonary sequelae
Respiratory management
Descripción
Sumario:Question: We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Patients were classified as early intubation if they were intubated within the first 48 h from the first respiratory support or delayed intubation if they were intubated later. Surviving patients were evaluated after hospital discharge. Results: We included 205 patients (140 with early IMV and 65 with delayed IMV). The median [p25;p75] age was 63 [56.0; 70.0] years, and 74.1% were male. The survival analysis showed a significant increase in the risk of mortality in the delayed group with an adjusted hazard ratio (HR) of 2.45 (95% CI 1.29-4.65). The continuous predictor time to IMV showed a nonlinear association with the risk of in-hospital mortality. A multivariate mortality model showed that delay of IMV was a factor associated with mortality (HR of 2.40; 95% CI 1.42-4.1). During follow-up, patients in the delayed group showed a worse DLCO (mean difference of - 10.77 (95% CI - 18.40 to - 3.15), with a greater number of affected lobes (+ 1.51 [95% CI 0.89-2.13]) and a greater TSS (+ 4.35 [95% CI 2.41-6.27]) in the chest CT scan. Conclusions: Among critically ill patients with COVID-19 who required IMV, the delay in intubation from the first respiratory support was associated with an increase in hospital mortality and worse pulmonary sequelae during follow-up.

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