Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile

Backgrounds and aim: To prospectively evaluate the associations between changes in (poly)phenol intake, body weight(BW), and physical activity(PA) with changes in an inflammatory score after 1-year. Methods and results: This is a prospective observational analysis involving 484 participants from the...

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Autores: Rubín-García, M, Vitelli-Storelli, F, Alvarez-Alvarez, L, Fitó, M, Vázquez-Ruiz, Z, Salas-Salvadó, J, Corella, D, Serra-Majem, L, Warnberg, J, Romaguera, D, Estruch, R, Pintó, X, Martínez, JA, Vázquez, C, Vidal, J, Tur, JA, Alonso-Gómez, AM, Ros, E, Vioque, J, López-Miranda, J, Bueno-Cavanillas, A, Tinahones, FJ, Lapetra, J, Daimiel, L, Delgado-Rodríguez, M, Matía-Martín, P, Babio, N, Schröder, H, Lamuela-Raventós, RM, Martin-Sánchez, V, Zamora-Ros, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11222
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11222
https://doi.org/10.1016/j.numecd.2024.103837
Access Level:acceso abierto
Palabra clave:(Poly)phenols
body weight
Physical activity
Inflammation
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spelling Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profileRubín-García, MVitelli-Storelli, FAlvarez-Alvarez, LFitó, MVázquez-Ruiz, ZSalas-Salvadó, JCorella, DSerra-Majem, LWarnberg, JRomaguera, DEstruch, RPintó, XMartínez, JAVázquez, CVidal, JTur, JAAlonso-Gómez, AMRos, EVioque, JLópez-Miranda, JBueno-Cavanillas, ATinahones, FJLapetra, JDaimiel, LDelgado-Rodríguez, MMatía-Martín, PBabio, NSchröder, HLamuela-Raventós, RMMartin-Sánchez, VZamora-Ros, R(Poly)phenolsbody weightPhysical activityInflammationBackgrounds and aim: To prospectively evaluate the associations between changes in (poly)phenol intake, body weight(BW), and physical activity(PA) with changes in an inflammatory score after 1-year. Methods and results: This is a prospective observational analysis involving 484 participants from the PREDIMEDPlus with available inflammatory measurements. (Poly)phenol intake was estimated using a validated semi- quantitative food frequency questionnaire and the Phenol-Explorer database. An inflammatory score was calculated based on 8 blood biomarkers (IL-6, IL-8, IL-18, MCP-1, C-peptide, hs-CRP, leptin, and RANTES). The association between BW, PA, (poly)phenol intake and inflammatory score was evaluated using structural equations. Mediation analyses were performed to assess the relationship between change in (poly)phenol intake and inflammatory score was mediated by the change in BW. A higher increase in total (poly)phenol intake was related to a decrease in the inflammatory score ((3 =- 0.005mg/1000 Kcal; CI95 % =-0.100,0.000) along with a decrease in BW ((3 =- 0.006mg/1000 Kcal; CI95 % =-0.010,-0.003). Increased PA was associated with a lower inflammatory score ((3 =- 0.129MET-min/d; CI95 % =-0.238,-0.021) and BW ((3 =- 0.248MET-min/d; CI95 % =-0.343,-0.152). Finally, a decrease in BW was associated with a decrease in the inflammatory score ((3 = 0.240 kg; CI95 % = 0.155,0.325). Mediation analyses revealed that changes in BW explained 22 % of the overall association between changes in (poly)phenol intake and inflammatory score. Conclusions: An inverse association between changes in (poly)phenol intake and inflammatory status was observed, with BW playing a significant mediating role, emphasising the impact of BW reduction on inflammation reduction.ELSEVIER SCI LTD2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones11222https://doi.org/10.1016/j.numecd.2024.103837NUTRITION METABOLISM AND CARDIOVASCULAR DISEASESISSN: 09394753ISSNe: 15903729reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p112222026-06-12T10:20:37Z
dc.title.none.fl_str_mv Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
title Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
spellingShingle Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
Rubín-García, M
(Poly)phenols
body weight
Physical activity
Inflammation
title_short Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
title_full Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
title_fullStr Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
title_full_unstemmed Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
title_sort Prospective association of changes in (poly)phenol intake, body weight and physical activity with inflammatory profile
dc.creator.none.fl_str_mv Rubín-García, M
Vitelli-Storelli, F
Alvarez-Alvarez, L
Fitó, M
Vázquez-Ruiz, Z
Salas-Salvadó, J
Corella, D
Serra-Majem, L
Warnberg, J
Romaguera, D
Estruch, R
Pintó, X
Martínez, JA
Vázquez, C
Vidal, J
Tur, JA
Alonso-Gómez, AM
Ros, E
Vioque, J
López-Miranda, J
Bueno-Cavanillas, A
Tinahones, FJ
Lapetra, J
Daimiel, L
Delgado-Rodríguez, M
Matía-Martín, P
Babio, N
Schröder, H
Lamuela-Raventós, RM
Martin-Sánchez, V
Zamora-Ros, R
author Rubín-García, M
author_facet Rubín-García, M
Vitelli-Storelli, F
Alvarez-Alvarez, L
Fitó, M
Vázquez-Ruiz, Z
Salas-Salvadó, J
Corella, D
Serra-Majem, L
Warnberg, J
Romaguera, D
Estruch, R
Pintó, X
Martínez, JA
Vázquez, C
Vidal, J
Tur, JA
Alonso-Gómez, AM
Ros, E
Vioque, J
López-Miranda, J
Bueno-Cavanillas, A
Tinahones, FJ
Lapetra, J
Daimiel, L
Delgado-Rodríguez, M
Matía-Martín, P
Babio, N
Schröder, H
Lamuela-Raventós, RM
Martin-Sánchez, V
Zamora-Ros, R
author_role author
author2 Vitelli-Storelli, F
Alvarez-Alvarez, L
Fitó, M
Vázquez-Ruiz, Z
Salas-Salvadó, J
Corella, D
Serra-Majem, L
Warnberg, J
Romaguera, D
Estruch, R
Pintó, X
Martínez, JA
Vázquez, C
Vidal, J
Tur, JA
Alonso-Gómez, AM
Ros, E
Vioque, J
López-Miranda, J
Bueno-Cavanillas, A
Tinahones, FJ
Lapetra, J
Daimiel, L
Delgado-Rodríguez, M
Matía-Martín, P
Babio, N
Schröder, H
Lamuela-Raventós, RM
Martin-Sánchez, V
Zamora-Ros, R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv (Poly)phenols
body weight
Physical activity
Inflammation
topic (Poly)phenols
body weight
Physical activity
Inflammation
description Backgrounds and aim: To prospectively evaluate the associations between changes in (poly)phenol intake, body weight(BW), and physical activity(PA) with changes in an inflammatory score after 1-year. Methods and results: This is a prospective observational analysis involving 484 participants from the PREDIMEDPlus with available inflammatory measurements. (Poly)phenol intake was estimated using a validated semi- quantitative food frequency questionnaire and the Phenol-Explorer database. An inflammatory score was calculated based on 8 blood biomarkers (IL-6, IL-8, IL-18, MCP-1, C-peptide, hs-CRP, leptin, and RANTES). The association between BW, PA, (poly)phenol intake and inflammatory score was evaluated using structural equations. Mediation analyses were performed to assess the relationship between change in (poly)phenol intake and inflammatory score was mediated by the change in BW. A higher increase in total (poly)phenol intake was related to a decrease in the inflammatory score ((3 =- 0.005mg/1000 Kcal; CI95 % =-0.100,0.000) along with a decrease in BW ((3 =- 0.006mg/1000 Kcal; CI95 % =-0.010,-0.003). Increased PA was associated with a lower inflammatory score ((3 =- 0.129MET-min/d; CI95 % =-0.238,-0.021) and BW ((3 =- 0.248MET-min/d; CI95 % =-0.343,-0.152). Finally, a decrease in BW was associated with a decrease in the inflammatory score ((3 = 0.240 kg; CI95 % = 0.155,0.325). Mediation analyses revealed that changes in BW explained 22 % of the overall association between changes in (poly)phenol intake and inflammatory score. Conclusions: An inverse association between changes in (poly)phenol intake and inflammatory status was observed, with BW playing a significant mediating role, emphasising the impact of BW reduction on inflammation reduction.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones11222
https://doi.org/10.1016/j.numecd.2024.103837
url https://isabial.portalinvestigacion.com/publicaciones11222
https://doi.org/10.1016/j.numecd.2024.103837
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
ISSN: 09394753
ISSNe: 15903729
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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