Efficacy of cognitive rehabilitation in cognition and brain networks
This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer® (GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward in...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:319531 |
| Acceso en línea: | https://ddd.uab.cat/record/319531 https://dx.doi.org/urn:doi:10.1016/j.nicl.2025.103775 |
| Access Level: | acceso abierto |
| Palabra clave: | Cognition Cognitive rehabilitation MRI Multiple sclerosis Structural networks |
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oai:ddd.uab.cat:319531 |
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España |
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| dc.title.none.fl_str_mv |
Efficacy of cognitive rehabilitation in cognition and brain networks A randomised clinical trial in patients with multiple sclerosis |
| title |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| spellingShingle |
Efficacy of cognitive rehabilitation in cognition and brain networks Lopez-Soley, Elisabet Cognition Cognitive rehabilitation MRI Multiple sclerosis Structural networks |
| title_short |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| title_full |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| title_fullStr |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| title_full_unstemmed |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| title_sort |
Efficacy of cognitive rehabilitation in cognition and brain networks |
| dc.creator.none.fl_str_mv |
Lopez-Soley, Elisabet Martinez-Heras, Eloy|||0000-0001-9937-3162 Vivó Pascual, Francesc|||0000-0002-6409-1197 Calvi, Alberto|||0000-0002-1953-2803 Alba-Arbalat, Salut|||0000-0003-1662-2317 Romero Pinel, Lucía|||0000-0001-8054-0565 Martínez Yélamos, Sergio|||0000-0001-9889-2040 Ramo-Tello, Cristina|||0000-0001-8643-5053 Presas Rodríguez, Sílvia|||0000-0001-8545-2476 Munteis, Elvira|||0000-0002-6195-9106 Martínez-Rodríguez, José Enrique Sastre-Garriga, Jaume|||0000-0002-1589-2254 Anglada, E.|||0000-0001-5074-4970 Meza-Murillo, Edwin Roger|||0000-0001-6065-3546 Arévalo, María Jesús|||0000-0003-0626-5555 Sánchez Carrión, Rocío Pelayo, Raúl|||0000-0002-1313-0686 Bernabeu Guitart, Montserrat|||0000-0003-2037-3069 Sola-Valls, Nuria Hervas, M. Sepúlveda, María Saiz, Albert|||0000-0002-5793-8791 Blanco Morgado, Yolanda|||0000-0002-1834-0498 Solana, Elisabeth|||0000-0001-7973-2439 Llufriu, Sara|||0000-0003-4273-9121 |
| author |
Lopez-Soley, Elisabet |
| author_facet |
Lopez-Soley, Elisabet Martinez-Heras, Eloy|||0000-0001-9937-3162 Vivó Pascual, Francesc|||0000-0002-6409-1197 Calvi, Alberto|||0000-0002-1953-2803 Alba-Arbalat, Salut|||0000-0003-1662-2317 Romero Pinel, Lucía|||0000-0001-8054-0565 Martínez Yélamos, Sergio|||0000-0001-9889-2040 Ramo-Tello, Cristina|||0000-0001-8643-5053 Presas Rodríguez, Sílvia|||0000-0001-8545-2476 Munteis, Elvira|||0000-0002-6195-9106 Martínez-Rodríguez, José Enrique Sastre-Garriga, Jaume|||0000-0002-1589-2254 Anglada, E.|||0000-0001-5074-4970 Meza-Murillo, Edwin Roger|||0000-0001-6065-3546 Arévalo, María Jesús|||0000-0003-0626-5555 Sánchez Carrión, Rocío Pelayo, Raúl|||0000-0002-1313-0686 Bernabeu Guitart, Montserrat|||0000-0003-2037-3069 Sola-Valls, Nuria Hervas, M. Sepúlveda, María Saiz, Albert|||0000-0002-5793-8791 Blanco Morgado, Yolanda|||0000-0002-1834-0498 Solana, Elisabeth|||0000-0001-7973-2439 Llufriu, Sara|||0000-0003-4273-9121 |
| author_role |
author |
| author2 |
Martinez-Heras, Eloy|||0000-0001-9937-3162 Vivó Pascual, Francesc|||0000-0002-6409-1197 Calvi, Alberto|||0000-0002-1953-2803 Alba-Arbalat, Salut|||0000-0003-1662-2317 Romero Pinel, Lucía|||0000-0001-8054-0565 Martínez Yélamos, Sergio|||0000-0001-9889-2040 Ramo-Tello, Cristina|||0000-0001-8643-5053 Presas Rodríguez, Sílvia|||0000-0001-8545-2476 Munteis, Elvira|||0000-0002-6195-9106 Martínez-Rodríguez, José Enrique Sastre-Garriga, Jaume|||0000-0002-1589-2254 Anglada, E.|||0000-0001-5074-4970 Meza-Murillo, Edwin Roger|||0000-0001-6065-3546 Arévalo, María Jesús|||0000-0003-0626-5555 Sánchez Carrión, Rocío Pelayo, Raúl|||0000-0002-1313-0686 Bernabeu Guitart, Montserrat|||0000-0003-2037-3069 Sola-Valls, Nuria Hervas, M. Sepúlveda, María Saiz, Albert|||0000-0002-5793-8791 Blanco Morgado, Yolanda|||0000-0002-1834-0498 Solana, Elisabeth|||0000-0001-7973-2439 Llufriu, Sara|||0000-0003-4273-9121 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cognition Cognitive rehabilitation MRI Multiple sclerosis Structural networks |
| topic |
Cognition Cognitive rehabilitation MRI Multiple sclerosis Structural networks |
| description |
This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer® (GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre- and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 ± 8.8, disease duration 16.8 ± 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and -17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/319531 https://dx.doi.org/urn:doi:10.1016/j.nicl.2025.103775 |
| url |
https://ddd.uab.cat/record/319531 https://dx.doi.org/urn:doi:10.1016/j.nicl.2025.103775 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00944 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00002 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00950 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00750 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01634 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 FI16/00251 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01030 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/01189 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0015/0002 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0015/0003 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Efficacy of cognitive rehabilitation in cognition and brain networksA randomised clinical trial in patients with multiple sclerosisLopez-Soley, ElisabetMartinez-Heras, Eloy|||0000-0001-9937-3162Vivó Pascual, Francesc|||0000-0002-6409-1197Calvi, Alberto|||0000-0002-1953-2803Alba-Arbalat, Salut|||0000-0003-1662-2317Romero Pinel, Lucía|||0000-0001-8054-0565Martínez Yélamos, Sergio|||0000-0001-9889-2040Ramo-Tello, Cristina|||0000-0001-8643-5053Presas Rodríguez, Sílvia|||0000-0001-8545-2476Munteis, Elvira|||0000-0002-6195-9106Martínez-Rodríguez, José EnriqueSastre-Garriga, Jaume|||0000-0002-1589-2254Anglada, E.|||0000-0001-5074-4970Meza-Murillo, Edwin Roger|||0000-0001-6065-3546Arévalo, María Jesús|||0000-0003-0626-5555Sánchez Carrión, RocíoPelayo, Raúl|||0000-0002-1313-0686Bernabeu Guitart, Montserrat|||0000-0003-2037-3069Sola-Valls, NuriaHervas, M.Sepúlveda, MaríaSaiz, Albert|||0000-0002-5793-8791Blanco Morgado, Yolanda|||0000-0002-1834-0498Solana, Elisabeth|||0000-0001-7973-2439Llufriu, Sara|||0000-0003-4273-9121CognitionCognitive rehabilitationMRIMultiple sclerosisStructural networksThis study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer® (GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre- and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 ± 8.8, disease duration 16.8 ± 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and -17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.Universitat Autònoma de Barcelona 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/319531https://dx.doi.org/urn:doi:10.1016/j.nicl.2025.103775reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00944Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00002Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00950Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00750Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01634Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 FI16/00251Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01030Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/01189Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0015/0002Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0015/0003open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3195312026-06-06T12:50:31Z |
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15,81155 |