Efficacy of cognitive rehabilitation in cognition and brain networks: A randomised clinical trial in patients with multiple sclerosis

This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward...

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Detalles Bibliográficos
Autores: Lopez-Soley, E, Martinez-Heras, E, Vivo, F, Calvi, A, Alba-Arbalat, S, Romero-Pinel, L, Martínez-Yélamos, S, Ramo-Tello, C, Presas-Rodríguez, S, Munteis, E, Martínez-Rodríguez, JE, Sastre-Garriga, J, Anglada, E, Meza-Murillo, ER, Arévalo, MJ, Sanchez-Carrión, R, Pelayo, R, Bernabeu, M, Sola-Valls, N, Hervas, M, Sepulveda, M, Saiz, A, Blanco, Y, Solana, E, Llufriu, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6320
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6320
Access Level:acceso abierto
Palabra clave:Cognitive rehabilitation
Cognition
MRI
Structural networks
Multiple sclerosis
Descripción
Sumario:This study evaluated the efficacy of the computerised Guttmann, NeuroPersonalTrainer (R)(GNPT) cognitive rehabilitation (CR) and characterised the induced changes in cerebral networks in patients with multiple sclerosis (MS). This multicentre, double-blind, randomised clinical trial compared upward intensity training (active treatment) to low-intensity static training (static treatment). Cognition was assessed using the Brief Repeatable battery before and after 12 weeks of training and at 10-months follow-up, and patients were classified as having a mild or severe cognitive impairment (CI). Brain MRI pre-and post-CR were analysed using an advanced tractography algorithm, based on multishell diffusion MRI, to obtain node-based graph metrics (local efficiency and strength) from microscopic fractional anisotropy. Seventy MS patients completed the study (age 48.9 +/- 8.8, disease duration 16.8 +/- 9.0 years); active treatment: 36, static treatment: 34. Verbal memory improved significantly post-CR in both groups (55 % active; 34 % static treatment), accompanied by increases in local efficiency and strength in multimodal regions. At follow-up, verbal memory declined in both groups but remained above the pre-CR assessment (-25 % and-17 %, respectively). Patients with severe-CI (n = 36) showed improvement only with active treatment, while those with mild-CI (n = 34) improved regardless of intensity treatment. Network changes were more pronounced in patients in active treatment and in those with severe-CI. Quality of life did not change at post-CR, and cognitive improvement was influenced by cognitive reserve (p = 0.011). In MS, GNPT temporarily improves verbal memory and increases network connectivity, reinforcing the CR as a valuable tool for enhancing cognitive skills and promoting neuronal plasticity.

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