Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]

Albiñana, Virginia; Sarro Miguel, Clara; Lorente-Herraiz, Laura; Recio-Poveda, Lucía; Cuesta, Angel; Viñas-López, Jesús; Aguirre, Daniel T.; Ruiz-Llorente, Lidia; Botella, Luisa María

Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]

Data are expressed as means ± standard deviation (SD) and each experiment was repeated at least 3 times. Statistical analyses were performed using Student’s t-test for comparisons between two groups and two-way ANOVA followed by Tukey’s multiple comparisons test for analyses involving two independen...

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Detalhes bibliográficos
Autores:	Albiñana, Virginia, Sarro Miguel, Clara, Lorente-Herraiz, Laura, Recio-Poveda, Lucía, Cuesta, Angel, Viñas-López, Jesús, Aguirre, Daniel T., Ruiz-Llorente, Lidia, Botella, Luisa María
Formato:	conjunto de datos
Fecha de publicación:	2025
País:	España
Recursos:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/404398
Acesso em linha:	http://hdl.handle.net/10261/404398 https://doi.org/10.20350/digitalCSIC/17678
Access Level:	acceso abierto
Palavra-chave:	von Hippel-Lindau Hemangioblastoma ccRCC Adrenergic receptor CHEK2 ICI- 118,551 Olaparib Personalized medicine

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spelling	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]Albiñana, VirginiaSarro Miguel, ClaraLorente-Herraiz, LauraRecio-Poveda, LucíaCuesta, AngelViñas-López, JesúsAguirre, Daniel T.Ruiz-Llorente, LidiaBotella, Luisa Maríavon Hippel-LindauHemangioblastomaccRCCAdrenergic receptorCHEK2ICI- 118,551OlaparibPersonalized medicineData are expressed as means ± standard deviation (SD) and each experiment was repeated at least 3 times. Statistical analyses were performed using Student’s t-test for comparisons between two groups and two-way ANOVA followed by Tukey’s multiple comparisons test for analyses involving two independent variables (performed using GraphPad Prism version 8.0.1). The normality and homogeneity of variances were verified before applying parametric tests. Differences were considered statistically significant at p < 0.05, with significance levels indicated as follows: p < 0.05, p < 0.01, p < 0.001, and p < 0.0001. RT-qPCR and Western Blot Fig 3B, S1, and the commercial CellTiter Glo Luminescent Cell Viability Assay kit (Promega) for Fig4B and S2Peer reviewedConsejo Superior de Investigaciones Científicas (España)Botella, Luisa MaríaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1txt/xlshttp://hdl.handle.net/10261/404398https://doi.org/10.20350/digitalCSIC/17678reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)EspañolInglésExcelSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4043982026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
title	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
spellingShingle	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET] Albiñana, Virginia von Hippel-Lindau Hemangioblastoma ccRCC Adrenergic receptor CHEK2 ICI- 118,551 Olaparib Personalized medicine
title_short	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
title_full	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
title_fullStr	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
title_full_unstemmed	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
title_sort	Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]
dc.creator.none.fl_str_mv	Albiñana, Virginia Sarro Miguel, Clara Lorente-Herraiz, Laura Recio-Poveda, Lucía Cuesta, Angel Viñas-López, Jesús Aguirre, Daniel T. Ruiz-Llorente, Lidia Botella, Luisa María
author	Albiñana, Virginia
author_facet	Albiñana, Virginia Sarro Miguel, Clara Lorente-Herraiz, Laura Recio-Poveda, Lucía Cuesta, Angel Viñas-López, Jesús Aguirre, Daniel T. Ruiz-Llorente, Lidia Botella, Luisa María
author_role	author
author2	Sarro Miguel, Clara Lorente-Herraiz, Laura Recio-Poveda, Lucía Cuesta, Angel Viñas-López, Jesús Aguirre, Daniel T. Ruiz-Llorente, Lidia Botella, Luisa María
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv	Botella, Luisa María Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	von Hippel-Lindau Hemangioblastoma ccRCC Adrenergic receptor CHEK2 ICI- 118,551 Olaparib Personalized medicine
topic	von Hippel-Lindau Hemangioblastoma ccRCC Adrenergic receptor CHEK2 ICI- 118,551 Olaparib Personalized medicine
description	Data are expressed as means ± standard deviation (SD) and each experiment was repeated at least 3 times. Statistical analyses were performed using Student’s t-test for comparisons between two groups and two-way ANOVA followed by Tukey’s multiple comparisons test for analyses involving two independent variables (performed using GraphPad Prism version 8.0.1). The normality and homogeneity of variances were verified before applying parametric tests. Differences were considered statistically significant at p < 0.05, with significance levels indicated as follows: p < 0.05, p < 0.01, p < 0.001, and p < 0.0001. RT-qPCR and Western Blot Fig 3B, S1, and the commercial CellTiter Glo Luminescent Cell Viability Assay kit (Promega) for Fig4B and S2
publishDate	2025
dc.date.none.fl_str_mv	2025 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/dataset http://purl.org/coar/resource_type/c_ddb1
format	dataset
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/404398 https://doi.org/10.20350/digitalCSIC/17678
url	http://hdl.handle.net/10261/404398 https://doi.org/10.20350/digitalCSIC/17678
dc.language.none.fl_str_mv	Español Inglés
language_invalid_str_mv	Español Inglés
dc.relation.none.fl_str_mv	Excel Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	txt/xls
dc.publisher.none.fl_str_mv	Consejo Superior de Investigaciones Científicas (España)
publisher.none.fl_str_mv	Consejo Superior de Investigaciones Científicas (España)
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Raw data and histograms of qPCR, used in the manuscript: Targeting Aggressive von Hippel Lindau Disease with a germinal mutation in the CHEK2 gene [DATASET]

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