Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer

The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition. However, its role in taxanes resistance has not been fully established. Gene expression of plasticity-related phenotypes such as epithelial-mesench...

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Detalhes bibliográficos
Autores: Jiménez, Natalia|||0000-0002-7057-0426, Reig, Oscar|||0000-0003-1166-6943, Montalbo, Ruth, Milà-Guasch, Maria, Nadal-Dieste, Lluis, Castellano, Giancarlo|||0000-0002-5715-7733, Lozano, Juan José, Victoria, Iván, Font, Albert|||0000-0003-3908-1111, Rodriguez-Vida, Alejo|||0000-0002-7304-6857, Carles, Joan|||0000-0002-9983-5934, Suárez, Cristina|||0000-0002-0502-5528, Domènech, Montserrat|||0000-0003-3973-0986, Sala-González, Núria, Fernández, Pedro Luis|||0000-0002-8618-4597, Rodríguez-Carunchio, Leonardo|||0000-0002-7019-554X, Diaz-Mercedes, Sherley|||0000-0002-8164-8639, Prat, Aleix|||0000-0003-2377-540X, Marín-Aguilera, Mercedes, Mellado, Begoña|||0000-0002-8088-5966
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253117
Acesso em linha:https://ddd.uab.cat/record/253117
https://dx.doi.org/urn:doi:10.3389/fonc.2020.594023
Access Level:acceso abierto
Palavra-chave:Cell plasticity
EMT-epithelial-mesenchymal transition
Neuroendocrine
Castration-resistant prostate cancer
Docetaxel
Cabazitaxel
Taxanes resistance
Descrição
Resumo:The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition. However, its role in taxanes resistance has not been fully established. Gene expression of plasticity-related phenotypes such as epithelial-mesenchymal transition (EMT), stem cell-like and neuroendocrine (NE) phenotypes was studied in vitro, in silico, in circulating tumor cells (CTCs) (N =22) and in tumor samples (N.

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