Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors

Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing...

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Autores: Montagut, Yeison, March Iborra, Mª Del Carmen, Montoya Baides, Ángel, García Narbón, José Vicente|||0000-0001-6303-8258, Jiménez Jiménez, Yolanda|||0000-0003-4835-9007, Arnau Vives, Antonio|||0000-0002-5709-1690
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/28829
Acceso en línea:https://riunet.upv.es/handle/10251/28829
Access Level:acceso abierto
Palabra clave:Acoustic biosensors
High fundamental frequency QCM
High resolution
Microbalance
Phase characterization
Sensitivity
Acoustics
Article
Genetic procedures
Instrumentation
Methodology
Quartz crystal microbalance
Biosensing Techniques
Quartz Crystal Microbalance Techniques
TECNOLOGIA ELECTRONICA
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spelling Validation of a Phase-Mass Characterization Concept and Interface for Acoustic BiosensorsMontagut, YeisonMarch Iborra, Mª Del CarmenMontoya Baides, ÁngelGarcía Narbón, José Vicente|||0000-0001-6303-8258Jiménez Jiménez, Yolanda|||0000-0003-4835-9007Arnau Vives, Antonio|||0000-0002-5709-1690Acoustic biosensorsHigh fundamental frequency QCMHigh resolutionMicrobalancePhase characterizationSensitivityAcousticsArticleGenetic proceduresInstrumentationMethodologyQuartz crystal microbalanceBiosensing TechniquesQuartz Crystal Microbalance TechniquesTECNOLOGIA ELECTRONICAAcoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: ¿¿/¿m ¿ -1/m L, where m L is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model. © 2011 by the authors; licensee MDPI, Basel, Switzerland.The authors are grateful to the Spanish Ministry of Science and Technology the financial support to this research under contract reference AGL2009-13511, and to the company Advanced Wave Sensors S.L. (www.awsensors.com) for the help provided in the development of some parts of this work.MDPIDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónCentro de Investigación e Innovación en BioingenieríaMinisterio de Ciencia e InnovaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/28829reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2009-13511 Inmunosensor Piezoelectrico De Alta Frecuencia Para La Deteccion De Bisfenol-A Y Ftalatos En Alimentos Envasadosopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/288292026-06-13T07:49:27Z
dc.title.none.fl_str_mv Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
title Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
spellingShingle Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
Montagut, Yeison
Acoustic biosensors
High fundamental frequency QCM
High resolution
Microbalance
Phase characterization
Sensitivity
Acoustics
Article
Genetic procedures
Instrumentation
Methodology
Quartz crystal microbalance
Biosensing Techniques
Quartz Crystal Microbalance Techniques
TECNOLOGIA ELECTRONICA
title_short Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
title_full Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
title_fullStr Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
title_full_unstemmed Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
title_sort Validation of a Phase-Mass Characterization Concept and Interface for Acoustic Biosensors
dc.creator.none.fl_str_mv Montagut, Yeison
March Iborra, Mª Del Carmen
Montoya Baides, Ángel
García Narbón, José Vicente|||0000-0001-6303-8258
Jiménez Jiménez, Yolanda|||0000-0003-4835-9007
Arnau Vives, Antonio|||0000-0002-5709-1690
author Montagut, Yeison
author_facet Montagut, Yeison
March Iborra, Mª Del Carmen
Montoya Baides, Ángel
García Narbón, José Vicente|||0000-0001-6303-8258
Jiménez Jiménez, Yolanda|||0000-0003-4835-9007
Arnau Vives, Antonio|||0000-0002-5709-1690
author_role author
author2 March Iborra, Mª Del Carmen
Montoya Baides, Ángel
García Narbón, José Vicente|||0000-0001-6303-8258
Jiménez Jiménez, Yolanda|||0000-0003-4835-9007
Arnau Vives, Antonio|||0000-0002-5709-1690
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Escuela Técnica Superior de Ingeniería de Telecomunicación
Centro de Investigación e Innovación en Bioingeniería
Ministerio de Ciencia e Innovación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Acoustic biosensors
High fundamental frequency QCM
High resolution
Microbalance
Phase characterization
Sensitivity
Acoustics
Article
Genetic procedures
Instrumentation
Methodology
Quartz crystal microbalance
Biosensing Techniques
Quartz Crystal Microbalance Techniques
TECNOLOGIA ELECTRONICA
topic Acoustic biosensors
High fundamental frequency QCM
High resolution
Microbalance
Phase characterization
Sensitivity
Acoustics
Article
Genetic procedures
Instrumentation
Methodology
Quartz crystal microbalance
Biosensing Techniques
Quartz Crystal Microbalance Techniques
TECNOLOGIA ELECTRONICA
description Acoustic wave resonator techniques are widely used in in-liquid biochemical applications. The main challenges remaining are the improvement of sensitivity and limit of detection, as well as multianalysis capabilities and reliability. The sensitivity improvement issue has been addressed by increasing the sensor frequency, using different techniques such as high fundamental frequency quartz crystal microbalances (QCMs), surface generated acoustic waves (SGAWs) and film bulk acoustic resonators (FBARs). However, this sensitivity improvement has not been completely matched in terms of limit of detection. The decrease on frequency stability due to the increase of the phase noise, particularly in oscillators, has made it impossible to increase the resolution. A new concept of sensor characterization at constant frequency has been recently proposed based on the phase/mass sensitivity equation: ¿¿/¿m ¿ -1/m L, where m L is the liquid mass perturbed by the resonator. The validation of the new concept is presented in this article. An immunosensor application for the detection of a low molecular weight pollutant, the insecticide carbaryl, has been chosen as a validation model. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/28829
url https://riunet.upv.es/handle/10251/28829
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2009-13511 Inmunosensor Piezoelectrico De Alta Frecuencia Para La Deteccion De Bisfenol-A Y Ftalatos En Alimentos Envasados
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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