The effect of the SCD genotype on litter size and weight at weaning

for a variant in the leptin receptor (LEPR) gene. There is a single nucleotide polymorphism (SNP) in the stearoyl- CoA desaturase (SCD) gene that influences the monounsaturated fatty acid content of pork. Here, we investigate single and combined effects of the SCD (rs80912566 T>C) and LEPR (rs709...

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Autores: Solé Mòdol, Emma, Ros Freixedes, Roger, Gol, Sofia, Bosch, Lluís, Tor i Naudí, Marc, Pena i Subirà, Ramona Natacha, Reixach, Josep, Estany Illa, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/72469
Acceso en línea:https://doi.org/10.1016/j.livsci.2021.104763
http://hdl.handle.net/10459.1/72469
Access Level:acceso abierto
Palabra clave:Genetic markers
Litter size
Milk
Pigs
Reproduction
Weaning weight
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network_acronym_str ES
network_name_str España
repository_id_str
spelling The effect of the SCD genotype on litter size and weight at weaningSolé Mòdol, EmmaRos Freixedes, RogerGol, SofiaBosch, LluísTor i Naudí, MarcPena i Subirà, Ramona NatachaReixach, JosepEstany Illa, JoanGenetic markersLitter sizeMilkPigsReproductionWeaning weightfor a variant in the leptin receptor (LEPR) gene. There is a single nucleotide polymorphism (SNP) in the stearoyl- CoA desaturase (SCD) gene that influences the monounsaturated fatty acid content of pork. Here, we investigate single and combined effects of the SCD (rs80912566 T>C) and LEPR (rs709596309 C>T) SNP on litter size and weaning weight. A total of 1,246 sows of known genotype for SCD (732 of which were also genotyped for LEPR) were monitored for age at farrowing, number of piglets born, born alive and weaned, and litter weight at weaning during two years. The effects of these SNP and of a variant in the diacylglycerol O-acyltransferase 2 (DGAT2) gene on milk fat content and fatty acid composition were also analysed in 99 primiparous sows. No adverse effects of the SCD SNP on overall reproductive performance were observed. However, in primiparous sows, we found that the SCD-T allele, the one that increases the monounsaturated fatty acid content, influenced negatively the weight of piglets at weaning (the piglets from SCD-TT sows weighted 126 g less at weaning than those from SCD-CT sows), especially in combination with the LEPR-TT genotype (the piglets from SCD-TT/LEPRTT sows weighted 277 g less at weaning than piglets from SCD-C /LEPR-C sows). In contrast to SCD, the negative effect of the LEPR-TT sows on the piglets weaning weight was maintained in all parities (piglets from LEPR-TT sows were on average 126 g lighter than LEPR-C sows). The unfavourable effect of the SCD-T allele on the litter weight of primiparous sows could be due to lower body reserves at first farrowing (SCD-TT pigs had 0.62 mm less backfat thickness at 205 d than SCD-CT pigs) together with larger litters at birth (the SCD-TT sows had 0.32 more piglets born alive per litter than the SCD-CT sows). The milk of primiparous sows with the SCD-T allele showed higher desaturation indices (i.e. higher monounsaturated to saturated fatty acid ratios), but lower fat content. No relevant effects of the DGAT2 SNP on milk traits were found. In conclusion, the SCD SNP does not impact overall reproductive performance in pigs, but cautious management of SCD-TT gilts is recommended.This research was supported by the Spanish Ministry of Science, Innovation & Universities and the EU Regional Development Funds (grant RTI2018–101,346-B-I00). ES is recipient of a PhD scholarship from the University of Lleida.Elsevier2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1016/j.livsci.2021.104763http://hdl.handle.net/10459.1/72469http://hdl.handle.net/10459.1/72469reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101346-B-I00Reproducció del document publicat a: https://doi.org/10.1016/j.livsci.2021.104763Livestock Science, 2021, vol. 254, article 104763cc-by-nc-nd (c) Solé et al., 2021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/oai:recercat.cat:10459.1/724692026-05-29T05:05:01Z
dc.title.none.fl_str_mv The effect of the SCD genotype on litter size and weight at weaning
title The effect of the SCD genotype on litter size and weight at weaning
spellingShingle The effect of the SCD genotype on litter size and weight at weaning
Solé Mòdol, Emma
Genetic markers
Litter size
Milk
Pigs
Reproduction
Weaning weight
title_short The effect of the SCD genotype on litter size and weight at weaning
title_full The effect of the SCD genotype on litter size and weight at weaning
title_fullStr The effect of the SCD genotype on litter size and weight at weaning
title_full_unstemmed The effect of the SCD genotype on litter size and weight at weaning
title_sort The effect of the SCD genotype on litter size and weight at weaning
dc.creator.none.fl_str_mv Solé Mòdol, Emma
Ros Freixedes, Roger
Gol, Sofia
Bosch, Lluís
Tor i Naudí, Marc
Pena i Subirà, Ramona Natacha
Reixach, Josep
Estany Illa, Joan
author Solé Mòdol, Emma
author_facet Solé Mòdol, Emma
Ros Freixedes, Roger
Gol, Sofia
Bosch, Lluís
Tor i Naudí, Marc
Pena i Subirà, Ramona Natacha
Reixach, Josep
Estany Illa, Joan
author_role author
author2 Ros Freixedes, Roger
Gol, Sofia
Bosch, Lluís
Tor i Naudí, Marc
Pena i Subirà, Ramona Natacha
Reixach, Josep
Estany Illa, Joan
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genetic markers
Litter size
Milk
Pigs
Reproduction
Weaning weight
topic Genetic markers
Litter size
Milk
Pigs
Reproduction
Weaning weight
description for a variant in the leptin receptor (LEPR) gene. There is a single nucleotide polymorphism (SNP) in the stearoyl- CoA desaturase (SCD) gene that influences the monounsaturated fatty acid content of pork. Here, we investigate single and combined effects of the SCD (rs80912566 T>C) and LEPR (rs709596309 C>T) SNP on litter size and weaning weight. A total of 1,246 sows of known genotype for SCD (732 of which were also genotyped for LEPR) were monitored for age at farrowing, number of piglets born, born alive and weaned, and litter weight at weaning during two years. The effects of these SNP and of a variant in the diacylglycerol O-acyltransferase 2 (DGAT2) gene on milk fat content and fatty acid composition were also analysed in 99 primiparous sows. No adverse effects of the SCD SNP on overall reproductive performance were observed. However, in primiparous sows, we found that the SCD-T allele, the one that increases the monounsaturated fatty acid content, influenced negatively the weight of piglets at weaning (the piglets from SCD-TT sows weighted 126 g less at weaning than those from SCD-CT sows), especially in combination with the LEPR-TT genotype (the piglets from SCD-TT/LEPRTT sows weighted 277 g less at weaning than piglets from SCD-C /LEPR-C sows). In contrast to SCD, the negative effect of the LEPR-TT sows on the piglets weaning weight was maintained in all parities (piglets from LEPR-TT sows were on average 126 g lighter than LEPR-C sows). The unfavourable effect of the SCD-T allele on the litter weight of primiparous sows could be due to lower body reserves at first farrowing (SCD-TT pigs had 0.62 mm less backfat thickness at 205 d than SCD-CT pigs) together with larger litters at birth (the SCD-TT sows had 0.32 more piglets born alive per litter than the SCD-CT sows). The milk of primiparous sows with the SCD-T allele showed higher desaturation indices (i.e. higher monounsaturated to saturated fatty acid ratios), but lower fat content. No relevant effects of the DGAT2 SNP on milk traits were found. In conclusion, the SCD SNP does not impact overall reproductive performance in pigs, but cautious management of SCD-TT gilts is recommended.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.livsci.2021.104763
http://hdl.handle.net/10459.1/72469
http://hdl.handle.net/10459.1/72469
url https://doi.org/10.1016/j.livsci.2021.104763
http://hdl.handle.net/10459.1/72469
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-101346-B-I00
Reproducció del document publicat a: https://doi.org/10.1016/j.livsci.2021.104763
Livestock Science, 2021, vol. 254, article 104763
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Solé et al., 2021
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd (c) Solé et al., 2021
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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