Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment

Background: Alzheimer’s disease (AD) is a silent disorder that needs the earliest possible intervention in order to reduce its high economic and social impact. It has been recently suggested that subjective cognitive decline (SCD) appears at preclinical stages many years before the onset of AD. Ther...

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Autores: Fernández Blázquez, Miguel Ángel, Avila Villanueva, Marina, Maestu Unturbe, Fernando, Medina, Miguel
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/132685
Acceso en línea:https://hdl.handle.net/20.500.14352/132685
Access Level:acceso abierto
Palabra clave:Aging
Alzheimer’s disease
Cognitive symptoms
Dementia
Mild cognitive impairment
Subjective cognitive decline
Neuropsicología
Psicología cognitiva
61 Psicología
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spelling Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairmentFernández Blázquez, Miguel ÁngelAvila Villanueva, MarinaMaestu Unturbe, FernandoMedina, MiguelAgingAlzheimer’s diseaseCognitive symptomsDementiaMild cognitive impairmentSubjective cognitive declineNeuropsicologíaPsicología cognitiva61 PsicologíaBackground: Alzheimer’s disease (AD) is a silent disorder that needs the earliest possible intervention in order to reduce its high economic and social impact. It has been recently suggested that subjective cognitive decline (SCD) appears at preclinical stages many years before the onset of AD. Therefore, SCD could become an ideal target for early therapeutic intervention. Objective: The goal of this study was to evaluate the clinical significance of SCD on the conversion from a cognitively healthy stage to a mild cognitive impairment (MCI) in one-year follow-up. Methods: A total of 608 cognitively intact individuals from the Vallecas Project’s cohort, a community-based prospective study to identify early markers of AD, were enrolled in this study. Participants were classified in three groups: i) No Complaints (NCg), ii) Subjects with complaints in one or more cognitive domains (SCDg), and iii) Subjects who, besides complaints, fulfilled the features of SCD Plus proposed by the International Working Group of SCD (SCD-Pg). Results: Individuals were followed up for a mean of 13.1 months (range 10.7–22.4). During this time, 41 volunteers developed MCI (6.7% of total sample). The conversion rate for SCD-Pg (18.9%) was significantly higher than SCDg (5.6%) and NCg (4.9%). Conclusion: Specific features associated with SCD may help to identify individuals at high risk of fast conversion to MCI. These results highlight the importance of a close follow-up of subjects with SCD-P and include them in early intervention programs because of their increased risk for the development of MCI.SageUniversidad Complutense de Madrid20172017-11-0120172017-11-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/132685reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1326852026-06-02T12:44:21Z
dc.title.none.fl_str_mv Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
title Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
spellingShingle Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
Fernández Blázquez, Miguel Ángel
Aging
Alzheimer’s disease
Cognitive symptoms
Dementia
Mild cognitive impairment
Subjective cognitive decline
Neuropsicología
Psicología cognitiva
61 Psicología
title_short Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
title_full Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
title_fullStr Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
title_full_unstemmed Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
title_sort Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment
dc.creator.none.fl_str_mv Fernández Blázquez, Miguel Ángel
Avila Villanueva, Marina
Maestu Unturbe, Fernando
Medina, Miguel
author Fernández Blázquez, Miguel Ángel
author_facet Fernández Blázquez, Miguel Ángel
Avila Villanueva, Marina
Maestu Unturbe, Fernando
Medina, Miguel
author_role author
author2 Avila Villanueva, Marina
Maestu Unturbe, Fernando
Medina, Miguel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Aging
Alzheimer’s disease
Cognitive symptoms
Dementia
Mild cognitive impairment
Subjective cognitive decline
Neuropsicología
Psicología cognitiva
61 Psicología
topic Aging
Alzheimer’s disease
Cognitive symptoms
Dementia
Mild cognitive impairment
Subjective cognitive decline
Neuropsicología
Psicología cognitiva
61 Psicología
description Background: Alzheimer’s disease (AD) is a silent disorder that needs the earliest possible intervention in order to reduce its high economic and social impact. It has been recently suggested that subjective cognitive decline (SCD) appears at preclinical stages many years before the onset of AD. Therefore, SCD could become an ideal target for early therapeutic intervention. Objective: The goal of this study was to evaluate the clinical significance of SCD on the conversion from a cognitively healthy stage to a mild cognitive impairment (MCI) in one-year follow-up. Methods: A total of 608 cognitively intact individuals from the Vallecas Project’s cohort, a community-based prospective study to identify early markers of AD, were enrolled in this study. Participants were classified in three groups: i) No Complaints (NCg), ii) Subjects with complaints in one or more cognitive domains (SCDg), and iii) Subjects who, besides complaints, fulfilled the features of SCD Plus proposed by the International Working Group of SCD (SCD-Pg). Results: Individuals were followed up for a mean of 13.1 months (range 10.7–22.4). During this time, 41 volunteers developed MCI (6.7% of total sample). The conversion rate for SCD-Pg (18.9%) was significantly higher than SCDg (5.6%) and NCg (4.9%). Conclusion: Specific features associated with SCD may help to identify individuals at high risk of fast conversion to MCI. These results highlight the importance of a close follow-up of subjects with SCD-P and include them in early intervention programs because of their increased risk for the development of MCI.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-11-01
2017
2017-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/132685
url https://hdl.handle.net/20.500.14352/132685
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sage
publisher.none.fl_str_mv Sage
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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