Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis

Background: The COVID-19 pandemic could have negative effects on tuberculosis (TB) control. The objective was to assess the impact of the pandemic in contact tracing, TB and latent tuberculosis infection (LTBI) in contacts of patients with pulmonary TB in Catalonia (Spain). Methods: Contact tracing...

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Autores: Godoy i García, Pere, Parrón, Ignacio, Barrabeig i Fabregat, Irene, Caylà, Joan A., Clotet, Laura, Follia, Núria, Carol, Monica, Orcau, Angels, Alsedà Graells, Miquel, Ferrús, Gloria, Plans-Rubio, Pedro, Jané, Mireia, Millet, Joan Pau, Domínguez García, Àngela
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/83629
Acceso en línea:https://doi.org/10.1093/eurpub/ckac031
http://hdl.handle.net/10459.1/83629
Access Level:acceso abierto
Palabra clave:Pulmonary tuberculosis
Infectious disease contact tracing
Spain
Tuberculin test
Latent tuberculosis
Pandemics
Interferon gamma
Release assay
Covid-19
Coronavirus pandemic
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spelling Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosisGodoy i García, PereParrón, IgnacioBarrabeig i Fabregat, IreneCaylà, Joan A.Clotet, LauraFollia, NúriaCarol, MonicaOrcau, AngelsAlsedà Graells, MiquelFerrús, GloriaPlans-Rubio, PedroJané, MireiaMillet, Joan PauDomínguez García, ÀngelaPulmonary tuberculosisInfectious disease contact tracingSpainTuberculin testLatent tuberculosisPandemicsInterferon gammaRelease assayCovid-19Coronavirus pandemicBackground: The COVID-19 pandemic could have negative effects on tuberculosis (TB) control. The objective was to assess the impact of the pandemic in contact tracing, TB and latent tuberculosis infection (LTBI) in contacts of patients with pulmonary TB in Catalonia (Spain). Methods: Contact tracing was carried out in cases of pulmonary TB detected during 14 months in the pre-pandemic period (1 January 2019 to 28 February 2020) and 14 months in the pandemic period (1 March 2020 to 30 April 2021). Contacts received the tuberculin skin test and/or interferon gamma release assay and it was determined whether they had TB or LTBI. Variables associated with TB or LTBI in contacts (study period and sociodemographic variables) were analyzed using adjusted odds ratio (aOR) and the 95% confidence intervals (95% CI). Results: The pre-pandemic and pandemic periods showed, respectively: 503 and 255 pulmonary TB reported cases (reduction of 50.7%); and 4676 and 1687 contacts studied (reduction of 36.1%). In these periods, the proportion of TB cases among the contacts was 1.9% (84/4307) and 2.2% (30/1381) (P = 0.608); and the proportion of LTBI was 25.3% (1090/4307) and 29.2% (403/1381) (P < 0.001). The pandemic period was associated to higher LTBI proportion (aOR = 1.3; 95% CI 1.1–1.5), taking into account the effect on LTBI of the other variables studied as sex, age, household contact and migrant status. Conclusions: COVID-19 is affecting TB control due to less exhaustive TB and LTBI case detection. An increase in LTBI was observed during the pandemic period. Efforts should be made to improve detection of TB and LTBI among contacts of TB cases.This study was supported by the Ministry of Science and Innovation, Institute of Health Carlos III (Project PI18/01751) and Fondo Europeo de Desarrollo Regional (FEDER-Una manera de hacer Europa).Oxford University Press202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1093/eurpub/ckac031http://hdl.handle.net/10459.1/83629http://hdl.handle.net/10459.1/83629reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01751Reproducció del document publicat a: https://doi.org/10.1093/eurpub/ckac031European Journal of Public Health, 2022, ckac031cc-by-nc (c) The Authors, 2022info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/oai:recercat.cat:10459.1/836292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
title Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
spellingShingle Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
Godoy i García, Pere
Pulmonary tuberculosis
Infectious disease contact tracing
Spain
Tuberculin test
Latent tuberculosis
Pandemics
Interferon gamma
Release assay
Covid-19
Coronavirus pandemic
title_short Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
title_full Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
title_fullStr Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
title_full_unstemmed Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
title_sort Impact of the COVID-19 pandemic on contact tracing of patients with pulmonary tuberculosis
dc.creator.none.fl_str_mv Godoy i García, Pere
Parrón, Ignacio
Barrabeig i Fabregat, Irene
Caylà, Joan A.
Clotet, Laura
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Ferrús, Gloria
Plans-Rubio, Pedro
Jané, Mireia
Millet, Joan Pau
Domínguez García, Àngela
author Godoy i García, Pere
author_facet Godoy i García, Pere
Parrón, Ignacio
Barrabeig i Fabregat, Irene
Caylà, Joan A.
Clotet, Laura
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Ferrús, Gloria
Plans-Rubio, Pedro
Jané, Mireia
Millet, Joan Pau
Domínguez García, Àngela
author_role author
author2 Parrón, Ignacio
Barrabeig i Fabregat, Irene
Caylà, Joan A.
Clotet, Laura
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Ferrús, Gloria
Plans-Rubio, Pedro
Jané, Mireia
Millet, Joan Pau
Domínguez García, Àngela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pulmonary tuberculosis
Infectious disease contact tracing
Spain
Tuberculin test
Latent tuberculosis
Pandemics
Interferon gamma
Release assay
Covid-19
Coronavirus pandemic
topic Pulmonary tuberculosis
Infectious disease contact tracing
Spain
Tuberculin test
Latent tuberculosis
Pandemics
Interferon gamma
Release assay
Covid-19
Coronavirus pandemic
description Background: The COVID-19 pandemic could have negative effects on tuberculosis (TB) control. The objective was to assess the impact of the pandemic in contact tracing, TB and latent tuberculosis infection (LTBI) in contacts of patients with pulmonary TB in Catalonia (Spain). Methods: Contact tracing was carried out in cases of pulmonary TB detected during 14 months in the pre-pandemic period (1 January 2019 to 28 February 2020) and 14 months in the pandemic period (1 March 2020 to 30 April 2021). Contacts received the tuberculin skin test and/or interferon gamma release assay and it was determined whether they had TB or LTBI. Variables associated with TB or LTBI in contacts (study period and sociodemographic variables) were analyzed using adjusted odds ratio (aOR) and the 95% confidence intervals (95% CI). Results: The pre-pandemic and pandemic periods showed, respectively: 503 and 255 pulmonary TB reported cases (reduction of 50.7%); and 4676 and 1687 contacts studied (reduction of 36.1%). In these periods, the proportion of TB cases among the contacts was 1.9% (84/4307) and 2.2% (30/1381) (P = 0.608); and the proportion of LTBI was 25.3% (1090/4307) and 29.2% (403/1381) (P < 0.001). The pandemic period was associated to higher LTBI proportion (aOR = 1.3; 95% CI 1.1–1.5), taking into account the effect on LTBI of the other variables studied as sex, age, household contact and migrant status. Conclusions: COVID-19 is affecting TB control due to less exhaustive TB and LTBI case detection. An increase in LTBI was observed during the pandemic period. Efforts should be made to improve detection of TB and LTBI among contacts of TB cases.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1093/eurpub/ckac031
http://hdl.handle.net/10459.1/83629
http://hdl.handle.net/10459.1/83629
url https://doi.org/10.1093/eurpub/ckac031
http://hdl.handle.net/10459.1/83629
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01751
Reproducció del document publicat a: https://doi.org/10.1093/eurpub/ckac031
European Journal of Public Health, 2022, ckac031
dc.rights.none.fl_str_mv cc-by-nc (c) The Authors, 2022
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
rights_invalid_str_mv cc-by-nc (c) The Authors, 2022
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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