Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers

The development of wearable devices for sweat analysis has experienced significant growth in the last two decades, being the main focus the monitoring of athletes health during workouts. One of the main challenges of these approaches has been to attain the continuous monitoring of sweat for time per...

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Autores: Rovira, Meritxell, Lafaye, Céline, Demuru, Silvia, Kunnel, Brince Paul, Aymerich, Joan, Cuenca, Javier, Serra-Graells, Francesc, Margarit-Taulé, Josep Maria, Haque, Rubaiyet, Saubade, Mathieu, Fernández Sánchez, César, Jiménez-Jorquera, Cecilia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/369279
Acceso en línea:http://hdl.handle.net/10261/369279
https://api.elsevier.com/content/abstract/scopus_id/85198584178
Access Level:acceso abierto
Palabra clave:Capillary-based fluidics
Fitness management
Healthcare
Microfabricated sensor
Sweat biomarker
Wearable sensor
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spelling Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkersRovira, MeritxellLafaye, CélineDemuru, SilviaKunnel, Brince PaulAymerich, JoanCuenca, JavierSerra-Graells, FrancescMargarit-Taulé, Josep MariaHaque, RubaiyetSaubade, MathieuFernández Sánchez, CésarJiménez-Jorquera, CeciliaCapillary-based fluidicsFitness managementHealthcareMicrofabricated sensorSweat biomarkerWearable sensorThe development of wearable devices for sweat analysis has experienced significant growth in the last two decades, being the main focus the monitoring of athletes health during workouts. One of the main challenges of these approaches has been to attain the continuous monitoring of sweat for time periods over 1 h. This is the main challenge addressed in this work by designing an analytical platform that combines the high performance of potentiometric sensors and a fluidic structure made of a plastic fabric into a multiplexed wearable device. The platform comprises Ion-Sensitive Field-Effect Transistors (ISFETs) manufactured on silicon, a tailor-made solid-state reference electrode, and a temperature sensor integrated into a patch-like polymeric substrate, together with the component that easily collects and drives samples under continuous capillary flow to the sensor areas. ISFET sensors for measuring pH, sodium, and potassium ions were fully characterized in artificial sweat solutions, providing reproducible and stable responses. Then, the real-time and continuous monitoring of the biomarkers in sweat with the wearable platform was assessed by comparing the ISFETs responses recorded during an 85-min continuous exercise session with the concentration values measured using commercial Ion-Selective Electrodes (ISEs) in samples collected at certain times during the session. The developed sensing platform enables the continuous monitoring of biomarkers and facilitates the study of the effects of various real working conditions, such as cycling power and skin temperature, on the target biomarker concentration levels.This work was performed within the WeCare project, funded by the Swiss National Science Foundation (SNSF, Sinergia Program, Project CRSIIS_177255/1) and used the ICTS Network MICRONANOFABS supported by the Spanish Ministry of Science and Innovation. We would also like to thank Miwon, South Corea and Allnex for providing photocurable polymers. The authors acknowledge the participation in the Electrobionet network (ref. RED2022-134120-T) funded by MICIN/AEI/10.13039/501100011033).With funding from the Spanish government through the ‘María de Maeztu Unit of Excelence accreditation (CEX2023- 001397-M).Peer reviewedElsevierSwiss National Science FoundationMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)0000-0002-0460-15620000-0003-2676-97850000-0001-9258-93660000-0001-5112-51780000-0002-7274-19110000-0003-2779-92810000-0003-2381-0033Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/369279https://api.elsevier.com/content/abstract/scopus_id/85198584178reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MMICIN/AEI/2022-134120-Tinfo:eu-repo/grantAgreement/SNF/CRSIIS_177255/1info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación/CEX2023-001397-MBiosensors & bioelectronicshttps://doi.org/10.1016/j.bios.2024.116560Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3692792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
title Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
spellingShingle Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
Rovira, Meritxell
Capillary-based fluidics
Fitness management
Healthcare
Microfabricated sensor
Sweat biomarker
Wearable sensor
title_short Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
title_full Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
title_fullStr Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
title_full_unstemmed Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
title_sort Assessing the performance of a robust multiparametric wearable patch integrating silicon-based sensors for real-time continuous monitoring of sweat biomarkers
dc.creator.none.fl_str_mv Rovira, Meritxell
Lafaye, Céline
Demuru, Silvia
Kunnel, Brince Paul
Aymerich, Joan
Cuenca, Javier
Serra-Graells, Francesc
Margarit-Taulé, Josep Maria
Haque, Rubaiyet
Saubade, Mathieu
Fernández Sánchez, César
Jiménez-Jorquera, Cecilia
author Rovira, Meritxell
author_facet Rovira, Meritxell
Lafaye, Céline
Demuru, Silvia
Kunnel, Brince Paul
Aymerich, Joan
Cuenca, Javier
Serra-Graells, Francesc
Margarit-Taulé, Josep Maria
Haque, Rubaiyet
Saubade, Mathieu
Fernández Sánchez, César
Jiménez-Jorquera, Cecilia
author_role author
author2 Lafaye, Céline
Demuru, Silvia
Kunnel, Brince Paul
Aymerich, Joan
Cuenca, Javier
Serra-Graells, Francesc
Margarit-Taulé, Josep Maria
Haque, Rubaiyet
Saubade, Mathieu
Fernández Sánchez, César
Jiménez-Jorquera, Cecilia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Swiss National Science Foundation
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
0000-0002-0460-1562
0000-0003-2676-9785
0000-0001-9258-9366
0000-0001-5112-5178
0000-0002-7274-1911
0000-0003-2779-9281
0000-0003-2381-0033
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Capillary-based fluidics
Fitness management
Healthcare
Microfabricated sensor
Sweat biomarker
Wearable sensor
topic Capillary-based fluidics
Fitness management
Healthcare
Microfabricated sensor
Sweat biomarker
Wearable sensor
description The development of wearable devices for sweat analysis has experienced significant growth in the last two decades, being the main focus the monitoring of athletes health during workouts. One of the main challenges of these approaches has been to attain the continuous monitoring of sweat for time periods over 1 h. This is the main challenge addressed in this work by designing an analytical platform that combines the high performance of potentiometric sensors and a fluidic structure made of a plastic fabric into a multiplexed wearable device. The platform comprises Ion-Sensitive Field-Effect Transistors (ISFETs) manufactured on silicon, a tailor-made solid-state reference electrode, and a temperature sensor integrated into a patch-like polymeric substrate, together with the component that easily collects and drives samples under continuous capillary flow to the sensor areas. ISFET sensors for measuring pH, sodium, and potassium ions were fully characterized in artificial sweat solutions, providing reproducible and stable responses. Then, the real-time and continuous monitoring of the biomarkers in sweat with the wearable platform was assessed by comparing the ISFETs responses recorded during an 85-min continuous exercise session with the concentration values measured using commercial Ion-Selective Electrodes (ISEs) in samples collected at certain times during the session. The developed sensing platform enables the continuous monitoring of biomarkers and facilitates the study of the effects of various real working conditions, such as cycling power and skin temperature, on the target biomarker concentration levels.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/369279
https://api.elsevier.com/content/abstract/scopus_id/85198584178
url http://hdl.handle.net/10261/369279
https://api.elsevier.com/content/abstract/scopus_id/85198584178
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MMICIN/AEI/2022-134120-T
info:eu-repo/grantAgreement/SNF/CRSIIS_177255/1
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación/CEX2023-001397-M
Biosensors & bioelectronics
https://doi.org/10.1016/j.bios.2024.116560
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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