Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis

Purpose: The purpose of this study is to assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis (LC) and determine the associated risk factors, evaluating the usefulness of FRAX as a screening method to identify patients at a higher risk of fracture. Methods:...

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Autores: Sánchez Delgado, Jordi|||0000-0002-5217-6492, Profitós Font, Joaquim|||0000-0001-7569-130X, Arévalo Salaet, Marta|||0000-0002-1863-7494, Lira, Alba|||0000-0001-9280-613X, Mármol, Carlos, Miquel Planas, Mireia|||0000-0003-4566-4962, Casas, Meritxell|||0000-0001-7227-7277, Vergara, Mercedes|||0000-0002-6971-8657, Calvet, Xavier|||0000-0002-6278-9663, Berlanga Escalera, Eugenio|||0000-0002-9774-4051, Rio, Luis del, Valero, Oliver|||0000-0003-0014-9916, Costa, Ester, Larrosa, Marta|||0000-0001-9891-4561, Casado, Enrique|||0000-0001-8839-6430
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289022
Acceso en línea:https://ddd.uab.cat/record/289022
https://dx.doi.org/urn:doi:10.3390/jcm13010188
Access Level:acceso abierto
Palabra clave:Bone mineral density
FRAX®
Liver cirrhosis
Osteoporosis
Trabecular bone score
Vertebral fracture
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spelling Osteoporosis and Fragility Fractures in Patients with Liver CirrhosisUsefulness of FRAX® as a Screening ToolSánchez Delgado, Jordi|||0000-0002-5217-6492Profitós Font, Joaquim|||0000-0001-7569-130XArévalo Salaet, Marta|||0000-0002-1863-7494Lira, Alba|||0000-0001-9280-613XMármol, CarlosMiquel Planas, Mireia|||0000-0003-4566-4962Casas, Meritxell|||0000-0001-7227-7277Vergara, Mercedes|||0000-0002-6971-8657Calvet, Xavier|||0000-0002-6278-9663Berlanga Escalera, Eugenio|||0000-0002-9774-4051Rio, Luis delValero, Oliver|||0000-0003-0014-9916Costa, EsterLarrosa, Marta|||0000-0001-9891-4561Casado, Enrique|||0000-0001-8839-6430Bone mineral densityFRAX®Liver cirrhosisOsteoporosisTrabecular bone scoreVertebral fracturePurpose: The purpose of this study is to assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis (LC) and determine the associated risk factors, evaluating the usefulness of FRAX as a screening method to identify patients at a higher risk of fracture. Methods: This was a cross-sectional study. Demographic, clinical, and analytical data were collected in a randomized sample of LC patients attending the Hepatology Department of a university hospital. We assessed the absolute risk of fracture at 10 years (FRAX) and based on the bone mineral density (BMD), the presence of morphometric vertebral fracture with a vertebral fracture assessment (VFA), or a thoracic and lumbar X-ray and bone microarchitecture with a trabecular bone score (TBS). Results: Ninety-two patients were included (71% male); the mean age was 63 ± 11.3 years. The main etiology of LC was alcoholism (52.2%), and most patients were Child-Pugh A (80.4%), with a mean model for end-stage liver disease (MELD) score of 10.1 ± 3.6. Sixteen patients (17.4%) had osteoporosis, and fifty-four (58.7%) had osteopenia. Eight patients (8.7%) had suffered at least one fragility fracture. The absolute risk of a major fracture according to FRAX without the BMD was 5.7 ± 4.5%. Risk factors associated with osteoporosis were age and the female sex. BMI. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/289022https://dx.doi.org/urn:doi:10.3390/jcm13010188reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2890222026-06-06T12:50:31Z
dc.title.none.fl_str_mv Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
Usefulness of FRAX® as a Screening Tool
title Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
spellingShingle Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
Sánchez Delgado, Jordi|||0000-0002-5217-6492
Bone mineral density
FRAX®
Liver cirrhosis
Osteoporosis
Trabecular bone score
Vertebral fracture
title_short Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
title_full Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
title_fullStr Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
title_full_unstemmed Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
title_sort Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis
dc.creator.none.fl_str_mv Sánchez Delgado, Jordi|||0000-0002-5217-6492
Profitós Font, Joaquim|||0000-0001-7569-130X
Arévalo Salaet, Marta|||0000-0002-1863-7494
Lira, Alba|||0000-0001-9280-613X
Mármol, Carlos
Miquel Planas, Mireia|||0000-0003-4566-4962
Casas, Meritxell|||0000-0001-7227-7277
Vergara, Mercedes|||0000-0002-6971-8657
Calvet, Xavier|||0000-0002-6278-9663
Berlanga Escalera, Eugenio|||0000-0002-9774-4051
Rio, Luis del
Valero, Oliver|||0000-0003-0014-9916
Costa, Ester
Larrosa, Marta|||0000-0001-9891-4561
Casado, Enrique|||0000-0001-8839-6430
author Sánchez Delgado, Jordi|||0000-0002-5217-6492
author_facet Sánchez Delgado, Jordi|||0000-0002-5217-6492
Profitós Font, Joaquim|||0000-0001-7569-130X
Arévalo Salaet, Marta|||0000-0002-1863-7494
Lira, Alba|||0000-0001-9280-613X
Mármol, Carlos
Miquel Planas, Mireia|||0000-0003-4566-4962
Casas, Meritxell|||0000-0001-7227-7277
Vergara, Mercedes|||0000-0002-6971-8657
Calvet, Xavier|||0000-0002-6278-9663
Berlanga Escalera, Eugenio|||0000-0002-9774-4051
Rio, Luis del
Valero, Oliver|||0000-0003-0014-9916
Costa, Ester
Larrosa, Marta|||0000-0001-9891-4561
Casado, Enrique|||0000-0001-8839-6430
author_role author
author2 Profitós Font, Joaquim|||0000-0001-7569-130X
Arévalo Salaet, Marta|||0000-0002-1863-7494
Lira, Alba|||0000-0001-9280-613X
Mármol, Carlos
Miquel Planas, Mireia|||0000-0003-4566-4962
Casas, Meritxell|||0000-0001-7227-7277
Vergara, Mercedes|||0000-0002-6971-8657
Calvet, Xavier|||0000-0002-6278-9663
Berlanga Escalera, Eugenio|||0000-0002-9774-4051
Rio, Luis del
Valero, Oliver|||0000-0003-0014-9916
Costa, Ester
Larrosa, Marta|||0000-0001-9891-4561
Casado, Enrique|||0000-0001-8839-6430
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bone mineral density
FRAX®
Liver cirrhosis
Osteoporosis
Trabecular bone score
Vertebral fracture
topic Bone mineral density
FRAX®
Liver cirrhosis
Osteoporosis
Trabecular bone score
Vertebral fracture
description Purpose: The purpose of this study is to assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis (LC) and determine the associated risk factors, evaluating the usefulness of FRAX as a screening method to identify patients at a higher risk of fracture. Methods: This was a cross-sectional study. Demographic, clinical, and analytical data were collected in a randomized sample of LC patients attending the Hepatology Department of a university hospital. We assessed the absolute risk of fracture at 10 years (FRAX) and based on the bone mineral density (BMD), the presence of morphometric vertebral fracture with a vertebral fracture assessment (VFA), or a thoracic and lumbar X-ray and bone microarchitecture with a trabecular bone score (TBS). Results: Ninety-two patients were included (71% male); the mean age was 63 ± 11.3 years. The main etiology of LC was alcoholism (52.2%), and most patients were Child-Pugh A (80.4%), with a mean model for end-stage liver disease (MELD) score of 10.1 ± 3.6. Sixteen patients (17.4%) had osteoporosis, and fifty-four (58.7%) had osteopenia. Eight patients (8.7%) had suffered at least one fragility fracture. The absolute risk of a major fracture according to FRAX without the BMD was 5.7 ± 4.5%. Risk factors associated with osteoporosis were age and the female sex. BMI.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/289022
https://dx.doi.org/urn:doi:10.3390/jcm13010188
url https://ddd.uab.cat/record/289022
https://dx.doi.org/urn:doi:10.3390/jcm13010188
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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