Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis

Purpose: The purpose of this study is to assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis (LC) and determine the associated risk factors, evaluating the usefulness of FRAX as a screening method to identify patients at a higher risk of fracture. Methods:...

Descripción completa

Detalles Bibliográficos
Autores: Sánchez Delgado, Jordi|||0000-0002-5217-6492, Profitós Font, Joaquim|||0000-0001-7569-130X, Arévalo Salaet, Marta|||0000-0002-1863-7494, Lira, Alba|||0000-0001-9280-613X, Mármol, Carlos, Miquel Planas, Mireia|||0000-0003-4566-4962, Casas, Meritxell|||0000-0001-7227-7277, Vergara, Mercedes|||0000-0002-6971-8657, Calvet, Xavier|||0000-0002-6278-9663, Berlanga Escalera, Eugenio|||0000-0002-9774-4051, Rio, Luis del, Valero, Oliver|||0000-0003-0014-9916, Costa, Ester, Larrosa, Marta|||0000-0001-9891-4561, Casado, Enrique|||0000-0001-8839-6430
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289022
Acceso en línea:https://ddd.uab.cat/record/289022
https://dx.doi.org/urn:doi:10.3390/jcm13010188
Access Level:acceso abierto
Palabra clave:Bone mineral density
FRAX®
Liver cirrhosis
Osteoporosis
Trabecular bone score
Vertebral fracture
Descripción
Sumario:Purpose: The purpose of this study is to assess the prevalence of osteoporosis and fragility fractures in patients with liver cirrhosis (LC) and determine the associated risk factors, evaluating the usefulness of FRAX as a screening method to identify patients at a higher risk of fracture. Methods: This was a cross-sectional study. Demographic, clinical, and analytical data were collected in a randomized sample of LC patients attending the Hepatology Department of a university hospital. We assessed the absolute risk of fracture at 10 years (FRAX) and based on the bone mineral density (BMD), the presence of morphometric vertebral fracture with a vertebral fracture assessment (VFA), or a thoracic and lumbar X-ray and bone microarchitecture with a trabecular bone score (TBS). Results: Ninety-two patients were included (71% male); the mean age was 63 ± 11.3 years. The main etiology of LC was alcoholism (52.2%), and most patients were Child-Pugh A (80.4%), with a mean model for end-stage liver disease (MELD) score of 10.1 ± 3.6. Sixteen patients (17.4%) had osteoporosis, and fifty-four (58.7%) had osteopenia. Eight patients (8.7%) had suffered at least one fragility fracture. The absolute risk of a major fracture according to FRAX without the BMD was 5.7 ± 4.5%. Risk factors associated with osteoporosis were age and the female sex. BMI.

Similares en LA Referencia