Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients

Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emerg...

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Detalles Bibliográficos
Autores: Andreu-Ballester, Juan Carlos, Arribas, Miguel, Rico, Moises, García-Ballesteros, Carlos, Galindo-Regal, Lorena, Sorando-Serra, Rosa, Albert, Laura, Navarro, Amparo, López-Chuliá, Francesca, Peydró, Federico, Cuéllar Del Hoyo, María Del Carmen
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/101872
Acceso en línea:https://hdl.handle.net/20.500.14352/101872
Access Level:acceso abierto
Palabra clave:579.6
615.28
576.8
Sepsis
αβ T cells
γδ T cell
Apoptosis
Mortality
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
2412 Inmunología
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network_name_str España
repository_id_str
spelling Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patientsAndreu-Ballester, Juan CarlosArribas, MiguelRico, MoisesGarcía-Ballesteros, CarlosGalindo-Regal, LorenaSorando-Serra, RosaAlbert, LauraNavarro, AmparoLópez-Chuliá, FrancescaPeydró, FedericoCuéllar Del Hoyo, María Del Carmen579.6615.28576.8Sepsisαβ T cellsγδ T cellApoptosisMortalityCiencias BiomédicasMicrobiología (Farmacia)Parasitología (Farmacia)2412 InmunologíaImmunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emergency and Intensive Care Departments of two Hospitals, according to the latest criteria for the definition and management of sepsis. According to the severity of the septic process, there was a progressive decrease in T cells, being much more intense in γδ T cells. This decrease recovered in surviving patients, but CD3+CD56+ γδ T cells continued to decreased during hospital stay in non-surviving patients. Apoptosis increased in sepsis. Cell death of CD3+CD56+ γδ T cells progressively increased according to the severity of sepsis, especially in non-surviving patients.ElsevierUniversidad Complutense de Madrid20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/101872reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1018722026-06-02T12:44:21Z
dc.title.none.fl_str_mv Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
title Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
spellingShingle Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
Andreu-Ballester, Juan Carlos
579.6
615.28
576.8
Sepsis
αβ T cells
γδ T cell
Apoptosis
Mortality
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
2412 Inmunología
title_short Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
title_full Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
title_fullStr Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
title_full_unstemmed Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
title_sort Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
dc.creator.none.fl_str_mv Andreu-Ballester, Juan Carlos
Arribas, Miguel
Rico, Moises
García-Ballesteros, Carlos
Galindo-Regal, Lorena
Sorando-Serra, Rosa
Albert, Laura
Navarro, Amparo
López-Chuliá, Francesca
Peydró, Federico
Cuéllar Del Hoyo, María Del Carmen
author Andreu-Ballester, Juan Carlos
author_facet Andreu-Ballester, Juan Carlos
Arribas, Miguel
Rico, Moises
García-Ballesteros, Carlos
Galindo-Regal, Lorena
Sorando-Serra, Rosa
Albert, Laura
Navarro, Amparo
López-Chuliá, Francesca
Peydró, Federico
Cuéllar Del Hoyo, María Del Carmen
author_role author
author2 Arribas, Miguel
Rico, Moises
García-Ballesteros, Carlos
Galindo-Regal, Lorena
Sorando-Serra, Rosa
Albert, Laura
Navarro, Amparo
López-Chuliá, Francesca
Peydró, Federico
Cuéllar Del Hoyo, María Del Carmen
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.6
615.28
576.8
Sepsis
αβ T cells
γδ T cell
Apoptosis
Mortality
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
2412 Inmunología
topic 579.6
615.28
576.8
Sepsis
αβ T cells
γδ T cell
Apoptosis
Mortality
Ciencias Biomédicas
Microbiología (Farmacia)
Parasitología (Farmacia)
2412 Inmunología
description Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emergency and Intensive Care Departments of two Hospitals, according to the latest criteria for the definition and management of sepsis. According to the severity of the septic process, there was a progressive decrease in T cells, being much more intense in γδ T cells. This decrease recovered in surviving patients, but CD3+CD56+ γδ T cells continued to decreased during hospital stay in non-surviving patients. Apoptosis increased in sepsis. Cell death of CD3+CD56+ γδ T cells progressively increased according to the severity of sepsis, especially in non-surviving patients.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/101872
url https://hdl.handle.net/20.500.14352/101872
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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