Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history

INTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the n...

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Autores: Brunet Mas, Eduard, Selva, Anna, Bas-Cutrina, Francesc, Brujats, Anna, Caballol, Berta, Font, Rebeca, Gómez, Bàrbara, Gonzalez Muñosa, Carlos, Busquets, David, Monfort, David, Vera, Diana Patrícia, Maristany, Elisabet, Cirera, Gemma, Torres, Gisela, Castro Poceiro, Jesús, López, Joel, Gonzalez Gonzalez, Laura, Màrquez Mosquera, Lucia, Gallach, Marta, Esteve, Maria, Tremosa, Gemma, Torra, Sandra, Robles Alonso, Virginia, García Iglesias, Pilar, Rodríguez Lago, Iago, Calvet, Xavier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/221342
Acesso em linha:https://hdl.handle.net/2445/221342
Access Level:acceso abierto
Palavra-chave:Malalties inflamatòries intestinals
Malaltia de Crohn
Colitis ulcerosa
Inflammatory bowel diseases
Crohn's disease
Ulcerative colitis
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spelling Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural historyBrunet Mas, EduardSelva, AnnaBas-Cutrina, FrancescBrujats, AnnaCaballol, BertaFont, RebecaGómez, BàrbaraGonzalez Muñosa, CarlosBusquets, DavidMonfort, DavidVera, Diana PatríciaMaristany, ElisabetCirera, GemmaTorres, GiselaCastro Poceiro, JesúsLópez, JoelGonzalez Gonzalez, LauraMàrquez Mosquera, LuciaGallach, MartaEsteve, MariaTremosa, GemmaTorra, SandraRobles Alonso, VirginiaGarcía Iglesias, PilarRodríguez Lago, IagoCalvet, XavierMalalties inflamatòries intestinalsMalaltia de CrohnColitis ulcerosaInflammatory bowel diseasesCrohn's diseaseUlcerative colitisINTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS:An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS:One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 +/- 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. DISCUSSION:Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.Wolters Kluwer Health2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/221342Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000740Clinical and Translational Gastroenterology, 2024, vol. 16, num. 2https://doi.org/10.14309/ctg.0000000000000740cc-by-nc-nd (c) Brunet Mas et al., 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2213422026-05-27T06:46:51Z
dc.title.none.fl_str_mv Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
title Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
spellingShingle Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
Brunet Mas, Eduard
Malalties inflamatòries intestinals
Malaltia de Crohn
Colitis ulcerosa
Inflammatory bowel diseases
Crohn's disease
Ulcerative colitis
title_short Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
title_full Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
title_fullStr Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
title_full_unstemmed Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
title_sort Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history
dc.creator.none.fl_str_mv Brunet Mas, Eduard
Selva, Anna
Bas-Cutrina, Francesc
Brujats, Anna
Caballol, Berta
Font, Rebeca
Gómez, Bàrbara
Gonzalez Muñosa, Carlos
Busquets, David
Monfort, David
Vera, Diana Patrícia
Maristany, Elisabet
Cirera, Gemma
Torres, Gisela
Castro Poceiro, Jesús
López, Joel
Gonzalez Gonzalez, Laura
Màrquez Mosquera, Lucia
Gallach, Marta
Esteve, Maria
Tremosa, Gemma
Torra, Sandra
Robles Alonso, Virginia
García Iglesias, Pilar
Rodríguez Lago, Iago
Calvet, Xavier
author Brunet Mas, Eduard
author_facet Brunet Mas, Eduard
Selva, Anna
Bas-Cutrina, Francesc
Brujats, Anna
Caballol, Berta
Font, Rebeca
Gómez, Bàrbara
Gonzalez Muñosa, Carlos
Busquets, David
Monfort, David
Vera, Diana Patrícia
Maristany, Elisabet
Cirera, Gemma
Torres, Gisela
Castro Poceiro, Jesús
López, Joel
Gonzalez Gonzalez, Laura
Màrquez Mosquera, Lucia
Gallach, Marta
Esteve, Maria
Tremosa, Gemma
Torra, Sandra
Robles Alonso, Virginia
García Iglesias, Pilar
Rodríguez Lago, Iago
Calvet, Xavier
author_role author
author2 Selva, Anna
Bas-Cutrina, Francesc
Brujats, Anna
Caballol, Berta
Font, Rebeca
Gómez, Bàrbara
Gonzalez Muñosa, Carlos
Busquets, David
Monfort, David
Vera, Diana Patrícia
Maristany, Elisabet
Cirera, Gemma
Torres, Gisela
Castro Poceiro, Jesús
López, Joel
Gonzalez Gonzalez, Laura
Màrquez Mosquera, Lucia
Gallach, Marta
Esteve, Maria
Tremosa, Gemma
Torra, Sandra
Robles Alonso, Virginia
García Iglesias, Pilar
Rodríguez Lago, Iago
Calvet, Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties inflamatòries intestinals
Malaltia de Crohn
Colitis ulcerosa
Inflammatory bowel diseases
Crohn's disease
Ulcerative colitis
topic Malalties inflamatòries intestinals
Malaltia de Crohn
Colitis ulcerosa
Inflammatory bowel diseases
Crohn's disease
Ulcerative colitis
description INTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS:An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS:One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 +/- 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. DISCUSSION:Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221342
url https://hdl.handle.net/2445/221342
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000740
Clinical and Translational Gastroenterology, 2024, vol. 16, num. 2
https://doi.org/10.14309/ctg.0000000000000740
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Brunet Mas et al., 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Brunet Mas et al., 2024
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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