Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in catalonia: characteristics and natural history

INTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the n...

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Detalles Bibliográficos
Autores: Brunet Mas, Eduard, Selva, Anna, Bas-Cutrina, Francesc, Brujats, Anna, Caballol, Berta, Font, Rebeca, Gómez, Bàrbara, Gonzalez Muñosa, Carlos, Busquets, David, Monfort, David, Vera, Diana Patrícia, Maristany, Elisabet, Cirera, Gemma, Torres, Gisela, Castro Poceiro, Jesús, López, Joel, Gonzalez Gonzalez, Laura, Màrquez Mosquera, Lucia, Gallach, Marta, Esteve, Maria, Tremosa, Gemma, Torra, Sandra, Robles Alonso, Virginia, García Iglesias, Pilar, Rodríguez Lago, Iago, Calvet, Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221342
Acceso en línea:https://hdl.handle.net/2445/221342
Access Level:acceso abierto
Palabra clave:Malalties inflamatòries intestinals
Malaltia de Crohn
Colitis ulcerosa
Inflammatory bowel diseases
Crohn's disease
Ulcerative colitis
Descripción
Sumario:INTRODUCTION:Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS:An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn's disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS:One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 +/- 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. DISCUSSION:Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.

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