Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis

Interstitial lung disease (ILD) increases morbidity and mortality in patients with rheumatoid arthritis (RA). Although the pathogenesis of ILD associated with RA (RA-ILD+) remains poorly defined, vascular tissue is crucial in lung physiology. In this context, endothelial progenitor cells (EPC) are i...

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Autores: Verónica Pulito-Cueto, Sara Remuzgo-Martínez, Fernanda Genre, Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462, Iturbe Fernández, David|||0000-0002-5241-266X, Sonia Fernández-Rozas, Belén Atienza-Mateo, Leticia Lera-Gómez, Pilar Alonso-Lecue, Javier Rodríguez-Carrio, Diana Prieto-Peña, Virginia Portilla, Blanco Alonso, Ricardo|||0000-0003-2344-2285, Alfonso Corrales, Oreste Gualillo, Cifrián Martínez, José Manuel, López Mejías, Raquel, González-Gay Mantecón, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/21165
Acceso en línea:http://hdl.handle.net/10902/21165
Access Level:acceso abierto
Palabra clave:Endothelial progenitor cells
Vascular damage biomarker
Interstitial lung disease
Rheumatoid arthritis
Idiopathic pulmonary fibrosis
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spelling Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid ArthritisVerónica Pulito-CuetoSara Remuzgo-MartínezFernanda GenreMora Cuesta, Víctor Manuel|||0000-0002-8161-0462Iturbe Fernández, David|||0000-0002-5241-266XSonia Fernández-RozasBelén Atienza-MateoLeticia Lera-GómezPilar Alonso-LecueJavier Rodríguez-CarrioDiana Prieto-PeñaVirginia PortillaBlanco Alonso, Ricardo|||0000-0003-2344-2285Alfonso CorralesOreste GualilloCifrián Martínez, José ManuelLópez Mejías, RaquelGonzález-Gay Mantecón, Miguel ÁngelEndothelial progenitor cellsVascular damage biomarkerInterstitial lung diseaseRheumatoid arthritisIdiopathic pulmonary fibrosisInterstitial lung disease (ILD) increases morbidity and mortality in patients with rheumatoid arthritis (RA). Although the pathogenesis of ILD associated with RA (RA-ILD+) remains poorly defined, vascular tissue is crucial in lung physiology. In this context, endothelial progenitor cells (EPC) are involved in endothelial tissue repair. However, little is known about their implication in RA-ILD+. Accordingly, we aimed to investigate the potential role of EPC related to endothelial damage in RA-ILD+. EPC quantification in peripheral blood from 80 individuals (20 RA-ILD+ patients, 25 RA-ILD? patients, 21 idiopathic pulmonary fibrosis (IPF) patients, and 14 healthy controls) was performed by flow cytometry. EPC were considered as CD34+, CD45low, CD309+ and CD133+. A significant increase in EPC frequency in RA-ILD+ patients, as well as in RA-ILD? and IPF patients, was found when compared with controls (p < 0.001, p = 0.02 and p < 0.001, respectively). RA-ILD+ patients exhibited a higher EPC frequency than the RA-ILD? ones (p = 0.003), but lower than IPF patients (p < 0.001). Our results suggest that EPC increase may represent a reparative compensatory mechanism in patients with RA-ILD+. The degree of EPC frequency may help to identify the presence of ILD in RA patients and to discriminate RA-ILD+ from IPFThis work was partially supported by the European Regional Development Fund (ERDF) and ‘Fondo de Investigación Sanitaria’ [PI18/00043] from Instituto de Salud Carlos III (ISCIII), Health Ministry, Spain. VP-C is supported by a pre-doctoral grant from IDIVAL [PREVAL 18/01]. SR-M is supported by funds of RETICS Program [RD16/0012/0009, ISCIII, co-funded by ERDF]. BA-M is a recipient of a ‘López Albo’ Post-Residency Programme funded by Servicio Cántabro de Salud. LL-G is supported by funds of ISCIII, co-funded by ERDF [PI18/00042]. OG is beneficiary of a grant funded by Xunta de Galicia, Consellería de Educación, Universidade Formación Profesional and Consellería de Economía, Emprego e Industria (GAIN), GPC IN607B2019/10. RL-M is a recipient of a Miguel Servet type I fellowship [ISCIII, co-funded by European Social Fund—ESF, CP16/00033].MDPIUniversidad de Cantabria20202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/21165Journal of clinical medicine 2020, 9, 4098reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/211652026-06-02T12:39:31Z
dc.title.none.fl_str_mv Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
title Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
spellingShingle Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
Verónica Pulito-Cueto
Endothelial progenitor cells
Vascular damage biomarker
Interstitial lung disease
Rheumatoid arthritis
Idiopathic pulmonary fibrosis
title_short Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
title_full Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
title_fullStr Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
title_full_unstemmed Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
title_sort Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis
dc.creator.none.fl_str_mv Verónica Pulito-Cueto
Sara Remuzgo-Martínez
Fernanda Genre
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Iturbe Fernández, David|||0000-0002-5241-266X
Sonia Fernández-Rozas
Belén Atienza-Mateo
Leticia Lera-Gómez
Pilar Alonso-Lecue
Javier Rodríguez-Carrio
Diana Prieto-Peña
Virginia Portilla
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Alfonso Corrales
Oreste Gualillo
Cifrián Martínez, José Manuel
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel
author Verónica Pulito-Cueto
author_facet Verónica Pulito-Cueto
Sara Remuzgo-Martínez
Fernanda Genre
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Iturbe Fernández, David|||0000-0002-5241-266X
Sonia Fernández-Rozas
Belén Atienza-Mateo
Leticia Lera-Gómez
Pilar Alonso-Lecue
Javier Rodríguez-Carrio
Diana Prieto-Peña
Virginia Portilla
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Alfonso Corrales
Oreste Gualillo
Cifrián Martínez, José Manuel
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel
author_role author
author2 Sara Remuzgo-Martínez
Fernanda Genre
Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462
Iturbe Fernández, David|||0000-0002-5241-266X
Sonia Fernández-Rozas
Belén Atienza-Mateo
Leticia Lera-Gómez
Pilar Alonso-Lecue
Javier Rodríguez-Carrio
Diana Prieto-Peña
Virginia Portilla
Blanco Alonso, Ricardo|||0000-0003-2344-2285
Alfonso Corrales
Oreste Gualillo
Cifrián Martínez, José Manuel
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Endothelial progenitor cells
Vascular damage biomarker
Interstitial lung disease
Rheumatoid arthritis
Idiopathic pulmonary fibrosis
topic Endothelial progenitor cells
Vascular damage biomarker
Interstitial lung disease
Rheumatoid arthritis
Idiopathic pulmonary fibrosis
description Interstitial lung disease (ILD) increases morbidity and mortality in patients with rheumatoid arthritis (RA). Although the pathogenesis of ILD associated with RA (RA-ILD+) remains poorly defined, vascular tissue is crucial in lung physiology. In this context, endothelial progenitor cells (EPC) are involved in endothelial tissue repair. However, little is known about their implication in RA-ILD+. Accordingly, we aimed to investigate the potential role of EPC related to endothelial damage in RA-ILD+. EPC quantification in peripheral blood from 80 individuals (20 RA-ILD+ patients, 25 RA-ILD? patients, 21 idiopathic pulmonary fibrosis (IPF) patients, and 14 healthy controls) was performed by flow cytometry. EPC were considered as CD34+, CD45low, CD309+ and CD133+. A significant increase in EPC frequency in RA-ILD+ patients, as well as in RA-ILD? and IPF patients, was found when compared with controls (p < 0.001, p = 0.02 and p < 0.001, respectively). RA-ILD+ patients exhibited a higher EPC frequency than the RA-ILD? ones (p = 0.003), but lower than IPF patients (p < 0.001). Our results suggest that EPC increase may represent a reparative compensatory mechanism in patients with RA-ILD+. The degree of EPC frequency may help to identify the presence of ILD in RA patients and to discriminate RA-ILD+ from IPF
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/21165
url http://hdl.handle.net/10902/21165
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Journal of clinical medicine 2020, 9, 4098
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409751769546752
score 15,300719

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