Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesi...

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Detalles Bibliográficos
Autores: Pulito-Cueto, Verónica, Remuzgo Martínez, Sara, Genre, Fernanda, Atienza Mateo, Belén, Mora Cuesta, Víctor Manuel|||0000-0002-8161-0462, Iturbe Fernández, David|||0000-0002-5241-266X, Lera-Gómez, Leticia, Sebastián Mora-Gil, María, Prieto Peña, Diana, Portilla, Virginia, Blanco Alonso, Ricardo|||0000-0003-2344-2285, Corrales, Alfonso, Ocejo-Vinyals, Javier Gonzalo, Gualillo, Oreste, Ferraz-Amaro, Iván, Cifrián Martínez, José Manuel, López-Mejías, Raquel, González-Gay Mantecón, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/27287
Acceso en línea:https://hdl.handle.net/10902/27287
Access Level:acceso abierto
Palabra clave:VCAM-1
MCP-1
ADMA
Interstitial lung disease
Rheumatoid arthritis
Biomarkers
Pulmonary fibrosis
Descripción
Sumario:Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD+. Methods: We included 21 RA-ILD+ patients and two comparative groups: 25 RA-ILD- patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR. Results: VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD+ patients in relation to RA-ILD- and IPF patients. Additionally, RA-ILD+ patients exhibited increased CCL2 (gene encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD- patients. A lower expression of VCAM1, CCL2, and PRMT1 was observed in RA-ILD+ patients when compared with those with IPF. Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD+ patients. Conclusion: Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD+ from IPF, contributing to the early diagnosis of RA-ILD+.

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