Peroxygenase-Promoted Enzymatic Cascades for the Valorisation of Fatty Acids
Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation. In this contribution we demonstrate the synthetic potenti...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/359664 |
| Acceso en línea: | http://hdl.handle.net/10261/359664 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152945759&doi=10.1002%2fcctc.202300411&partnerID=40&md5=3025b8a6b0f20d4c33d5a8fe5832a673 |
| Access Level: | acceso abierto |
| Palabra clave: | fatty acid valorisation multi-enzyme cascades peroxygenase selective oxyfunctionalisation |
| Sumario: | Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation. In this contribution we demonstrate the synthetic potential of a peroxygenase mutant AaeUPO−Fett for selective fatty acid oxyfunctionalisation. The ω-1 hydroxy fatty acid (esters) produced are further transformed into lactones, alcohols, esters and amines via multi-enzyme cascades thereby paving the way for new fatty acid valorisation pathways. © 2023 The Authors. ChemCatChem published by Wiley-VCH GmbH. |
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