IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy

This article belongs to the Section Molecular Medicine.

Detalles Bibliográficos
Autores: Resino, Salvador, Navarrete-Muñoz, María A., Blanco, Julià, Pacheco, Yolanda M., Castro, Iván, Berenguer, Juan, Santos, Jesús, Vera-Méndez, Francisco Jesús, Górgolas-Hernández-Mora, Miguel, Jiménez-Sousa, María A., Benito, José Miguel, Rallón, Norma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/212405
Acceso en línea:http://hdl.handle.net/10261/212405
Access Level:acceso abierto
Palabra clave:HIV
IL7RA
SNPs
Immune reconstitution
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spelling IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapyResino, SalvadorNavarrete-Muñoz, María A.Blanco, JuliàPacheco, Yolanda M.Castro, IvánBerenguer, JuanSantos, JesúsVera-Méndez, Francisco JesúsGórgolas-Hernández-Mora, MiguelJiménez-Sousa, María A.Benito, José MiguelRallón, NormaHIVIL7RASNPsImmune reconstitutionThis article belongs to the Section Molecular Medicine.Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4+ recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4+ T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4+ T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4+ T-cells count <200 cells/mm3. We performed a retrospective study in 411 patients followed for 24 months with a DNA sample available for genotyping. The change in CD4+ T-cells count during the follow-up was considered as the primary outcome. The rs6897932 polymorphism had a minimum allele frequency (MAF) >20% and was in Hardy–Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4+ T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4+ T-cells increase (AMR = 1.19; p = 0.004), and higher CD4+ T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4+ T-cells at the end of follow-up ≥500 CD4+ cells/mm3 (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini–Hochberg), only the increase of ≥ 400 CD4+ cells/mm3 lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4+ T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4+ T-cells count <200 cells/mm3.This study has been (partially) funded by grants RD12/0017/0031 and D16/0025/0013 to JMB, and RD12/0017/0024 and RD16CIII/0002/0002 to SR as part of the Health Research and Development Strategy, State Plan for Scientific and Technical Research and Innovation (2008–2011; 2013–2016) and co-financed by Institute of Health Carlos III, ISCIII—Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). MA Jiménez-Sousa is funded by project RD16CIII/0002/0002; MA Navarrete-Muñoz is co-funded by RD16/0025/0013 project and Intramural Research Scholarship from IIS-FJD. N Rallón is a Miguel Servet investigator from the ISCIII [grant number CP14/00198].Peer reviewedMultidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIEuropean CommissionResino, Salvador [0000-0001-8783-0450]Castro, Iván [0000-0001-9938-2122]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/212405reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/biom9060233Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2124052026-05-22T06:33:51Z
dc.title.none.fl_str_mv IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
title IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
spellingShingle IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
Resino, Salvador
HIV
IL7RA
SNPs
Immune reconstitution
title_short IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
title_full IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
title_fullStr IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
title_full_unstemmed IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
title_sort IL7RA rs6897932 polymorphism is associated with better CD4+ T-cell recovery in HIV infected patients starting combination antiretroviral therapy
dc.creator.none.fl_str_mv Resino, Salvador
Navarrete-Muñoz, María A.
Blanco, Julià
Pacheco, Yolanda M.
Castro, Iván
Berenguer, Juan
Santos, Jesús
Vera-Méndez, Francisco Jesús
Górgolas-Hernández-Mora, Miguel
Jiménez-Sousa, María A.
Benito, José Miguel
Rallón, Norma
author Resino, Salvador
author_facet Resino, Salvador
Navarrete-Muñoz, María A.
Blanco, Julià
Pacheco, Yolanda M.
Castro, Iván
Berenguer, Juan
Santos, Jesús
Vera-Méndez, Francisco Jesús
Górgolas-Hernández-Mora, Miguel
Jiménez-Sousa, María A.
Benito, José Miguel
Rallón, Norma
author_role author
author2 Navarrete-Muñoz, María A.
Blanco, Julià
Pacheco, Yolanda M.
Castro, Iván
Berenguer, Juan
Santos, Jesús
Vera-Méndez, Francisco Jesús
Górgolas-Hernández-Mora, Miguel
Jiménez-Sousa, María A.
Benito, José Miguel
Rallón, Norma
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Resino, Salvador [0000-0001-8783-0450]
Castro, Iván [0000-0001-9938-2122]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HIV
IL7RA
SNPs
Immune reconstitution
topic HIV
IL7RA
SNPs
Immune reconstitution
description This article belongs to the Section Molecular Medicine.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/212405
url http://hdl.handle.net/10261/212405
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/biom9060233
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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