IL7RA rs6897932 Polymorphism Is Associated with Better CD4(+) T-Cell Recovery in HIV Infected Patients Starting Combination Antiretroviral Therapy

Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4(+) recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4(+) T-cells count. We aimed to analyze the association between IL7R...

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Autores: Resino, Salvador, Navarrete-Munoz, Maria A., Blanco, Julia, Pacheco, Yolanda M., Castro, Ivan, Berenguer, Juan, Santos, Jesus, Vera-Mendez, Francisco J., Gorgolas, Miguel, Jimenez-Sousa, M. Angeles, Benito, Jose M., Rallon, Norma, Moreno, Santiago, Jarrin, Inma, Dalmau, David, Navarro, Maria Luisa, Gonzalez, Maria Isabel, Blanco, Jose Luis, Garcia, Federico, Rubio, Rafael, Iribarren, Jose Antonio, Gutierrez, Felix, Vidal, Francesc, Gonzalez, Juan, Alejos, Belen, Hernando, Victoria, Moreno-Mulet, Cristina, Iniesta, Carlos, Garcia Sousa, Luis Miguel, Sanz Perez, Nieves, Munoz-Fernandez, M. Angeles, Garcia-Merino, Isabel Maria, Consuegra Fernandez, Irene, Gomez Rico, Coral, Gallego de la Fuente, Jorge, Palau Concejo, Paula, Portilla, Joaquin, Merino, Esperanza, Reus, Sergio, Boix, Vicente, Giner, Livia, Gadea, Carmen, Portilla, Irene, Pampliega, Maria, Diez, Marcos, Rodriguez, Juan Carlos, Sanchez-Paya, Jose, Gomez, Juan Luis, Hernandez, Jehovana, Aleman, Maria Remedios, Alonso, Maria del Mar, Hernandez, Maria Inmaculada, Diaz-Flores, Felicitas, Garcia, Dacil, Pelazas, Ricardo, Lopez Lirola, Ana, Sanz Moreno, Jose, Arranz Caso, Alberto, Hernandez Gutierrez, Cristina, Novella Mena, Maria, Pulido, Federico, Bisbal, Otilia, Hernando, Asuncion, Dominguez, Lourdes, Crestelo, David Rial, Bermejo, Laura, Santacreu, Mireia, Arrizabalaga, Julio, Aramburu, Maria Jose, Camino, Xabier, Rodriguez-Arrondo, Francisco, von Wichmann, Miguel Angel, Pascual Tome, Lidia, Goenaga, Miguel Angel, Bustinduy, Ma Jesus, Azkune, Harkaitz, Ibarguren, Maialen, Lizardi, Aitziber, Kortajarena, Xabier, Masia, Mar, Padilla, Sergio, Navarro, Andres, Montolio, Fernando, Robledano, Catalina, Gregori Colome, Joan, Adsuar, Araceli, Pascual, Rafael, Fernandez, Marta, Garcia, Elena, Garcia, Jose Alberto, Barber, Xavier, Lopez Bernaldo de Quiros, Juan Carlos, Gutierrez, Isabel, Ramirez, Margarita, Padilla, Belen, Gijon, Paloma, Aldamiz-Echevarria, Teresa, Tejerina, Francisco, Parras, Francisco Jose, Balsalobre, Pascual, Diez, Cristina, Perez Latorre, Leire, Peraire, Joaquin, Vilades, Consuelo, Veloso, Sergio, Vargas, Montserrat, Lopez-Dupla, Miguel, Olona, Montserrat, Rull, Anna, Rodriguez-Gallego, Esther, Alba, Veronica, Montero Alonso, Marta, Lopez Aldeguer, Jose, Blanes Julia, Marino, Tasias Pitarch, Maria, Castro Hernandez, Ivan, Calabuig Muñoz, Eva, Cuellar Tovar, Sandra, Salavert Lleti, Miguel, Fernandez Navarro, Juan, Gonzalez-garcia, Juan, Arnalich, Francisco, Ramon Arribas, Jose, Bernardino de la Serna, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontanon, Victor, Garcia-Bujalance, Silvia, Garcia Lopez-Hortelano, Milagros, Gonzalez-Baeza, Alicia, Martin-Carbonero, Maria Luz, Mayoral, Mario, Mellado, Maria Jose, Mican, Rafael Esteban, Montejano, Rocio, Montes, Maria Luisa, Moreno, Victoria, Perez-Valero, Ignacio, Rodes, Berta, Sainz, Talia, Sendagorta, Elena, Alcariz, Natalia Stella, Valencia, Eulalia, Blanco, Jose Ramon, Oteo, Jose Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Perez-Martinez, Laura, Jaen, Angels, Sanmarti, Montse, Cairo, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemi, Rivero, Maria, Reparaz, Jesus, Ruiz de Alda, Maria Gracia, de Leon Cano, Maria Teresa, Pierola Ruiz de Galarreta, Beatriz, Segura, Ferran, Amengual, Maria Jose, Navarro, Gemma, Sala, Montserrat, Cervantes, Manuel, Pineda, Valentin, Calzado, Sonia, Navarro, Marta, de los Santos, Ignacio, Sanz Sanz, Jesus, Salas Aparicio, Ana, Sarria Cepeda, Cristina, Garcia-Fraile Fraile, Lucio, Martin Gayo, Enrique, Casado, Jose Luis, Dronda, Fernando, Moreno, Ana, Perez Elias, Maria Jesus, Gomez Ayerbe, Cristina, Gutierrez, Carolina, Madrid, Nadia, del Campo Terron, Santos, Marti, Paloma, Ansa, Uxua, Serrano, Sergio, Vivancos, Maria Jesus, Bernal, Enrique, Cano, Alfredo, Alcaraz Garcia, Antonia, Bravo Urbieta, Joaquin, Munoz, Angeles, Alcaraz, Maria Jose, Villalba, Maria del Carmen, Hernandez, Jose, Pena, Alejandro, Munoz, Leopoldo, Casas, Paz, Alvarez, Marta, Chueca, Natalia, Vinuesa, David, Martinez-Montes, Clara, Del Romero, Jorge, Rodriguez, Carmen, Puerta, Teresa, Carrio, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Riera, Melchor, Peñaranda Vera, Maria, Leyes Garcia, Maria, Ribas, Maria Àngels, Campins Rosselló, Antoni, Vidal, Carme, Fanjul, Francisco, Murillas Angoiti, Javier, Homar, Francisco, Gomez Ayerbe, Crisitina, Viciana, Isabel, Palacios, Rosario, Gonzalez, Carmen Maria, Viciana, Pompeyo, Espinosa, Nuria, Lopez-Cortes, Luis Fernando, Podzamczer, Daniel, Ferrer, Elena, Imaz, Arkaitz, Tiraboschi, Juan, Silva, Ana, Saumoy, Maria, Olalla, Julian, del Arco, Alfonso, de la Torre, Javier, Luis Prada, Jose, Garcia de Lomas Guerrero, Jose Maria, Perez Stachowski, Javier, Juan Martinez, Onofre, Jesus Vera, Francisco, Martinez, Lorena, Garcia, Josefina, Alcaraz, Begona, Jimeno, Amaya, Castro Iglesias, Angeles, Pernas Souto, Berta, Mena de Cea, Alvaro, Galera, Carlos, Albendin, Helena, Perez, Aurora, Iborra, Asuncion, Moreno, Antonio, Merlos, Maria Angustias, Vidal, Asuncion, Suarez-Garcia, Ines, Malmierca, Eduardo, Gonzalez-Ruano, Patricia, Martin Rodrigo, Dolores, Ruiz Seco, Ma Pilar, Omar Mohamed-Balghata, Mohamed, Gomez Vidal, Maria Amparo, Estrada Perez, Vicente, Tellez Molina, Maria Jesus, Vergas Garcia, Jorge, Perez-Somarriba Moreno, Juncal, Cabello, Alfonso, Alvarez, Beatriz, Prieto, Laura, Galindo Puerto, Maria Jose, Fernando Vilalta, Ramon, Ferrer Ribera, Ana, Rivero Roman, Antonio, Brieva Herrero, Maria Teresa, Rivero Juarez, Antonio, Lopez Lopez, Pedro, Machuca Sanchez, Isabel, Pena Martinez, Jose, Cervero Jimenez, Miguel, Torres Perea, Rafael, Jusdado Ruiz-Capillas, Juan Jose, Pineda, Juan A., CoRIS HIV Biobank Integrated Spani
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/16530
Acceso en línea:https://hdl.handle.net/20.500.13003/16530
Access Level:acceso abierto
Palabra clave:Adult
Female
Anti-Retroviral Agents
Humans
Drug Interactions
Polymorphism, Single Nucleotide
CD4 Lymphocyte Count
Genotype
HIV Infections
Male
Receptors, Interleukin-7
Middle Aged
Masculino
Humanos
Persona de Mediana Edad
Polimorfismo de Nucleótido Simple
Antirretrovirales
Interacciones Farmacológicas
Genotipo
Recuento de Linfocito CD4
Femenino
Infecciones por VIH
Receptores de Interleucina-7
Adulto
HIV
IL7RA
SNPs
immune reconstitution
CD4
cART
Descripción
Sumario:Interleukin-7 receptor subunit alpha (IL7RA) rs6897932 polymorphism IS related to CD4(+) recovery after combination antiretroviral therapy (cART), but no studies so far have analyzed its potential impact in patients with very low CD4(+) T-cells count. We aimed to analyze the association between IL7RA rs6897932 polymorphism and CD4(+) T-cells count restoration in HIV-infected patients starting combination antiretroviral therapy (cART) with CD4(+) T-cells count <200 cells/mm(3). We performed a retrospective study in 411 patients followed for 24 months with a DNA sample available for genotyping. The change in CD4(+) T-cells count during the follow-up was considered as the primary outcome. The rs6897932 polymorphism had a minimum allele frequency (MAF) >20% and was in Hardy-Weinberg equilibrium (p = 0.550). Of 411 patients, 256 carried the CC genotype, while 155 had the CT/TT genotype. The CT/TT genotype was associated with a higher slope of CD4(+) T-cells recovery (arithmetic mean ratio; AMR = 1.16; p = 0.016), higher CD4(+) T-cells increase (AMR = 1.19; p = 0.004), and higher CD4(+) T-cells count at the end of follow-up (AMR = 1.13; p = 0.006). Besides, rs6897932 CT/TT was related to a higher odds of having a value of CD4(+) T-cells at the end of follow-up >= 500 CD4(+) cells/mm(3) (OR = 2.44; p = 0.006). After multiple testing correction (Benjamini-Hochberg), only the increase of >= 400 CD4(+) cells/mm(3) lost statistical significance (p = 0.052). IL7RA rs6897932 CT/TT genotype was related to a better CD4(+) T-cells recovery and it could be used to improve the management of HIV-infected patients starting cART with CD4(+) T-cells count <200 cells/mm(3).

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