Proteínas moonlighting en la invasión del huésped y evasión de su Sistema Inmunitario por parte de bacterias, ¿son las mismas que las utilizadas por células metastásicas?
Pathogenic bacteria and metastasic tumor cells try to spread to new parts of the human body and survive to the immune response. Since both need to overcome the same obstacles, the aim of the study is to find common characteristics between both processes, starting from the so called moonlighting prot...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Oberta de Catalunya (UOC) |
| Repositorio: | O2, repositorio institucional de la UOC |
| OAI Identifier: | oai:openaccess.uoc.edu:10609/120426 |
| Acceso en línea: | http://hdl.handle.net/10609/120426 |
| Access Level: | acceso abierto |
| Palabra clave: | proteínas moonlighting metástasis bacterias patógenas matriz extracelular proteïnes moonlighting metàstasi bacteris patògens matriu extracelul·lar pathogenic bacteria metastasi moonlighting proteins extracellular matrix Immune system -- TFM Sistema immunològic -- TFM Sistema inmunológico -- TFM |
| Sumario: | Pathogenic bacteria and metastasic tumor cells try to spread to new parts of the human body and survive to the immune response. Since both need to overcome the same obstacles, the aim of the study is to find common characteristics between both processes, starting from the so called moonlighting proteins. Moonlighting proteins are multifunctional proteins and in bacteria are usually virulence factors. Therefore, functions associated with them are related to the infection and survival of the pathogen. It is wanted to identify the functions that are mostly shared between virulence moonlighting proteins and metastasic proteins. In order to perform this comparison, metastasic proteins were divided according to the processes in which they were involved: glucose metabolism, remodeling/regeneration of tissues, interaction with plasminogen and interaction with extracellular matrix. Subsequently, their GO terms were compared to those of the moonlighting proteins, differentiating which of them were virulence factors. The results obtained showed that GO terms related to the binding to extracelullar matrix, such as collagen, fibronectin or laminin, are widely represented among virulence moonlighting proteins and metastasic proteins. Further investigation is needed to prove if the binding sites used by both types of proteins are the same, if they share binding sequences or to discover new blocker drugs specific of these binding sites. |
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