Site-Selective Functionalization of C(sp3) Vicinal Boronic Esters
Selective functionalization of the C-B bond in 1,2-bis(boronate) esters has emerged as a powerful tool to prepare 1,2-difunctionalized compounds with stereocontrol. Selective Suzuki cross-coupling, oxidation, amination, and homologation reactions serve as platforms to prepare a wide variety of compo...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/343627 |
| Acceso en línea: | http://hdl.handle.net/10261/343627 https://doi.org/10.1021/acscatal.2c02857 |
| Access Level: | acceso abierto |
| Palabra clave: | Boron Vicinal boronates Suzuki-Miyaura cross-coupling 1,2-shift Boronate allylation Site selective functionalization Boro-Wittig reaction |
| Sumario: | Selective functionalization of the C-B bond in 1,2-bis(boronate) esters has emerged as a powerful tool to prepare 1,2-difunctionalized compounds with stereocontrol. Selective Suzuki cross-coupling, oxidation, amination, and homologation reactions serve as platforms to prepare a wide variety of compounds from a common intermediate. The exquisite selectivity offered and their easy preparation from feedstock material using a myriad of catalytic transformations make them attractive building blocks for the preparation of complex molecules. In this Perspective, we summarize the examples of selective C-B bond functionalization of vicinal bis(boronates), attending to the nature of the C-B bond functionalization. |
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