Biocatalyzed synthesis of antidiabetic drugs: A review

The biocatalyzed production of building blocks for synthesizing drugs is a very attractive research field, because of the sustainability introduced in a synthetic schedule when chemical steps are substituted by biocatalyzed protocols. In this article, we will show how different antidiabetic drugs, f...

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Detalles Bibliográficos
Autores: Alcántara, Cristina M., Alcántara León, Andrés Rafael
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12055
Acceso en línea:https://hdl.handle.net/20.500.14352/12055
Access Level:acceso abierto
Palabra clave:547
616.379-008.64
Hypoglycemic agents
Diabetes
Enzymes
Drug marketing
Glucosidase inhibitors
Biocatalysis
Drugs
Green chemistry
Insulin analogues
Gastroenterología y hepatología
Farmacología (Farmacia)
Química orgánica (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/12055
network_acronym_str ES
network_name_str España
repository_id_str
spelling Biocatalyzed synthesis of antidiabetic drugs: A reviewAlcántara, Cristina M.Alcántara León, Andrés Rafael547616.379-008.64Hypoglycemic agentsDiabetesEnzymesDrug marketingGlucosidase inhibitorsBiocatalysisDrugsGreen chemistryInsulin analoguesGastroenterología y hepatologíaFarmacología (Farmacia)Química orgánica (Farmacia)3205.03 Gastroenterología3209 FarmacologíaThe biocatalyzed production of building blocks for synthesizing drugs is a very attractive research field, because of the sustainability introduced in a synthetic schedule when chemical steps are substituted by biocatalyzed protocols. In this article, we will show how different antidiabetic drugs, for treating diabetes mellitus Type 1 and Type 2, can be more efficiently and effectively synthetized with the help of different types of biocatalysts. The huge overall drug market for these drugs, as well as the great number of people suffering from diabetes (the prevalence of all types of diabetes is growing), makes this topic attractive enough to focus on more efficient synthetic protocols for preparing antidiabetic drugs. Examples covering biocatalyzed synthesis of insulin analogues, sensitizers (PPAR agonists), secretagogues (GLP-1 analogues, GPR119 agonists) and enzyme inhibitors (α-glucosidase inhibitors, DPP4-inhibitors, SGLT-2 inhibitors and 11β-HSD1 inhibitors) will be presented.Taylor & FrancisUniversidad Complutense de Madrid20182018-02-0120182018-02-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12055reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/120552026-06-02T12:44:21Z
dc.title.none.fl_str_mv Biocatalyzed synthesis of antidiabetic drugs: A review
title Biocatalyzed synthesis of antidiabetic drugs: A review
spellingShingle Biocatalyzed synthesis of antidiabetic drugs: A review
Alcántara, Cristina M.
547
616.379-008.64
Hypoglycemic agents
Diabetes
Enzymes
Drug marketing
Glucosidase inhibitors
Biocatalysis
Drugs
Green chemistry
Insulin analogues
Gastroenterología y hepatología
Farmacología (Farmacia)
Química orgánica (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
title_short Biocatalyzed synthesis of antidiabetic drugs: A review
title_full Biocatalyzed synthesis of antidiabetic drugs: A review
title_fullStr Biocatalyzed synthesis of antidiabetic drugs: A review
title_full_unstemmed Biocatalyzed synthesis of antidiabetic drugs: A review
title_sort Biocatalyzed synthesis of antidiabetic drugs: A review
dc.creator.none.fl_str_mv Alcántara, Cristina M.
Alcántara León, Andrés Rafael
author Alcántara, Cristina M.
author_facet Alcántara, Cristina M.
Alcántara León, Andrés Rafael
author_role author
author2 Alcántara León, Andrés Rafael
author2_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 547
616.379-008.64
Hypoglycemic agents
Diabetes
Enzymes
Drug marketing
Glucosidase inhibitors
Biocatalysis
Drugs
Green chemistry
Insulin analogues
Gastroenterología y hepatología
Farmacología (Farmacia)
Química orgánica (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
topic 547
616.379-008.64
Hypoglycemic agents
Diabetes
Enzymes
Drug marketing
Glucosidase inhibitors
Biocatalysis
Drugs
Green chemistry
Insulin analogues
Gastroenterología y hepatología
Farmacología (Farmacia)
Química orgánica (Farmacia)
3205.03 Gastroenterología
3209 Farmacología
description The biocatalyzed production of building blocks for synthesizing drugs is a very attractive research field, because of the sustainability introduced in a synthetic schedule when chemical steps are substituted by biocatalyzed protocols. In this article, we will show how different antidiabetic drugs, for treating diabetes mellitus Type 1 and Type 2, can be more efficiently and effectively synthetized with the help of different types of biocatalysts. The huge overall drug market for these drugs, as well as the great number of people suffering from diabetes (the prevalence of all types of diabetes is growing), makes this topic attractive enough to focus on more efficient synthetic protocols for preparing antidiabetic drugs. Examples covering biocatalyzed synthesis of insulin analogues, sensitizers (PPAR agonists), secretagogues (GLP-1 analogues, GPR119 agonists) and enzyme inhibitors (α-glucosidase inhibitors, DPP4-inhibitors, SGLT-2 inhibitors and 11β-HSD1 inhibitors) will be presented.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-02-01
2018
2018-02-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12055
url https://hdl.handle.net/20.500.14352/12055
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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