Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk
Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperurice...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/18466 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/18466 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardiovascular Diseases Uric Acid Male Hyperuricemia Polyphenols Female Risk Factors Heart Disease Risk Factors Hydroxybenzoates Humans Coumaric Acids Cross-Sectional Studies Hidroxibenzoatos Estudios Transversales Factores de Riesgo Polifenoles Humanos Factores de Riesgo de Enfermedad Cardiaca Femenino Enfermedades Cardiovasculares Ácido Úrico Ácidos Cumáricos Hiperuricemia Masculino |
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Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular RiskRubín-García, MaríaVitelli Storelli, FacundoÁlvarez-Álvarez, LauraMartínez-González, Miguel ÁngelSalas-Salvado, JordiCorella, DoloresHernaez, AlvaroMartínez, J AlfredoAlonso-Gomez, Angel M.Wärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JSerra-Majem, LluisCano-Ibáñez, NaomiTur, Josep A.Marcos-Delgado, AlbaTresserra-Rimbau, AnnaPintó, XavierDelgado-Rodriguez, MiguelMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmilioVazquez-Ruiz, ZenaidaBabio, NancyBarragán, RocíoCastañer-Niño, OlgaRazquin, CristinaTojal-Sierra, LucasGómez-Gracia, EnriqueGonzález-Palacios, SandraMorey, MargalidaGarcía-Rios, AntonioCastro-Barquero, SaraRosa Bernal-Lopez, MariaSantos-Lozano, José ManuelRuiz-Canela, MiguelCastro-Salomó, AntoniPascual-Castelló, Eva CristinaMoldon, VerónicaBullón-Vela, VanessaSorto-Sanchez, CarolinaCenoz-Osinaga, Juan CarlosGutiérrez, LilianaMengual, MairaLamuela-Raventós, Rosa MaríaMartín-Sánchez, VicenteCardiovascular DiseasesUric AcidMaleHyperuricemiaPolyphenolsFemaleRisk FactorsHeart Disease Risk FactorsHydroxybenzoatesHumansCoumaric AcidsCross-Sectional StudiesHidroxibenzoatosEstudios TransversalesFactores de RiesgoPolifenolesHumanosFactores de Riesgo de Enfermedad CardiacaFemeninoEnfermedades CardiovascularesÁcido ÚricoÁcidos CumáricosHiperuricemiaMasculinoBackground Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.20222022-10-1820222022-10-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/18466reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/184662026-06-22T12:44:07Z |
| dc.title.none.fl_str_mv |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| title |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| spellingShingle |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk Rubín-García, María Cardiovascular Diseases Uric Acid Male Hyperuricemia Polyphenols Female Risk Factors Heart Disease Risk Factors Hydroxybenzoates Humans Coumaric Acids Cross-Sectional Studies Hidroxibenzoatos Estudios Transversales Factores de Riesgo Polifenoles Humanos Factores de Riesgo de Enfermedad Cardiaca Femenino Enfermedades Cardiovasculares Ácido Úrico Ácidos Cumáricos Hiperuricemia Masculino |
| title_short |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| title_full |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| title_fullStr |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| title_full_unstemmed |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| title_sort |
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk |
| dc.creator.none.fl_str_mv |
Rubín-García, María Vitelli Storelli, Facundo Álvarez-Álvarez, Laura Martínez-González, Miguel Ángel Salas-Salvado, Jordi Corella, Dolores Hernaez, Alvaro Martínez, J Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Serra-Majem, Lluis Cano-Ibáñez, Naomi Tur, Josep A. Marcos-Delgado, Alba Tresserra-Rimbau, Anna Pintó, Xavier Delgado-Rodriguez, Miguel Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Vazquez-Ruiz, Zenaida Babio, Nancy Barragán, Rocío Castañer-Niño, Olga Razquin, Cristina Tojal-Sierra, Lucas Gómez-Gracia, Enrique González-Palacios, Sandra Morey, Margalida García-Rios, Antonio Castro-Barquero, Sara Rosa Bernal-Lopez, Maria Santos-Lozano, José Manuel Ruiz-Canela, Miguel Castro-Salomó, Antoni Pascual-Castelló, Eva Cristina Moldon, Verónica Bullón-Vela, Vanessa Sorto-Sanchez, Carolina Cenoz-Osinaga, Juan Carlos Gutiérrez, Liliana Mengual, Maira Lamuela-Raventós, Rosa María Martín-Sánchez, Vicente |
| author |
Rubín-García, María |
| author_facet |
Rubín-García, María Vitelli Storelli, Facundo Álvarez-Álvarez, Laura Martínez-González, Miguel Ángel Salas-Salvado, Jordi Corella, Dolores Hernaez, Alvaro Martínez, J Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Serra-Majem, Lluis Cano-Ibáñez, Naomi Tur, Josep A. Marcos-Delgado, Alba Tresserra-Rimbau, Anna Pintó, Xavier Delgado-Rodriguez, Miguel Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Vazquez-Ruiz, Zenaida Babio, Nancy Barragán, Rocío Castañer-Niño, Olga Razquin, Cristina Tojal-Sierra, Lucas Gómez-Gracia, Enrique González-Palacios, Sandra Morey, Margalida García-Rios, Antonio Castro-Barquero, Sara Rosa Bernal-Lopez, Maria Santos-Lozano, José Manuel Ruiz-Canela, Miguel Castro-Salomó, Antoni Pascual-Castelló, Eva Cristina Moldon, Verónica Bullón-Vela, Vanessa Sorto-Sanchez, Carolina Cenoz-Osinaga, Juan Carlos Gutiérrez, Liliana Mengual, Maira Lamuela-Raventós, Rosa María Martín-Sánchez, Vicente |
| author_role |
author |
| author2 |
Vitelli Storelli, Facundo Álvarez-Álvarez, Laura Martínez-González, Miguel Ángel Salas-Salvado, Jordi Corella, Dolores Hernaez, Alvaro Martínez, J Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Serra-Majem, Lluis Cano-Ibáñez, Naomi Tur, Josep A. Marcos-Delgado, Alba Tresserra-Rimbau, Anna Pintó, Xavier Delgado-Rodriguez, Miguel Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Vazquez-Ruiz, Zenaida Babio, Nancy Barragán, Rocío Castañer-Niño, Olga Razquin, Cristina Tojal-Sierra, Lucas Gómez-Gracia, Enrique González-Palacios, Sandra Morey, Margalida García-Rios, Antonio Castro-Barquero, Sara Rosa Bernal-Lopez, Maria Santos-Lozano, José Manuel Ruiz-Canela, Miguel Castro-Salomó, Antoni Pascual-Castelló, Eva Cristina Moldon, Verónica Bullón-Vela, Vanessa Sorto-Sanchez, Carolina Cenoz-Osinaga, Juan Carlos Gutiérrez, Liliana Mengual, Maira Lamuela-Raventós, Rosa María Martín-Sánchez, Vicente |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Cardiovascular Diseases Uric Acid Male Hyperuricemia Polyphenols Female Risk Factors Heart Disease Risk Factors Hydroxybenzoates Humans Coumaric Acids Cross-Sectional Studies Hidroxibenzoatos Estudios Transversales Factores de Riesgo Polifenoles Humanos Factores de Riesgo de Enfermedad Cardiaca Femenino Enfermedades Cardiovasculares Ácido Úrico Ácidos Cumáricos Hiperuricemia Masculino |
| topic |
Cardiovascular Diseases Uric Acid Male Hyperuricemia Polyphenols Female Risk Factors Heart Disease Risk Factors Hydroxybenzoates Humans Coumaric Acids Cross-Sectional Studies Hidroxibenzoatos Estudios Transversales Factores de Riesgo Polifenoles Humanos Factores de Riesgo de Enfermedad Cardiaca Femenino Enfermedades Cardiovasculares Ácido Úrico Ácidos Cumáricos Hiperuricemia Masculino |
| description |
Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-10-18 2022 2022-10-18 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.13003/18466 |
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https://hdl.handle.net/20.500.13003/18466 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 4.0 Internacional http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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