Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperurice...

Descripción completa

Detalles Bibliográficos
Autores: Rubín-García, María, Vitelli Storelli, Facundo, Álvarez-Álvarez, Laura, Martínez-González, Miguel Ángel, Salas-Salvado, Jordi, Corella, Dolores, Hernaez, Alvaro, Martínez, J Alfredo, Alonso-Gomez, Angel M., Wärnberg, Julia, Vioque, Jesus, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Serra-Majem, Lluis, Cano-Ibáñez, Naomi, Tur, Josep A., Marcos-Delgado, Alba, Tresserra-Rimbau, Anna, Pintó, Xavier, Delgado-Rodriguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vazquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Vazquez-Ruiz, Zenaida, Babio, Nancy, Barragán, Rocío, Castañer-Niño, Olga, Razquin, Cristina, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, González-Palacios, Sandra, Morey, Margalida, García-Rios, Antonio, Castro-Barquero, Sara, Rosa Bernal-Lopez, Maria, Santos-Lozano, José Manuel, Ruiz-Canela, Miguel, Castro-Salomó, Antoni, Pascual-Castelló, Eva Cristina, Moldon, Verónica, Bullón-Vela, Vanessa, Sorto-Sanchez, Carolina, Cenoz-Osinaga, Juan Carlos, Gutiérrez, Liliana, Mengual, Maira, Lamuela-Raventós, Rosa María, Martín-Sánchez, Vicente
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/18466
Acceso en línea:https://hdl.handle.net/20.500.13003/18466
Access Level:acceso abierto
Palabra clave:Cardiovascular Diseases
Uric Acid
Male
Hyperuricemia
Polyphenols
Female
Risk Factors
Heart Disease Risk Factors
Hydroxybenzoates
Humans
Coumaric Acids
Cross-Sectional Studies
Hidroxibenzoatos
Estudios Transversales
Factores de Riesgo
Polifenoles
Humanos
Factores de Riesgo de Enfermedad Cardiaca
Femenino
Enfermedades Cardiovasculares
Ácido Úrico
Ácidos Cumáricos
Hiperuricemia
Masculino
Descripción
Sumario:Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.

Similares en LA Referencia