Sex dimorphism in the myocardial response to aortic stenosis

Objectives: The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers. Background: AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are repo...

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Detalles Bibliográficos
Autores: Treibel, T.A. (Thomas A.)|||/items/07a51ca9-29c4-42e6-856e-db9593c33fd4, Kozor, R. (Rebecca)|||/items/6ecbcd45-bfa1-4942-9d89-f47001ddcb77, Fontana, M. (Marianna)|||/items/c282fcc9-f89e-476a-b5a4-87b3f6e3849a, Torlasco, C. (Camilla)|||/items/5ff3c6e8-db04-4990-8393-d32d0d313f4a, Reant, P. (Patricia)|||/items/0b1930f8-0161-46bd-8f52-b1eb409e2b04, Badiani, S. (Sveeta)|||/items/a796a360-47a6-4c38-82a1-7744ddecb508, Espinoza, M. (Maria)|||/items/1ede50e2-e33e-43d9-bbd4-a906d25590ad, Yap, J. (John)|||/items/2a75d28e-7ade-44ee-8752-9128b5044bd0, Diez, J. (Javier)|||/items/adeda0be-cebc-4240-899c-ab26f05dea9c, Hughes, A.D. (Alun D.)|||/items/056a18d3-dc34-4092-a250-ec7298d65a23, Lloyd, G. (Guy)|||/items/a25f3969-46d5-41f7-a4ef-cc980052053c, Moon, J.C. (James C.)|||/items/7c39855a-3b38-428d-b08e-379caa124ea3
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/65821
Acceso en línea:https://hdl.handle.net/10171/65821
Access Level:acceso abierto
Palabra clave:Aortic stenosis
Fibrosis
Ventricular hypertrophy
Descripción
Sumario:Objectives: The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers. Background: AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are reported in AS and may play a role in disease phenotyping. Methods: This study was a prospective assessment of patients awaiting surgical valve replacement for severe AS using echocardiography, the 6-min walking test, biomarkers (high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide), and CMR with late gadolinium enhancement and extracellular volume fraction, which dichotomizes the myocardium into matrix and cell volumes. LV remodeling was categorized into normal geometry, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy.

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