Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health

Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcom...

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Autores: Forner, Mar, 1980-, Cañas Arranz, Rodrigo, Defaus, Sira, de León, Patricia, Rodríguez Pulido, Miguel, Ganges, Lliliane, Blanco, Esther, Sobrino, Francisco, Andreu Martínez, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/48310
Acceso en línea:http://hdl.handle.net/10230/48310
http://dx.doi.org/10.3390/vaccines9050477
Access Level:acceso abierto
Palabra clave:FMDV
Epitope-based vaccines
Peptide
Vaccines
Veterinary medicine
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spelling Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal healthForner, Mar, 1980-Cañas Arranz, RodrigoDefaus, Sirade León, PatriciaRodríguez Pulido, MiguelGanges, LlilianeBlanco, EstherSobrino, FranciscoAndreu Martínez, DavidFMDVEpitope-based vaccinesPeptideVaccinesVeterinary medicineVaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.This research was funded by the European Commission (project H2020-FETOPEN-2018-2019-2020-01 n° 828774), by the Spanish Ministry of Science, Innovation and Universities, grants AGL2014-48923-C2 and AGL2017-84097-C2-2-R (to D.A. and F.S.), and AGL2016-349 76445-R (to E.B.), as well as by Comunidad de Madrid co-financed ECFEDER funds (S2013/ABI-350 2906-PLATESA and P2018/BAA-4370 to F.S. and E.B.), and by Generalitat de Catalunya (2009SGR492 to D.A.). Work at Centro de Biología Molecular “Severo Ochoa” and at UPF was supported by Fundación Ramón Areces and by the Maria de Maeztu Program of the Spanish Ministry of Science, Innovation and Universities, respectively. M.F. and R.C.-A. were holders of a PhD fellowship from the Spanish Ministry of Science, Innovation and Universities.MDPI202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48310http://dx.doi.org/10.3390/vaccines9050477reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVaccines (Basel). 2021;9(5):477info:eu-repo/grantAgreement/EC/H2020/828774info:eu-repo/grantAgreement/ES/1PE/AGL2014-48923-C2info:eu-repo/grantAgreement/ES/2PE/AGL2017-84097-C2-2-Rinfo:eu-repo/grantAgreement/ES/1PE/AGL2016-349 76445-R© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/483102026-05-29T05:05:01Z
dc.title.none.fl_str_mv Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
title Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
spellingShingle Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
Forner, Mar, 1980-
FMDV
Epitope-based vaccines
Peptide
Vaccines
Veterinary medicine
title_short Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
title_full Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
title_fullStr Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
title_full_unstemmed Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
title_sort Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
dc.creator.none.fl_str_mv Forner, Mar, 1980-
Cañas Arranz, Rodrigo
Defaus, Sira
de León, Patricia
Rodríguez Pulido, Miguel
Ganges, Lliliane
Blanco, Esther
Sobrino, Francisco
Andreu Martínez, David
author Forner, Mar, 1980-
author_facet Forner, Mar, 1980-
Cañas Arranz, Rodrigo
Defaus, Sira
de León, Patricia
Rodríguez Pulido, Miguel
Ganges, Lliliane
Blanco, Esther
Sobrino, Francisco
Andreu Martínez, David
author_role author
author2 Cañas Arranz, Rodrigo
Defaus, Sira
de León, Patricia
Rodríguez Pulido, Miguel
Ganges, Lliliane
Blanco, Esther
Sobrino, Francisco
Andreu Martínez, David
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FMDV
Epitope-based vaccines
Peptide
Vaccines
Veterinary medicine
topic FMDV
Epitope-based vaccines
Peptide
Vaccines
Veterinary medicine
description Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48310
http://dx.doi.org/10.3390/vaccines9050477
url http://hdl.handle.net/10230/48310
http://dx.doi.org/10.3390/vaccines9050477
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Vaccines (Basel). 2021;9(5):477
info:eu-repo/grantAgreement/EC/H2020/828774
info:eu-repo/grantAgreement/ES/1PE/AGL2014-48923-C2
info:eu-repo/grantAgreement/ES/2PE/AGL2017-84097-C2-2-R
info:eu-repo/grantAgreement/ES/1PE/AGL2016-349 76445-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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