Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice

Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study inves...

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Autores: Claro Cala, Carmen María, Quintela, José Carlos, Pérez Montero , Marta, Álvarez de Sotomayor Paz, María, Miñano Sánchez, Francisco Javier, Herrera González, María Dolores, Rodríguez Rodríguez , Rosalía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/92812
Acceso en línea:https://hdl.handle.net/11441/92812
https://doi.org/10.3390/nu12020323
Access Level:acceso abierto
Palabra clave:Mediterranean diet
maslinic acid
obesity
oleanolic acid
pomace olive oil
vascular function
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spelling Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in MiceClaro Cala, Carmen MaríaQuintela, José CarlosPérez Montero , MartaÁlvarez de Sotomayor Paz, MaríaMiñano Sánchez, Francisco JavierHerrera González, María DoloresRodríguez Rodríguez , RosalíaMediterranean dietmaslinic acidobesityoleanolic acidpomace olive oilvascular functionPomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean dietSpanish Ministerio de Economía, Industria y Competitividad (MINECO), Agencia Estatal de Investigación (AEI), and Fondo Europeo de Desarrollo Regional (FEDER) (Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R.)MDPIFarmacología2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/92812https://doi.org/10.3390/nu12020323reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNutrients, 12 (2), 1-13.Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R.http://dx.doi.org/10.3390/nu12020323info:eu-repo/semantics/openAccessoai:idus.us.es:11441/928122026-06-17T12:51:07Z
dc.title.none.fl_str_mv Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
title Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
spellingShingle Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
Claro Cala, Carmen María
Mediterranean diet
maslinic acid
obesity
oleanolic acid
pomace olive oil
vascular function
title_short Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
title_full Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
title_fullStr Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
title_full_unstemmed Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
title_sort Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice
dc.creator.none.fl_str_mv Claro Cala, Carmen María
Quintela, José Carlos
Pérez Montero , Marta
Álvarez de Sotomayor Paz, María
Miñano Sánchez, Francisco Javier
Herrera González, María Dolores
Rodríguez Rodríguez , Rosalía
author Claro Cala, Carmen María
author_facet Claro Cala, Carmen María
Quintela, José Carlos
Pérez Montero , Marta
Álvarez de Sotomayor Paz, María
Miñano Sánchez, Francisco Javier
Herrera González, María Dolores
Rodríguez Rodríguez , Rosalía
author_role author
author2 Quintela, José Carlos
Pérez Montero , Marta
Álvarez de Sotomayor Paz, María
Miñano Sánchez, Francisco Javier
Herrera González, María Dolores
Rodríguez Rodríguez , Rosalía
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Farmacología
dc.subject.none.fl_str_mv Mediterranean diet
maslinic acid
obesity
oleanolic acid
pomace olive oil
vascular function
topic Mediterranean diet
maslinic acid
obesity
oleanolic acid
pomace olive oil
vascular function
description Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on metabolic complications of obesity, this study investigates for the first time the dietary intervention with a pomace olive oil with high concentrations of the triterpenic acids (POCTA), oleanolic and maslinic acid, during diet-induced obesity in mice. The results demonstrate that obese mice, when switched to a POCTA-diet for 10 weeks, show a substantial reduction of body weight, insulin resistance, adipose tissue inflammation, and particularly, improvement of vascular function despite high caloric intake. This study reveals the potential of a functional food based on pomace olive oil and its triterpenic fraction against obesity progression. Our data also contribute to understanding the health-promoting effects attributable to the Mediterranean diet
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/92812
https://doi.org/10.3390/nu12020323
url https://hdl.handle.net/11441/92812
https://doi.org/10.3390/nu12020323
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients, 12 (2), 1-13.
Grants SAF2017-82813-C3-3-R and PCI2018-092997/AEI to R.R.-R.
http://dx.doi.org/10.3390/nu12020323
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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