Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets

BACKGROUND: Riboflavin and UV light-based pathogen reduction technology (PRT) and cold-stored platelets (CSP) have a significant impact on platelet (PLT) function. The aim of this study is to determine whether the use of both methods is beneficial. MATERIALS AND METHODS: Twenty buffy coat (BC) PLT c...

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Authors: Jimenez-Marco, Teresa, Torres-Reverte, Natalia, Quetglas-Oliver, Miguel, Morell-Garcia, Daniel, Ballester-Servera, Carme
Format: article
Publication Date:2026
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:dnet:docusalut___::f9766a5337493752210ad5662f8135e1
Online Access:https://hdl.handle.net/20.500.13003/27342
Access Level:Open access
Keyword:Cold-stored platelets
Pathogen reduction
Riboflavin and UV light
Platelet storage
Platelet quality
Platelet function
Transfusion medicine
Untreated platelets
Blood component storage
Photochemical treatment
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spelling Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored plateletsJimenez-Marco, TeresaTorres-Reverte, NataliaQuetglas-Oliver, MiguelMorell-Garcia, DanielBallester-Servera, CarmeCold-stored plateletsPathogen reductionRiboflavin and UV lightPlatelet storagePlatelet qualityPlatelet functionTransfusion medicineUntreated plateletsBlood component storagePhotochemical treatmentBACKGROUND: Riboflavin and UV light-based pathogen reduction technology (PRT) and cold-stored platelets (CSP) have a significant impact on platelet (PLT) function. The aim of this study is to determine whether the use of both methods is beneficial. MATERIALS AND METHODS: Twenty buffy coat (BC) PLT concentrates were grouped into 10 type-matched pairs, which were pooled and split into 10 non-PRT-treated PLTs and 10 PRT-treated PLTs, diluted in platelet additive solution (PAS-E) and leuko-reduced. Both groups were cold-stored at 2-6ºC without agitation for 14 days (non-PRT CSP and PRT CSP). Hemostatic function and metabolic parameters were monitored on day 1 pre-refrigeration and on days 3, 7 and 14 of cold storage. RESULTS: No swirling and no aggregates were observed at any time in either group after cold storage for 14 days. PRT CSP were less metabolically active (with better pH, lower lactate, lower pCO and higher pO) than non-PRT CSP (p<0.001) after 14 days of cold storage. PRT CSP and non-PRT CSP resulted in faster clot formation over storage (p<0.001). Clot strength was reduced under optimal levels on day 14 in the PRT CSP (p<0.001). DISCUSSION: The enhanced hemostatic PLT function achieved by CSP, i.e., faster clot formation, is also maintained by riboflavin and UV light treatment. The combination of riboflavin and UV light-based PRT and CSP has the added benefit of reducing platelet metabolism, which may have a positive effect on PLT viability. Further research is required to assess whether the in vitro benefits of combining PRT and CSP are confirmed in clinical trials.20262026-01-0120262026-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/27342reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:docusalut___::f9766a5337493752210ad5662f8135e12026-06-22T12:44:07Z
dc.title.none.fl_str_mv Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
title Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
spellingShingle Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
Jimenez-Marco, Teresa
Cold-stored platelets
Pathogen reduction
Riboflavin and UV light
Platelet storage
Platelet quality
Platelet function
Transfusion medicine
Untreated platelets
Blood component storage
Photochemical treatment
title_short Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
title_full Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
title_fullStr Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
title_full_unstemmed Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
title_sort Comparison between cold-stored platelets treated with riboflavin and UV light versus untreated cold-stored platelets
dc.creator.none.fl_str_mv Jimenez-Marco, Teresa
Torres-Reverte, Natalia
Quetglas-Oliver, Miguel
Morell-Garcia, Daniel
Ballester-Servera, Carme
author Jimenez-Marco, Teresa
author_facet Jimenez-Marco, Teresa
Torres-Reverte, Natalia
Quetglas-Oliver, Miguel
Morell-Garcia, Daniel
Ballester-Servera, Carme
author_role author
author2 Torres-Reverte, Natalia
Quetglas-Oliver, Miguel
Morell-Garcia, Daniel
Ballester-Servera, Carme
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Cold-stored platelets
Pathogen reduction
Riboflavin and UV light
Platelet storage
Platelet quality
Platelet function
Transfusion medicine
Untreated platelets
Blood component storage
Photochemical treatment
topic Cold-stored platelets
Pathogen reduction
Riboflavin and UV light
Platelet storage
Platelet quality
Platelet function
Transfusion medicine
Untreated platelets
Blood component storage
Photochemical treatment
description BACKGROUND: Riboflavin and UV light-based pathogen reduction technology (PRT) and cold-stored platelets (CSP) have a significant impact on platelet (PLT) function. The aim of this study is to determine whether the use of both methods is beneficial. MATERIALS AND METHODS: Twenty buffy coat (BC) PLT concentrates were grouped into 10 type-matched pairs, which were pooled and split into 10 non-PRT-treated PLTs and 10 PRT-treated PLTs, diluted in platelet additive solution (PAS-E) and leuko-reduced. Both groups were cold-stored at 2-6ºC without agitation for 14 days (non-PRT CSP and PRT CSP). Hemostatic function and metabolic parameters were monitored on day 1 pre-refrigeration and on days 3, 7 and 14 of cold storage. RESULTS: No swirling and no aggregates were observed at any time in either group after cold storage for 14 days. PRT CSP were less metabolically active (with better pH, lower lactate, lower pCO and higher pO) than non-PRT CSP (p<0.001) after 14 days of cold storage. PRT CSP and non-PRT CSP resulted in faster clot formation over storage (p<0.001). Clot strength was reduced under optimal levels on day 14 in the PRT CSP (p<0.001). DISCUSSION: The enhanced hemostatic PLT function achieved by CSP, i.e., faster clot formation, is also maintained by riboflavin and UV light treatment. The combination of riboflavin and UV light-based PRT and CSP has the added benefit of reducing platelet metabolism, which may have a positive effect on PLT viability. Further research is required to assess whether the in vitro benefits of combining PRT and CSP are confirmed in clinical trials.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-01-01
2026
2026-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/27342
url https://hdl.handle.net/20.500.13003/27342
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409435978301440
score 15,812429

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