Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control

Diabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel...

Descripción completa

Detalles Bibliográficos
Autores: Muñoz-Galán, Helena, Enshaei, Hamidreza, Silva, João C., Esteves, Teresa, Castelo Ferreira, Frederico, Casanovas Salas, Jordi, Worch, Joshua C., Dove, Andrew P., Alemán, Carlos, Pérez-Madrigal, Maria M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/467698
Acceso en línea:https://doi.org/10.1021/acsapm.4c00911
https://hdl.handle.net/10459.1/467698
Access Level:acceso abierto
Palabra clave:Electroactive click-hydrogel
Thiol−yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
id ES_60f6b53cbe729e6fb68aa2de4a3c970f
oai_identifier_str oai:repositori.udl.cat:10459.1/467698
network_acronym_str ES
network_name_str España
repository_id_str
spelling Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage ControlMuñoz-Galán, HelenaEnshaei, HamidrezaSilva, João C.Esteves, TeresaCastelo Ferreira, FredericoCasanovas Salas, JordiWorch, Joshua C.Dove, Andrew P.Alemán, CarlosPérez-Madrigal, Maria M.Electroactive click-hydrogelThiol−yne nucleophilic additionPEDOT nanoparticlesInsulin deliveryBioelectronicsDiabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option to administrate insulin. Most importantly, the device is rendered electroactive by incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) as conductive moieties to precisely control the release of insulin over an extended period through electrochemical stimulation (ES). The device has been carefully optimized on account of: (i) the main interactions established between PEDOT- and PEG-based moieties, which have been studied by density functional theory calculations, and reveal the choice of 4-arm PEG precursors as most suitable cross-linkers; and (ii) the concentration of PEDOT NPs in the device, which has been determined considering minimal interference with the gelation process, as well as the resulting morphological, mechanical, electrochemical, and cytocompatible properties of the PEG-based click-hydrogels. Finally, the management over insulin delivery through ES is verified in vitro, with released insulin being detected by high-performance liquid chromatography. Overall, our hydrogel-based device establishes a method for controlled insulin delivery with the potential for translation to other relevant bioelectronic applications.American Chemical Society2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1021/acsapm.4c00911https://hdl.handle.net/10459.1/467698reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.1021/acsapm.4c00911ACS Applied Polymer Materials, 2024, vol. 6, núm. 14, p. 8093-8104cc-by (c) American Chemical Society, 2024Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4676982026-06-24T12:42:17Z
dc.title.none.fl_str_mv Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
title Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
spellingShingle Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
Muñoz-Galán, Helena
Electroactive click-hydrogel
Thiol−yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
title_short Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
title_full Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
title_fullStr Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
title_full_unstemmed Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
title_sort Electroresponsive Thiol–Yne Click-Hydrogels for Insulin Smart Delivery: Tackling Sustained Release and Leakage Control
dc.creator.none.fl_str_mv Muñoz-Galán, Helena
Enshaei, Hamidreza
Silva, João C.
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Salas, Jordi
Worch, Joshua C.
Dove, Andrew P.
Alemán, Carlos
Pérez-Madrigal, Maria M.
author Muñoz-Galán, Helena
author_facet Muñoz-Galán, Helena
Enshaei, Hamidreza
Silva, João C.
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Salas, Jordi
Worch, Joshua C.
Dove, Andrew P.
Alemán, Carlos
Pérez-Madrigal, Maria M.
author_role author
author2 Enshaei, Hamidreza
Silva, João C.
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Salas, Jordi
Worch, Joshua C.
Dove, Andrew P.
Alemán, Carlos
Pérez-Madrigal, Maria M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Electroactive click-hydrogel
Thiol−yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
topic Electroactive click-hydrogel
Thiol−yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
description Diabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option to administrate insulin. Most importantly, the device is rendered electroactive by incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) as conductive moieties to precisely control the release of insulin over an extended period through electrochemical stimulation (ES). The device has been carefully optimized on account of: (i) the main interactions established between PEDOT- and PEG-based moieties, which have been studied by density functional theory calculations, and reveal the choice of 4-arm PEG precursors as most suitable cross-linkers; and (ii) the concentration of PEDOT NPs in the device, which has been determined considering minimal interference with the gelation process, as well as the resulting morphological, mechanical, electrochemical, and cytocompatible properties of the PEG-based click-hydrogels. Finally, the management over insulin delivery through ES is verified in vitro, with released insulin being detected by high-performance liquid chromatography. Overall, our hydrogel-based device establishes a method for controlled insulin delivery with the potential for translation to other relevant bioelectronic applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1021/acsapm.4c00911
https://hdl.handle.net/10459.1/467698
url https://doi.org/10.1021/acsapm.4c00911
https://hdl.handle.net/10459.1/467698
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1021/acsapm.4c00911
ACS Applied Polymer Materials, 2024, vol. 6, núm. 14, p. 8093-8104
dc.rights.none.fl_str_mv cc-by (c) American Chemical Society, 2024
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) American Chemical Society, 2024
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409357726220288
score 15,198674

Similares en LA Referencia