Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.

Purpose To study the impact of advanced paternal age on embryo aneuploidy. Methods This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing...

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Autores: Carrasquillo, Robert J, Kohn, Taylor P, Cinnioglu, Cengiz, Rubio, Carmen, Simon, Carlos, Ramasamy, Ranjith, Al-Asmar, Nasser
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p3963
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/3963
Access Level:acceso abierto
Palabra clave:Advanced paternal age
Advanced maternal age
Aneuploidy
In vitro fertilization
Egg donor
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spelling Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.Carrasquillo, Robert JKohn, Taylor PCinnioglu, CengizRubio, CarmenSimon, CarlosRamasamy, RanjithAl-Asmar, NasserAdvanced paternal ageAdvanced maternal ageAneuploidyIn vitro fertilizationEgg donorPurpose To study the impact of advanced paternal age on embryo aneuploidy. Methods This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing for aneuploidy via next-generation sequencing at Igenomix reproductive testing centers. The main outcome measure was the prevalence of embryo aneuploidy in egg donor cycles. Semen analysis data was retrieved for a small subset of the male patients. Results Data from 1202 IVF/ICSI egg donor cycles using ejaculated sperm (total 6934 embryos) evaluated using PGT-A between January 2016 and April 2018 in a global population across all Igenomix centers were included. No significant association was identified between advancing paternal age and the prevalence of embryo aneuploidy overall and when analyzing for each chromosome. There was also no significant association between advancing paternal age and specific aneuploid conditions (monosomy, trisomy, partial deletion/duplication) for all chromosomes in the genome. Conclusions This is the largest study of its kind in an international patient population to evaluate the impact of advancing paternal age on embryo aneuploidy. We conclude there is no specific effect of paternal age on the prevalence of embryo aneuploidy in the context of embryo biopsies from egg donor cycles.SPRINGER/PLENUM PUBLISHERS2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/3963JOURNAL OF ASSISTED REPRODUCTION AND GENETICSISSN: 10580468ISSNe: 15737330reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p39632026-06-07T16:35:31Z
dc.title.none.fl_str_mv Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
title Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
spellingShingle Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
Carrasquillo, Robert J
Advanced paternal age
Advanced maternal age
Aneuploidy
In vitro fertilization
Egg donor
title_short Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
title_full Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
title_fullStr Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
title_full_unstemmed Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
title_sort Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles.
dc.creator.none.fl_str_mv Carrasquillo, Robert J
Kohn, Taylor P
Cinnioglu, Cengiz
Rubio, Carmen
Simon, Carlos
Ramasamy, Ranjith
Al-Asmar, Nasser
author Carrasquillo, Robert J
author_facet Carrasquillo, Robert J
Kohn, Taylor P
Cinnioglu, Cengiz
Rubio, Carmen
Simon, Carlos
Ramasamy, Ranjith
Al-Asmar, Nasser
author_role author
author2 Kohn, Taylor P
Cinnioglu, Cengiz
Rubio, Carmen
Simon, Carlos
Ramasamy, Ranjith
Al-Asmar, Nasser
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Advanced paternal age
Advanced maternal age
Aneuploidy
In vitro fertilization
Egg donor
topic Advanced paternal age
Advanced maternal age
Aneuploidy
In vitro fertilization
Egg donor
description Purpose To study the impact of advanced paternal age on embryo aneuploidy. Methods This is a multicenter international retrospective case series of couples undergoing assisted reproduction via in vitro fertilization using donor eggs to control for maternal factors and preimplantation genetic testing for aneuploidy via next-generation sequencing at Igenomix reproductive testing centers. The main outcome measure was the prevalence of embryo aneuploidy in egg donor cycles. Semen analysis data was retrieved for a small subset of the male patients. Results Data from 1202 IVF/ICSI egg donor cycles using ejaculated sperm (total 6934 embryos) evaluated using PGT-A between January 2016 and April 2018 in a global population across all Igenomix centers were included. No significant association was identified between advancing paternal age and the prevalence of embryo aneuploidy overall and when analyzing for each chromosome. There was also no significant association between advancing paternal age and specific aneuploid conditions (monosomy, trisomy, partial deletion/duplication) for all chromosomes in the genome. Conclusions This is the largest study of its kind in an international patient population to evaluate the impact of advancing paternal age on embryo aneuploidy. We conclude there is no specific effect of paternal age on the prevalence of embryo aneuploidy in the context of embryo biopsies from egg donor cycles.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/3963
url https://incliva.portalinvestigacion.com/publicaciones/3963
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER/PLENUM PUBLISHERS
publisher.none.fl_str_mv SPRINGER/PLENUM PUBLISHERS
dc.source.none.fl_str_mv JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
ISSN: 10580468
ISSNe: 15737330
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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