Neural stem cells direct axon guidance via their radial fiber scaffold

Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction...

Descripción completa

Detalles Bibliográficos
Autores: Kaur, Navjot, Han, Wenqi, Li, Zhuo, Madrigal, M. Pilar, Shim, Sungbo, Pochareddy, Sirisha, Gulden, Forrest O., Li, Mingfeng, Xu, Xuming, Xing, Xiaojun, Takeo, Yutaka, Li, Zhen, Lu, Kangrong, Kawasawa, Yuka Imamura, Ballester-Lurbe, Begoña, Moreno-Bravo, Juan Antonio, Chédotal, Alain, Terrado, José, Pérez-Roger, Ignacio, Koleske, Anthony J., Sestan, Nenad
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/309598
Acceso en línea:http://hdl.handle.net/10261/309598
Access Level:acceso abierto
Palabra clave:Radial glia
Neural stem cells
Cerebral cortex
Medial ganglionic eminence
Axon guidance
Rho GTPase
Corticospinal tract
Anterior commissure
id ES_60dba33f7f73ea731bb4e0d7be08133f
oai_identifier_str oai:digital.csic.es:10261/309598
network_acronym_str ES
network_name_str España
repository_id_str
spelling Neural stem cells direct axon guidance via their radial fiber scaffoldKaur, NavjotHan, WenqiLi, ZhuoMadrigal, M. PilarShim, SungboPochareddy, SirishaGulden, Forrest O.Li, MingfengXu, XumingXing, XiaojunTakeo, YutakaLi, ZhenLu, KangrongKawasawa, Yuka ImamuraBallester-Lurbe, BegoñaMoreno-Bravo, Juan AntonioChédotal, AlainTerrado, JoséPérez-Roger, IgnacioKoleske, Anthony J.Sestan, NenadRadial gliaNeural stem cellsCerebral cortexMedial ganglionic eminenceAxon guidanceRho GTPaseCorticospinal tractAnterior commissureNeural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus. The maintenance of this scaffold, and consequently axon pathfinding, is dependent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neural stem cells within the ventricular zone of the medial ganglionic eminence. This role is independent of RND3 and ARHGAP35 expression in corticospinal neurons, where they regulate dendritic spine formation, axon elongation, and pontine midline crossing in a FEZF2-dependent manner. The prevalence of neural stem cell scaffolds and their expression of RND3 and ARHGAP35 suggests that these observations might be broadly relevant for axon guidance and neural circuit formation.This work was supported by Labex LifeSenses grants ANR-10-LABX-65 and ANR-11-IDEX-0004-02 to A.C.; MINECO SAF2013-49176-C2-1-R and Programa Santander-FUSP to I.P.-R. and J.T.; NIH grants R01 MH115939, NS105640, and NS089662 to A.J.K.; and NIH grants MH103339, MH106934, MH110926, and MH109904 to N.S. Additional support was provided by the Kavli Foundation and the Simons Foundation.Peer reviewedElsevierLabex MemoLifeAgence Nationale de la Recherche (France)Ministerio de Economía y Competitividad (España)Fundación Banco SantanderNational Institutes of Health (US)Kavli FoundationSimons Foundation202320232020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/309598reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//SAF2013-49176-C2-1-RNeuronhttps://doi.org/10.1016/j.neuron.2020.06.035Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3095982026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neural stem cells direct axon guidance via their radial fiber scaffold
title Neural stem cells direct axon guidance via their radial fiber scaffold
spellingShingle Neural stem cells direct axon guidance via their radial fiber scaffold
Kaur, Navjot
Radial glia
Neural stem cells
Cerebral cortex
Medial ganglionic eminence
Axon guidance
Rho GTPase
Corticospinal tract
Anterior commissure
title_short Neural stem cells direct axon guidance via their radial fiber scaffold
title_full Neural stem cells direct axon guidance via their radial fiber scaffold
title_fullStr Neural stem cells direct axon guidance via their radial fiber scaffold
title_full_unstemmed Neural stem cells direct axon guidance via their radial fiber scaffold
title_sort Neural stem cells direct axon guidance via their radial fiber scaffold
dc.creator.none.fl_str_mv Kaur, Navjot
Han, Wenqi
Li, Zhuo
Madrigal, M. Pilar
Shim, Sungbo
Pochareddy, Sirisha
Gulden, Forrest O.
Li, Mingfeng
Xu, Xuming
Xing, Xiaojun
Takeo, Yutaka
Li, Zhen
Lu, Kangrong
Kawasawa, Yuka Imamura
Ballester-Lurbe, Begoña
Moreno-Bravo, Juan Antonio
Chédotal, Alain
Terrado, José
Pérez-Roger, Ignacio
Koleske, Anthony J.
Sestan, Nenad
author Kaur, Navjot
author_facet Kaur, Navjot
Han, Wenqi
Li, Zhuo
Madrigal, M. Pilar
Shim, Sungbo
Pochareddy, Sirisha
Gulden, Forrest O.
Li, Mingfeng
Xu, Xuming
Xing, Xiaojun
Takeo, Yutaka
Li, Zhen
Lu, Kangrong
Kawasawa, Yuka Imamura
Ballester-Lurbe, Begoña
Moreno-Bravo, Juan Antonio
Chédotal, Alain
Terrado, José
Pérez-Roger, Ignacio
Koleske, Anthony J.
Sestan, Nenad
author_role author
author2 Han, Wenqi
Li, Zhuo
Madrigal, M. Pilar
Shim, Sungbo
Pochareddy, Sirisha
Gulden, Forrest O.
Li, Mingfeng
Xu, Xuming
Xing, Xiaojun
Takeo, Yutaka
Li, Zhen
Lu, Kangrong
Kawasawa, Yuka Imamura
Ballester-Lurbe, Begoña
Moreno-Bravo, Juan Antonio
Chédotal, Alain
Terrado, José
Pérez-Roger, Ignacio
Koleske, Anthony J.
Sestan, Nenad
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Labex MemoLife
Agence Nationale de la Recherche (France)
Ministerio de Economía y Competitividad (España)
Fundación Banco Santander
National Institutes of Health (US)
Kavli Foundation
Simons Foundation
dc.subject.none.fl_str_mv Radial glia
Neural stem cells
Cerebral cortex
Medial ganglionic eminence
Axon guidance
Rho GTPase
Corticospinal tract
Anterior commissure
topic Radial glia
Neural stem cells
Cerebral cortex
Medial ganglionic eminence
Axon guidance
Rho GTPase
Corticospinal tract
Anterior commissure
description Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus. The maintenance of this scaffold, and consequently axon pathfinding, is dependent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neural stem cells within the ventricular zone of the medial ganglionic eminence. This role is independent of RND3 and ARHGAP35 expression in corticospinal neurons, where they regulate dendritic spine formation, axon elongation, and pontine midline crossing in a FEZF2-dependent manner. The prevalence of neural stem cell scaffolds and their expression of RND3 and ARHGAP35 suggests that these observations might be broadly relevant for axon guidance and neural circuit formation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/309598
url http://hdl.handle.net/10261/309598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//SAF2013-49176-C2-1-R
Neuron
https://doi.org/10.1016/j.neuron.2020.06.035
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409338787889152
score 15.811543

Similares en LA Referencia