Neural stem cells direct axon guidance via their radial fiber scaffold

Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction...

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Detalles Bibliográficos
Autores: Kaur, Navjot, Han, Wenqi, Li, Zhuo, Madrigal, M. Pilar, Shim, Sungbo, Pochareddy, Sirisha, Gulden, Forrest O., Li, Mingfeng, Xu, Xuming, Xing, Xiaojun, Takeo, Yutaka, Li, Zhen, Lu, Kangrong, Kawasawa, Yuka Imamura, Ballester-Lurbe, Begoña, Moreno-Bravo, Juan Antonio, Chédotal, Alain, Terrado, José, Pérez-Roger, Ignacio, Koleske, Anthony J., Sestan, Nenad
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/309598
Acceso en línea:http://hdl.handle.net/10261/309598
Access Level:acceso abierto
Palabra clave:Radial glia
Neural stem cells
Cerebral cortex
Medial ganglionic eminence
Axon guidance
Rho GTPase
Corticospinal tract
Anterior commissure
Descripción
Sumario:Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at the junction between the striatum and globus pallidus. The maintenance of this scaffold, and consequently axon pathfinding, is dependent on the expression of an atypical RHO-GTPase, RND3/RHOE, together with its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neural stem cells within the ventricular zone of the medial ganglionic eminence. This role is independent of RND3 and ARHGAP35 expression in corticospinal neurons, where they regulate dendritic spine formation, axon elongation, and pontine midline crossing in a FEZF2-dependent manner. The prevalence of neural stem cell scaffolds and their expression of RND3 and ARHGAP35 suggests that these observations might be broadly relevant for axon guidance and neural circuit formation.

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