Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Marhuenda-Muñoz, María; Domínguez-López, Inés; Langohr, Klaus; Tresserra-Rimbau, Anna; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Zomeño, María Dolores; Martínez, J Alfredo; Alonso-Gómez, Angel M; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López-Miranda, José; Estruch, Ramón; Tinahones, Francisco J; Lapetra, José; Serra-Majem, Ll; Bueno-Cavanillas, Aurora; Tur, Josep A; Martín-Sánchez, Vicente; Pintó, Xavier; Delgado-Rodríguez, Miguel; Matía-Martín, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Fernández de la Puente Cervera, María; Barragán, Rocío; Fitó, Montse; Tojal-Sierra, Lucas; Gómez-Gracia, Enrique; Zazo, Juan Manuel; Morey, Marga; García-Ríos, Antonio; Casas, Rosa; Gómez-Pérez, Ana M; Santos-Lozano, José Manuel; Vázquez-Ruiz, Zenaida; Atzeni, Alessandro; Asensio, Eva M; Gili-Riu, M Mar; Bullon, Vanessa; Moreno-Rodriguez, Anai; Lecea, Oscar; Babio, Nancy; Peñas Lopez, Francesca; Gómez Melis, Guadalupe; Lamuela-Raventós, Rosa M

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids...

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Authors:	Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, María Dolores, Martínez, J Alfredo, Alonso-Gómez, Angel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Ll, Bueno-Cavanillas, Aurora, Tur, Josep A, Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montse, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M, Gili-Riu, M Mar, Bullon, Vanessa, Moreno-Rodriguez, Anai, Lecea, Oscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, Lamuela-Raventós, Rosa M
Format:	article
Publication Date:	2022
Country:	España
Institution:	Instituto de Salud Carlos III (ISCIII)
Repository:	Repisalud
Language:	English
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/18826
Online Access:	http://hdl.handle.net/20.500.12105/18826
Access Level:	Open access
Keyword:	Mediterranean diet PREDIMED-plus study cardiovascular health liquid chromatography mass spectrometry plasma carotenoids

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spelling	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular riskMarhuenda-Muñoz, MaríaDomínguez-López, InésLangohr, KlausTresserra-Rimbau, AnnaMartínez González, Miguel ÁngelSalas-Salvadó, JordiCorella, DoloresZomeño, María DoloresMartínez, J AlfredoAlonso-Gómez, Angel MWärnberg, JuliaVioque, JesúsRomaguera, DoraLópez-Miranda, JoséEstruch, RamónTinahones, Francisco JLapetra, JoséSerra-Majem, LlBueno-Cavanillas, AuroraTur, Josep AMartín-Sánchez, VicentePintó, XavierDelgado-Rodríguez, MiguelMatía-Martín, PilarVidal, JosepVázquez, ClotildeDaimiel, LidiaRos, EmilioToledo, EstefaníaFernández de la Puente Cervera, MaríaBarragán, RocíoFitó, MontseTojal-Sierra, LucasGómez-Gracia, EnriqueZazo, Juan ManuelMorey, MargaGarcía-Ríos, AntonioCasas, RosaGómez-Pérez, Ana MSantos-Lozano, José ManuelVázquez-Ruiz, ZenaidaAtzeni, AlessandroAsensio, Eva MGili-Riu, M MarBullon, VanessaMoreno-Rodriguez, AnaiLecea, OscarBabio, NancyPeñas Lopez, FrancescaGómez Melis, GuadalupeLamuela-Raventós, Rosa MMediterranean dietPREDIMED-plus studycardiovascular healthliquid chromatographymass spectrometryplasma carotenoidsCarotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001].20242024-02-2720222022-09-2920222022-09-29research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18826reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/188262026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
title	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
spellingShingle	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk Marhuenda-Muñoz, María Mediterranean diet PREDIMED-plus study cardiovascular health liquid chromatography mass spectrometry plasma carotenoids
title_short	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
title_full	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
title_fullStr	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
title_full_unstemmed	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
title_sort	Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk
dc.creator.none.fl_str_mv	Marhuenda-Muñoz, María Domínguez-López, Inés Langohr, Klaus Tresserra-Rimbau, Anna Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Zomeño, María Dolores Martínez, J Alfredo Alonso-Gómez, Angel M Wärnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramón Tinahones, Francisco J Lapetra, José Serra-Majem, Ll Bueno-Cavanillas, Aurora Tur, Josep A Martín-Sánchez, Vicente Pintó, Xavier Delgado-Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Fernández de la Puente Cervera, María Barragán, Rocío Fitó, Montse Tojal-Sierra, Lucas Gómez-Gracia, Enrique Zazo, Juan Manuel Morey, Marga García-Ríos, Antonio Casas, Rosa Gómez-Pérez, Ana M Santos-Lozano, José Manuel Vázquez-Ruiz, Zenaida Atzeni, Alessandro Asensio, Eva M Gili-Riu, M Mar Bullon, Vanessa Moreno-Rodriguez, Anai Lecea, Oscar Babio, Nancy Peñas Lopez, Francesca Gómez Melis, Guadalupe Lamuela-Raventós, Rosa M
author	Marhuenda-Muñoz, María
author_facet	Marhuenda-Muñoz, María Domínguez-López, Inés Langohr, Klaus Tresserra-Rimbau, Anna Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Zomeño, María Dolores Martínez, J Alfredo Alonso-Gómez, Angel M Wärnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramón Tinahones, Francisco J Lapetra, José Serra-Majem, Ll Bueno-Cavanillas, Aurora Tur, Josep A Martín-Sánchez, Vicente Pintó, Xavier Delgado-Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Fernández de la Puente Cervera, María Barragán, Rocío Fitó, Montse Tojal-Sierra, Lucas Gómez-Gracia, Enrique Zazo, Juan Manuel Morey, Marga García-Ríos, Antonio Casas, Rosa Gómez-Pérez, Ana M Santos-Lozano, José Manuel Vázquez-Ruiz, Zenaida Atzeni, Alessandro Asensio, Eva M Gili-Riu, M Mar Bullon, Vanessa Moreno-Rodriguez, Anai Lecea, Oscar Babio, Nancy Peñas Lopez, Francesca Gómez Melis, Guadalupe Lamuela-Raventós, Rosa M
author_role	author
author2	Domínguez-López, Inés Langohr, Klaus Tresserra-Rimbau, Anna Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Zomeño, María Dolores Martínez, J Alfredo Alonso-Gómez, Angel M Wärnberg, Julia Vioque, Jesús Romaguera, Dora López-Miranda, José Estruch, Ramón Tinahones, Francisco J Lapetra, José Serra-Majem, Ll Bueno-Cavanillas, Aurora Tur, Josep A Martín-Sánchez, Vicente Pintó, Xavier Delgado-Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Fernández de la Puente Cervera, María Barragán, Rocío Fitó, Montse Tojal-Sierra, Lucas Gómez-Gracia, Enrique Zazo, Juan Manuel Morey, Marga García-Ríos, Antonio Casas, Rosa Gómez-Pérez, Ana M Santos-Lozano, José Manuel Vázquez-Ruiz, Zenaida Atzeni, Alessandro Asensio, Eva M Gili-Riu, M Mar Bullon, Vanessa Moreno-Rodriguez, Anai Lecea, Oscar Babio, Nancy Peñas Lopez, Francesca Gómez Melis, Guadalupe Lamuela-Raventós, Rosa M
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Mediterranean diet PREDIMED-plus study cardiovascular health liquid chromatography mass spectrometry plasma carotenoids
topic	Mediterranean diet PREDIMED-plus study cardiovascular health liquid chromatography mass spectrometry plasma carotenoids
description	Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001].
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-09-29 2022 2022-09-29 2024 2024-02-27
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/18826
url	http://hdl.handle.net/20.500.12105/18826
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869409296066805760
score	15.812429

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

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