Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder

Background and Objectives: This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper will discuss the evidence of their efficacy r...

Descripción completa

Detalles Bibliográficos
Autores: Grunze, Anna, Amann, Benedikt L.|||0000-0002-4407-1519, Grunze, Heinz|||0000-0003-4712-8979
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255545
Acceso en línea:https://ddd.uab.cat/record/255545
https://dx.doi.org/urn:doi:10.3390/medicina57050433
Access Level:acceso abierto
Palabra clave:Bipolar disorder
Carbamazepine
Depression
Eslicarbazepine
Maintenance
Mania
Oxcarbazepine
Predominant polarity
id ES_5ff6c219574a6c1a63f35fee3e6dc6c2
oai_identifier_str oai:ddd.uab.cat:255545
network_acronym_str ES
network_name_str España
repository_id_str
spelling Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar DisorderGrunze, AnnaAmann, Benedikt L.|||0000-0002-4407-1519Grunze, Heinz|||0000-0003-4712-8979Bipolar disorderCarbamazepineDepressionEslicarbazepineMaintenanceManiaOxcarbazepinePredominant polarityBackground and Objectives: This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper will discuss the evidence of their efficacy relative to the polarity of relapse from controlled acute and maintenance/relapse prevention studies in bipolar patients. Materials and Methods: A Medline search was conducted for controlled acute and maintenance studies with carbamazepine, oxcarbazepine, and eslicarbazepine in bipolar disorder. In addition, abstracts reporting on controlled studies with these medications from key conferences were taken into consideration. Results: Information was extracted from 84 articles on the acute and prophylactic efficacy of the medications under consideration. They all appear to have stronger efficacy in treating acute mania than depression, which also translates to better protection against manic than depressive relapses for carbamazepine. Still, there is a paucity of controlled acute studies on bipolar depression for all and, with the exception of carbamazepine, a lack of long-term monotherapy maintenance data. For eslicarbazepine, the efficacy in bipolar disorder remains largely unknown. Especially with carbamazepine, tolerability issues and drug-drug interactions need to be kept in mind. Conclusions: Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/255545https://dx.doi.org/urn:doi:10.3390/medicina57050433reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI/15/02242Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2555452026-06-06T12:50:31Z
dc.title.none.fl_str_mv Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
title Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
spellingShingle Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
Grunze, Anna
Bipolar disorder
Carbamazepine
Depression
Eslicarbazepine
Maintenance
Mania
Oxcarbazepine
Predominant polarity
title_short Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
title_full Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
title_fullStr Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
title_full_unstemmed Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
title_sort Efficacy of Carbamazepine and Its Derivatives in the Treatment of Bipolar Disorder
dc.creator.none.fl_str_mv Grunze, Anna
Amann, Benedikt L.|||0000-0002-4407-1519
Grunze, Heinz|||0000-0003-4712-8979
author Grunze, Anna
author_facet Grunze, Anna
Amann, Benedikt L.|||0000-0002-4407-1519
Grunze, Heinz|||0000-0003-4712-8979
author_role author
author2 Amann, Benedikt L.|||0000-0002-4407-1519
Grunze, Heinz|||0000-0003-4712-8979
author2_role author
author
dc.subject.none.fl_str_mv Bipolar disorder
Carbamazepine
Depression
Eslicarbazepine
Maintenance
Mania
Oxcarbazepine
Predominant polarity
topic Bipolar disorder
Carbamazepine
Depression
Eslicarbazepine
Maintenance
Mania
Oxcarbazepine
Predominant polarity
description Background and Objectives: This review is dedicated to the use of carbamazepine and its derivatives oxcarbazepine and eslicarbazepine in bipolar disorder and their relative strengths in treating and preventing new depressive or manic episodes. This paper will discuss the evidence of their efficacy relative to the polarity of relapse from controlled acute and maintenance/relapse prevention studies in bipolar patients. Materials and Methods: A Medline search was conducted for controlled acute and maintenance studies with carbamazepine, oxcarbazepine, and eslicarbazepine in bipolar disorder. In addition, abstracts reporting on controlled studies with these medications from key conferences were taken into consideration. Results: Information was extracted from 84 articles on the acute and prophylactic efficacy of the medications under consideration. They all appear to have stronger efficacy in treating acute mania than depression, which also translates to better protection against manic than depressive relapses for carbamazepine. Still, there is a paucity of controlled acute studies on bipolar depression for all and, with the exception of carbamazepine, a lack of long-term monotherapy maintenance data. For eslicarbazepine, the efficacy in bipolar disorder remains largely unknown. Especially with carbamazepine, tolerability issues and drug-drug interactions need to be kept in mind. Conclusions: Two of the medications discussed in this review, carbamazepine and oxcarbazepine, match Class A criteria according to the criteria proposed by Ketter and Calabrese, meaning acute antimanic efficacy, prevention of manic relapses, and not causing or worsening depression.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/255545
https://dx.doi.org/urn:doi:10.3390/medicina57050433
url https://ddd.uab.cat/record/255545
https://dx.doi.org/urn:doi:10.3390/medicina57050433
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI/15/02242
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409257446703104
score 15.301603

Similares en LA Referencia