Importance of genetics in acute myeloid leukemia

Acute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML...

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Autores: Pippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44f, Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/63915
Acceso en línea:https://hdl.handle.net/10171/63915
Access Level:acceso abierto
Palabra clave:Acute myeloid leukemia
Genetic marker
Mutation
Whole-genome sequencing
Prognosis
Leucemia mieloide aguda
Marcador genético
Mutación
Secuenciación masiva
Pronóstico
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spelling Importance of genetics in acute myeloid leukemiaPapel de la genética en la leucemia mieloide agudaPippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44fOdero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251Acute myeloid leukemiaGenetic markerMutationWhole-genome sequencingPrognosisLeucemia mieloide agudaMarcador genéticoMutaciónSecuenciación masivaPronósticoAcute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML, most patients will die from relapsed disease. Whole-genome studies have identified novel recurrent gene mutations with prognostic impact in AML; furthermore, it is likely that in the near future genome-wide sequencing will become a routine for newly diagnosed patients with AML. Therefore, future clinical trials should aim to identify genetically defined high-risk patients, and further research is necessary to identify effective agents and develop new individualized therapeutic strategies for the treatment of this deadly disease.Gobierno de NavarraDadun. Depósito Académico Digital Universidad de Navarra20222022-08-1220142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63915reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/639152026-06-21T12:47:57Z
dc.title.none.fl_str_mv Importance of genetics in acute myeloid leukemia
Papel de la genética en la leucemia mieloide aguda
title Importance of genetics in acute myeloid leukemia
spellingShingle Importance of genetics in acute myeloid leukemia
Pippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44f
Acute myeloid leukemia
Genetic marker
Mutation
Whole-genome sequencing
Prognosis
Leucemia mieloide aguda
Marcador genético
Mutación
Secuenciación masiva
Pronóstico
title_short Importance of genetics in acute myeloid leukemia
title_full Importance of genetics in acute myeloid leukemia
title_fullStr Importance of genetics in acute myeloid leukemia
title_full_unstemmed Importance of genetics in acute myeloid leukemia
title_sort Importance of genetics in acute myeloid leukemia
dc.creator.none.fl_str_mv Pippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44f
Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
author Pippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44f
author_facet Pippa, R. (Raffaella)|||/items/cead403c-7be6-42cc-a281-02ea103aa44f
Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
author_role author
author2 Odero, M.D. (Maria Dolores)|||/items/6679bbec-f7dd-480c-a44c-44d7c8493251
author2_role author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Acute myeloid leukemia
Genetic marker
Mutation
Whole-genome sequencing
Prognosis
Leucemia mieloide aguda
Marcador genético
Mutación
Secuenciación masiva
Pronóstico
topic Acute myeloid leukemia
Genetic marker
Mutation
Whole-genome sequencing
Prognosis
Leucemia mieloide aguda
Marcador genético
Mutación
Secuenciación masiva
Pronóstico
description Acute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML, most patients will die from relapsed disease. Whole-genome studies have identified novel recurrent gene mutations with prognostic impact in AML; furthermore, it is likely that in the near future genome-wide sequencing will become a routine for newly diagnosed patients with AML. Therefore, future clinical trials should aim to identify genetically defined high-risk patients, and further research is necessary to identify effective agents and develop new individualized therapeutic strategies for the treatment of this deadly disease.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
2022
2022-08-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/63915
url https://hdl.handle.net/10171/63915
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Gobierno de Navarra
publisher.none.fl_str_mv Gobierno de Navarra
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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