Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: un...

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Authors: Ainsua-Enrich, Erola, Pedreño-Lopez, Núria, Bracke, Carmen, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Pradenas, Edwards, Trinité, Benjamin, Marfil, Silvia, Miranda, Cristina, González, Sandra, Toledo, Ruth, Font, Marta, Benet, Susana, Escribà, Tuixent, Jimenez-Moyano, Esther, Peña, Ruth, Cedeño, Samandhy, Prado, Julia G., Mothe, Beatriz, Brander, Christian, Izquierdo-Useros, Nuria, Serra Gironella, Joan, Segalés, Joaquim, Massanella, Marta, Benitez, Rosa María, Romero, Alba, Molina-Morant, Daniel, Blanco, Julià, Clotet, Bonaventura, Mateu, Lourdes, Pedro-Botet, María Luisa, Carrillo, Jorge
Format: article
Publication Date:2022
Country:España
Institution:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
Repository:IRTA Pubpro. Open Digital Archive
OAI Identifier:oai:repositori.irta.cat:20.500.12327/1985
Online Access:http://hdl.handle.net/20.500.12327/1985
https://doi.org/10.1016/j.isci.2022.105455
Access Level:Open access
Keyword:619
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network_acronym_str ES
network_name_str España
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spelling Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individualsAinsua-Enrich, ErolaPedreño-Lopez, NúriaBracke, CarmenÁvila-Nieto, CarlosRodríguez de la Concepción, María LuisaPradenas, EdwardsTrinité, BenjaminMarfil, SilviaMiranda, CristinaGonzález, SandraToledo, RuthFont, MartaBenet, SusanaEscribà, TuixentJimenez-Moyano, EstherPeña, RuthCedeño, SamandhyPrado, Julia G.Mothe, BeatrizBrander, ChristianIzquierdo-Useros, NuriaSerra Gironella, JoanSegalés, JoaquimMassanella, MartaBenitez, Rosa MaríaRomero, AlbaMolina-Morant, DanielBlanco, JuliàClotet, BonaventuraMateu, LourdesPedro-Botet, María LuisaCarrillo, Jorge619Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: unclassified primary antibody-deficiency (unPAD, n = 9), common variable immunodeficiency (CVID, n = 12), combined immunodeficiency (CID, n = 1), and thymoma with immunodeficiency (TID, n = 1). unPAD patients and healthy controls (HCs, n = 10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Of interest, these PAD groups showed lower levels of Spike-specific IFN-γ-producing cells. CVID individuals also presented diminished CD8+T cells. CID and TID patients developed cellular but not humoral responses. Although the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies.info:eu-repo/semantics/publishedVersionCell PressProducció AnimalSanitat Animal202220222022info:eu-repo/semantics/article19application/pdfhttp://hdl.handle.net/20.500.12327/1985https://doi.org/10.1016/j.isci.2022.105455reponame:IRTA Pubpro. Open Digital Archiveinstname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)InglésiScienceISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI17-01518/Desarrollo de una plataforma de vacunas contra el VIH basada en partículas similares a virus (VLP) envueltas y de alta densidad antigénica/ISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI18-01332/ES/Identificación, aislamiento y caracterización de anticuerpos que interfieren con la acción de los anticuerpos neutralizantes en personas infectadas por el virus de la inmunodeficiencia humana/MC/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-119710RB-I00/ES/La cascada epigenética de infecciones virales neurotrópicas/Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.irta.cat:20.500.12327/19852026-06-16T08:51:17Z
dc.title.none.fl_str_mv Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
title Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
spellingShingle Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
Ainsua-Enrich, Erola
619
title_short Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
title_full Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
title_fullStr Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
title_full_unstemmed Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
title_sort Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
dc.creator.none.fl_str_mv Ainsua-Enrich, Erola
Pedreño-Lopez, Núria
Bracke, Carmen
Ávila-Nieto, Carlos
Rodríguez de la Concepción, María Luisa
Pradenas, Edwards
Trinité, Benjamin
Marfil, Silvia
Miranda, Cristina
González, Sandra
Toledo, Ruth
Font, Marta
Benet, Susana
Escribà, Tuixent
Jimenez-Moyano, Esther
Peña, Ruth
Cedeño, Samandhy
Prado, Julia G.
Mothe, Beatriz
Brander, Christian
Izquierdo-Useros, Nuria
Serra Gironella, Joan
Segalés, Joaquim
Massanella, Marta
Benitez, Rosa María
Romero, Alba
Molina-Morant, Daniel
Blanco, Julià
Clotet, Bonaventura
Mateu, Lourdes
Pedro-Botet, María Luisa
Carrillo, Jorge
author Ainsua-Enrich, Erola
author_facet Ainsua-Enrich, Erola
Pedreño-Lopez, Núria
Bracke, Carmen
Ávila-Nieto, Carlos
Rodríguez de la Concepción, María Luisa
Pradenas, Edwards
Trinité, Benjamin
Marfil, Silvia
Miranda, Cristina
González, Sandra
Toledo, Ruth
Font, Marta
Benet, Susana
Escribà, Tuixent
Jimenez-Moyano, Esther
Peña, Ruth
Cedeño, Samandhy
Prado, Julia G.
Mothe, Beatriz
Brander, Christian
Izquierdo-Useros, Nuria
Serra Gironella, Joan
Segalés, Joaquim
Massanella, Marta
Benitez, Rosa María
Romero, Alba
Molina-Morant, Daniel
Blanco, Julià
Clotet, Bonaventura
Mateu, Lourdes
Pedro-Botet, María Luisa
Carrillo, Jorge
author_role author
author2 Pedreño-Lopez, Núria
Bracke, Carmen
Ávila-Nieto, Carlos
Rodríguez de la Concepción, María Luisa
Pradenas, Edwards
Trinité, Benjamin
Marfil, Silvia
Miranda, Cristina
González, Sandra
Toledo, Ruth
Font, Marta
Benet, Susana
Escribà, Tuixent
Jimenez-Moyano, Esther
Peña, Ruth
Cedeño, Samandhy
Prado, Julia G.
Mothe, Beatriz
Brander, Christian
Izquierdo-Useros, Nuria
Serra Gironella, Joan
Segalés, Joaquim
Massanella, Marta
Benitez, Rosa María
Romero, Alba
Molina-Morant, Daniel
Blanco, Julià
Clotet, Bonaventura
Mateu, Lourdes
Pedro-Botet, María Luisa
Carrillo, Jorge
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Sanitat Animal
dc.subject.none.fl_str_mv 619
topic 619
description Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: unclassified primary antibody-deficiency (unPAD, n = 9), common variable immunodeficiency (CVID, n = 12), combined immunodeficiency (CID, n = 1), and thymoma with immunodeficiency (TID, n = 1). unPAD patients and healthy controls (HCs, n = 10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Of interest, these PAD groups showed lower levels of Spike-specific IFN-γ-producing cells. CVID individuals also presented diminished CD8+T cells. CID and TID patients developed cellular but not humoral responses. Although the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/1985
https://doi.org/10.1016/j.isci.2022.105455
url http://hdl.handle.net/20.500.12327/1985
https://doi.org/10.1016/j.isci.2022.105455
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv iScience
ISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI17-01518/Desarrollo de una plataforma de vacunas contra el VIH basada en partículas similares a virus (VLP) envueltas y de alta densidad antigénica/
ISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI18-01332/ES/Identificación, aislamiento y caracterización de anticuerpos que interfieren con la acción de los anticuerpos neutralizantes en personas infectadas por el virus de la inmunodeficiencia humana/
MC/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-119710RB-I00/ES/La cascada epigenética de infecciones virales neurotrópicas/
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 19
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:IRTA Pubpro. Open Digital Archive
instname:Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
instname_str Institut de Recerca i Tecnologia Agroalimentàries (IRTA)
reponame_str IRTA Pubpro. Open Digital Archive
collection IRTA Pubpro. Open Digital Archive
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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