Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: un...

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Autores: Ainsua-Enrich, Erola|||0000-0001-7901-5798, Pedreño López, Núria|||0000-0001-6927-2301, Bracke Manzanares, Carmen|||0000-0002-0306-8321, Avila-Nieto, Carlos, Rodriguez de la Concepción, Maria Luisa|||0000-0002-6944-3462, Pradenas, Edwards|||0000-0001-5162-8920, Trinité, Benjamin|||0000-0003-3809-042X, Marfil, Sílvia|||0000-0003-0139-5000, Miranda, Cristina, González, Sandra, Toledo, Ruth, Font, Marta, Benet, Susana|||0000-0002-2219-8826, Escribà, Tuixent|||0000-0001-9467-7802, Jiménez-Moyano, Esther|||0000-0002-0005-6544, Peña, Ruth, Cedeño, Samandhy|||0000-0001-8312-0208, Prado, Julia G.|||0000-0002-5439-4645, Mothe, Beatriz|||0000-0001-9975-407X, Brander, Christian|||0000-0002-0548-5778, Izquierdo Useros, Nuria|||0000-0002-1039-1821, Vergara-Alert, Júlia|||0000-0001-7484-444X, Segalés Coma, Joaquim|||0000-0002-1539-7261, Massanella, Marta|||0000-0002-3326-151X, Benítez Díaz, Rosa María|||0000-0001-6972-6094, Romero, Alba, Molina-Morant, Daniel|||0000-0002-4102-1065, Blanco, Julià|||0000-0002-2225-0217, Clotet Sala, Bonaventura|||0000-0003-3232-4598, Mateu, Lourdes|||0000-0001-7223-7611, Pedro Botet, Maria Luisa|||0000-0001-7252-3191, Carrillo, Jorge|||0000-0003-0221-5948
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:268235
Acceso en línea:https://ddd.uab.cat/record/268235
https://dx.doi.org/urn:doi:10.1016/j.isci.2022.105455
Access Level:acceso abierto
Palabra clave:Immune response
Immunology
Virology
Descripción
Sumario:Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: unclassified primary antibody-deficiency (unPAD, n=9), common variable immunodeficiency (CVID, n=12), combined immunodeficiency (CID, n=1), and thymoma with immunodeficiency (TID, n=1). unPAD patients and healthy controls (HCs, n=10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Interestingly, these PAD groups showed lower levels of Spike-specific IFN-γ-producing cells. CVID individuals also presented diminished CD8+ T cells. CID and TID patients developed cellular but not humoral responses. While the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies.

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