Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin

Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM....

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Autores: Corbacho-Alonso, Nerea, Rodríguez-Sánchez, Elena, Sastre-Oliva, Tamara, Mercado-García, Elisa, Perales-Sánchez, Ines, Juarez-Alia, Cristina, López-Almodovar, Luis, Padial, Luis, Tejerina Sánchez, María Teresa, Mourino-Alvarez, Laura, Ruiz-Hurtado, Gema, Barderas, María
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/109987
Acceso en línea:https://hdl.handle.net/20.500.14352/109987
Access Level:acceso abierto
Palabra clave:615
calcific aortic stenosis
Diabetes mellitus
Oxidative stress
Antioxidant defense
Metformin
Farmacología (Medicina)
3209 Farmacología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/109987
network_acronym_str ES
network_name_str España
repository_id_str
spelling Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metforminCorbacho-Alonso, NereaRodríguez-Sánchez, ElenaSastre-Oliva, TamaraMercado-García, ElisaPerales-Sánchez, InesJuarez-Alia, CristinaLópez-Almodovar, LuisPadial, LuisTejerina Sánchez, María TeresaMourino-Alvarez, LauraRuiz-Hurtado, GemaBarderas, María615calcific aortic stenosisDiabetes mellitusOxidative stressAntioxidant defenseMetforminFarmacología (Medicina)3209 FarmacologíaCalcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine.MDPIUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/109987reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1099872026-06-02T12:44:21Z
dc.title.none.fl_str_mv Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
title Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
spellingShingle Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
Corbacho-Alonso, Nerea
615
calcific aortic stenosis
Diabetes mellitus
Oxidative stress
Antioxidant defense
Metformin
Farmacología (Medicina)
3209 Farmacología
title_short Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
title_full Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
title_fullStr Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
title_full_unstemmed Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
title_sort Global oxidative status is linked to calcific aortic stenosis: the differences due to diabetes mellitus and the effects of metformin
dc.creator.none.fl_str_mv Corbacho-Alonso, Nerea
Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis
Padial, Luis
Tejerina Sánchez, María Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María
author Corbacho-Alonso, Nerea
author_facet Corbacho-Alonso, Nerea
Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis
Padial, Luis
Tejerina Sánchez, María Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María
author_role author
author2 Rodríguez-Sánchez, Elena
Sastre-Oliva, Tamara
Mercado-García, Elisa
Perales-Sánchez, Ines
Juarez-Alia, Cristina
López-Almodovar, Luis
Padial, Luis
Tejerina Sánchez, María Teresa
Mourino-Alvarez, Laura
Ruiz-Hurtado, Gema
Barderas, María
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615
calcific aortic stenosis
Diabetes mellitus
Oxidative stress
Antioxidant defense
Metformin
Farmacología (Medicina)
3209 Farmacología
topic 615
calcific aortic stenosis
Diabetes mellitus
Oxidative stress
Antioxidant defense
Metformin
Farmacología (Medicina)
3209 Farmacología
description Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/109987
url https://hdl.handle.net/20.500.14352/109987
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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