Albumin redox modifications promote cell calcification reflecting the impact of oxidative status on aortic valve disease and atherosclerosis

Calcific aortic valve disease (CAVD) and coronary artery disease (CAD) are related cardiovascular diseases in which common mechanisms lead to tissue calcification. Oxidative stress plays a key role in these diseases and there is also evidence that the redox state of serum albumin exerts a significan...

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Detalles Bibliográficos
Autores: Sastre Oliva, Tamara, Corbacho Alonso, Nerea, Rodríguez Sánchez, Elena, Mercado García, Elisa, Perales Sánchez, Inés, Hernández Fernández, Germán, Juárez Alia, Cristina, Tejerina Sánchez, María Teresa, López Almodóvar, Luis F., Padial, Luis R, Sánchez, Pedro L., Martín Núñez, Ernesto, López Andrés, Natalia, Ruiz- Hurtado, Gema, Mourino Álvarez, Laura, Barderas, María G.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/105950
Acceso en línea:https://hdl.handle.net/20.500.14352/105950
Access Level:acceso abierto
Palabra clave:615
Aortic stenosis
Interstitial cells
Calcification
Artery
Aortic valve
Oxidative stress
Multimarker score
Farmacología (Medicina)
3209 Farmacología
Descripción
Sumario:Calcific aortic valve disease (CAVD) and coronary artery disease (CAD) are related cardiovascular diseases in which common mechanisms lead to tissue calcification. Oxidative stress plays a key role in these diseases and there is also evidence that the redox state of serum albumin exerts a significant influence on these conditions. To further explore this issue, we used multimarker scores (OxyScore and AntioxyScore) to assess the global oxidative status in patients with CAVD, with and without CAD, also evaluating their plasma thiol levels. In addition, valvular interstitial cells were treated with reduced, oxidized, and native albumin to study how this protein and its modifications affect cell calcification. The differences we found suggest that oxidative status is distinct in CAVD and CAD, with differences in redox markers and thiol levels. Importantly, the in vitro interstitial cell model revealed that modified albumin affects cell calcification, accelerating this process. Hence, we show here the importance of the redox system in the development of CAVD, emphasizing the relevance of multimarker scores, while also offering evidence of how the redox state of albumin influences vascular calcification. These data highlight the relevance of understanding the overall redox processes involved in these diseases, opening the door to new studies on antioxidants as potential therapies for these patients.

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