Upstream deregulation of calcium signaling in Parkinson’s disease

Parkinson’s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handlin...

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Detalhes bibliográficos
Autores: Rivero-Ríos, Pilar, Gómez-Suaga, P., Fdez, Elena, Hilfiker, Sabine
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/112067
Acesso em linha:http://hdl.handle.net/10261/112067
Access Level:acceso abierto
Palavra-chave:Parkinson’s disease
Dopamine
Calcium
Mitochondria
endoplasmic reticulum
Lysosomes
Golgi
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spelling Upstream deregulation of calcium signaling in Parkinson’s diseaseRivero-Ríos, PilarGómez-Suaga, P.Fdez, ElenaHilfiker, SabineParkinson’s diseaseDopamineCalciumMitochondriaendoplasmic reticulumLysosomesGolgiParkinson’s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.Spanish Ministry of Economy and Competitiveness (BFU2011-29899), the Junta de Andalucia (grant number CTS 6816), and the Michael J. Fox FoundationPeer reviewedFrontiers MediaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/112067reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://journal.frontiersin.org/article/10.3389/fnmol.2014.00053/full#h11Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1120672026-05-22T06:33:51Z
dc.title.none.fl_str_mv Upstream deregulation of calcium signaling in Parkinson’s disease
title Upstream deregulation of calcium signaling in Parkinson’s disease
spellingShingle Upstream deregulation of calcium signaling in Parkinson’s disease
Rivero-Ríos, Pilar
Parkinson’s disease
Dopamine
Calcium
Mitochondria
endoplasmic reticulum
Lysosomes
Golgi
title_short Upstream deregulation of calcium signaling in Parkinson’s disease
title_full Upstream deregulation of calcium signaling in Parkinson’s disease
title_fullStr Upstream deregulation of calcium signaling in Parkinson’s disease
title_full_unstemmed Upstream deregulation of calcium signaling in Parkinson’s disease
title_sort Upstream deregulation of calcium signaling in Parkinson’s disease
dc.creator.none.fl_str_mv Rivero-Ríos, Pilar
Gómez-Suaga, P.
Fdez, Elena
Hilfiker, Sabine
author Rivero-Ríos, Pilar
author_facet Rivero-Ríos, Pilar
Gómez-Suaga, P.
Fdez, Elena
Hilfiker, Sabine
author_role author
author2 Gómez-Suaga, P.
Fdez, Elena
Hilfiker, Sabine
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Parkinson’s disease
Dopamine
Calcium
Mitochondria
endoplasmic reticulum
Lysosomes
Golgi
topic Parkinson’s disease
Dopamine
Calcium
Mitochondria
endoplasmic reticulum
Lysosomes
Golgi
description Parkinson’s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental, and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.
publishDate 2014
dc.date.none.fl_str_mv 2014
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/112067
url http://hdl.handle.net/10261/112067
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://journal.frontiersin.org/article/10.3389/fnmol.2014.00053/full#h11
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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