Stay in touch with the endoplasmic reticulum

The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it engages a variety of organelles by establishing membrane contact sites (MCSs). These contacts regulate organelle pos...

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Detalhes bibliográficos
Autores: Sun, Sha, Zhao, Gan, Jia, Mingkang, Jiang, Qing, Li, Shulin, Wang, Haibin, Li, Wenjing, Wang, Yunyun, Bian, Xin, Zhao, Yan G., Huang, Xun, Yang, Ge, Cai, Huaqing, Pastor-Pareja, José Carlos, Ge, Liang, Zhang, Chuanmao, Hu, Junjie
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/359298
Acesso em linha:http://hdl.handle.net/10261/359298
Access Level:Acceso aberto
Palavra-chave:Golgi apparatus
Autophagosome
Endoplasmic reticulum
Endosome
Lipid droplets
Lysosome
Membrane contact site
Mitochondria
Nuclear envelope
Plasma membrane
Descrição
Resumo:The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it engages a variety of organelles by establishing membrane contact sites (MCSs). These contacts regulate organelle positioning and remodeling, including fusion and fission, facilitate precise lipid exchange, and couple vital signaling events. Here, we systematically review recent advances and converging themes on ER-involved organellar contact. The molecular basis, cellular influence, and potential physiological functions for ER/nuclear envelope contacts with mitochondria, Golgi, endosomes, lysosomes, lipid droplets, autophagosomes, and plasma membrane are summarized.

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