Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions...

Descripción completa

Detalles Bibliográficos
Autores: Alique Aguilar, Matilde|||0000-0002-7912-1133, Sánchez López, Elsa, Bodega Magro, Guillermo|||0000-0003-1469-3242, Giannarelli, Chiara, Carracedo Añón, Julia María, Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/51267
Acceso en línea:http://hdl.handle.net/10017/51267
https://dx.doi.org/10.3390/cells9010195
Access Level:acceso abierto
Palabra clave:Hypoxia-inducible factor-1alfa (HIF1alfa)
Vascular aging
Senescent cells
Endothelial cells
Vascular smooth muscle cells
Atherosclerosis
Extracellular vesicles
Medicina
Medicine
id ES_5ded57f487e9b02c5d43c2f3dc69aced
oai_identifier_str oai:ebuah.uah.es:10017/51267
network_acronym_str ES
network_name_str España
repository_id_str
spelling Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular AgingAlique Aguilar, Matilde|||0000-0002-7912-1133Sánchez López, ElsaBodega Magro, Guillermo|||0000-0003-1469-3242Giannarelli, ChiaraCarracedo Añón, Julia MaríaRamírez Chamond, Manuel Rafael|||0000-0003-4598-339XHypoxia-inducible factor-1alfa (HIF1alfa)Vascular agingSenescent cellsEndothelial cellsVascular smooth muscle cellsAtherosclerosisExtracellular vesiclesMedicinaMedicineAging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and sti ness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1 as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1 in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.Instituto de Salud Carlos IIISociedad Española de NefrologíaUniversidad de AlcaláGrupo SantanderUniversity of California San Diego20202020-01-20journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/51267https://dx.doi.org/10.3390/cells9010195reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengISCIII PI19%2F00240 ESISCIII PI17%2F01029 ESGrupo Santander%2FUCM PR41%2F17-20964 Not availableUAH Not available GP-2018-4UAH Not available CGC2018%2FBIO-012UCSD Not available P30AR073761open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/512672026-06-18T11:13:07Z
dc.title.none.fl_str_mv Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
title Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
spellingShingle Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
Alique Aguilar, Matilde|||0000-0002-7912-1133
Hypoxia-inducible factor-1alfa (HIF1alfa)
Vascular aging
Senescent cells
Endothelial cells
Vascular smooth muscle cells
Atherosclerosis
Extracellular vesicles
Medicina
Medicine
title_short Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
title_full Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
title_fullStr Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
title_full_unstemmed Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
title_sort Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
dc.creator.none.fl_str_mv Alique Aguilar, Matilde|||0000-0002-7912-1133
Sánchez López, Elsa
Bodega Magro, Guillermo|||0000-0003-1469-3242
Giannarelli, Chiara
Carracedo Añón, Julia María
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author Alique Aguilar, Matilde|||0000-0002-7912-1133
author_facet Alique Aguilar, Matilde|||0000-0002-7912-1133
Sánchez López, Elsa
Bodega Magro, Guillermo|||0000-0003-1469-3242
Giannarelli, Chiara
Carracedo Añón, Julia María
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author_role author
author2 Sánchez López, Elsa
Bodega Magro, Guillermo|||0000-0003-1469-3242
Giannarelli, Chiara
Carracedo Añón, Julia María
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hypoxia-inducible factor-1alfa (HIF1alfa)
Vascular aging
Senescent cells
Endothelial cells
Vascular smooth muscle cells
Atherosclerosis
Extracellular vesicles
Medicina
Medicine
topic Hypoxia-inducible factor-1alfa (HIF1alfa)
Vascular aging
Senescent cells
Endothelial cells
Vascular smooth muscle cells
Atherosclerosis
Extracellular vesicles
Medicina
Medicine
description Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and sti ness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1 as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1 in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/51267
https://dx.doi.org/10.3390/cells9010195
url http://hdl.handle.net/10017/51267
https://dx.doi.org/10.3390/cells9010195
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ISCIII PI19%2F00240 ES
ISCIII PI17%2F01029 ES
Grupo Santander%2FUCM PR41%2F17-20964 Not available
UAH Not available GP-2018-4
UAH Not available CGC2018%2FBIO-012
UCSD Not available P30AR073761
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409065954705408
score 15,301603

Similares en LA Referencia