Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis
Chronic hepatosplenic suppurative brucellosis (CHSB) is a local reactivation of a previous brucellosis, coursing with an immunoglobulin G (IgG) and IgA secondary immunological response. The observation of two cases of CHSB with an apparent IgM response gave rise to a detailed serological study of th...
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2006 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/23472 |
| Acesso em linha: | https://hdl.handle.net/10171/23472 |
| Access Level: | acceso abierto |
| Palavra-chave: | Immunoglobulin M/biosynthesis/blood Liver Diseases/blood/immunology/microbiology/pathology Splenic Diseases/blood/immunology/microbiology/pathology |
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Secondary serological response of patients with chronic hepatosplenic suppurative brucellosisDiaz, R. (Ramón)|||/items/5326d716-1718-4b1a-adf2-64bb72a0861cAriza, J. (J.)|||/items/a4b229c8-72d1-46a6-b42b-c7fa261136f6Alberola-Gómez-Escolar, I. (Ignacio)|||/items/8149afb4-ee0b-4712-9a89-74fddaa0b789Casanova, A. (Alain)|||/items/14c75652-928c-4925-9244-9b9ee734d5e9Rubio, M. (Manuel)|||/items/3dace272-9045-427e-8f89-3b39aaa5a9dbImmunoglobulin M/biosynthesis/bloodLiver Diseases/blood/immunology/microbiology/pathologySplenic Diseases/blood/immunology/microbiology/pathologyChronic hepatosplenic suppurative brucellosis (CHSB) is a local reactivation of a previous brucellosis, coursing with an immunoglobulin G (IgG) and IgA secondary immunological response. The observation of two cases of CHSB with an apparent IgM response gave rise to a detailed serological study of three of our patients. We studied the first sample from all three patients and successive samples from two of them. In cases 1 and 2, we found samples with positive IgM lateral flow and IgM enzyme-linked immunosorbent assay results concomitantly with rheumatoid factor (RF); after absorption with anti-RF serum, these results were rendered negative. In patients 2 and 3 the diagnosis of brucellosis was delayed, because none of the test results were initially very significant. However, a clear seroconversion of IgG antibodies was observed in subsequent months; titers of the Brucellacapt and Coombs tests increased in similar ways, although Brucellacapt decreased more rapidly than Coombs, which persisted at high titers for years. In patient 3 a relapse was observed in the fourth year of follow-up, detected by Coombs and also by IgG lateral flow and counterimmunoelectrophoresis (CIEP), although not by the rose bengal, agglutination, or Brucellacapt tests. Serological changes in CHSB may sometimes be mild and are detected mainly by the Coombs test. Brucellacapt does not offer additional information, although IgG lateral flow and CIEP may be of some use. Careful surveillance of titer changes in the Coombs test is the best marker of infection activity. As the disease progresses, an intense IgG response may develop and RF sometimes appears, simulating an IgM responseAmerican Society for MicrobiologyDadun. Depósito Académico Digital Universidad de Navarra20122012-10-2320062006-01-0120062006-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/23472reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/234722026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| title |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| spellingShingle |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis Diaz, R. (Ramón)|||/items/5326d716-1718-4b1a-adf2-64bb72a0861c Immunoglobulin M/biosynthesis/blood Liver Diseases/blood/immunology/microbiology/pathology Splenic Diseases/blood/immunology/microbiology/pathology |
| title_short |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| title_full |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| title_fullStr |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| title_full_unstemmed |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| title_sort |
Secondary serological response of patients with chronic hepatosplenic suppurative brucellosis |
| dc.creator.none.fl_str_mv |
Diaz, R. (Ramón)|||/items/5326d716-1718-4b1a-adf2-64bb72a0861c Ariza, J. (J.)|||/items/a4b229c8-72d1-46a6-b42b-c7fa261136f6 Alberola-Gómez-Escolar, I. (Ignacio)|||/items/8149afb4-ee0b-4712-9a89-74fddaa0b789 Casanova, A. (Alain)|||/items/14c75652-928c-4925-9244-9b9ee734d5e9 Rubio, M. (Manuel)|||/items/3dace272-9045-427e-8f89-3b39aaa5a9db |
| author |
Diaz, R. (Ramón)|||/items/5326d716-1718-4b1a-adf2-64bb72a0861c |
| author_facet |
Diaz, R. (Ramón)|||/items/5326d716-1718-4b1a-adf2-64bb72a0861c Ariza, J. (J.)|||/items/a4b229c8-72d1-46a6-b42b-c7fa261136f6 Alberola-Gómez-Escolar, I. (Ignacio)|||/items/8149afb4-ee0b-4712-9a89-74fddaa0b789 Casanova, A. (Alain)|||/items/14c75652-928c-4925-9244-9b9ee734d5e9 Rubio, M. (Manuel)|||/items/3dace272-9045-427e-8f89-3b39aaa5a9db |
| author_role |
author |
| author2 |
Ariza, J. (J.)|||/items/a4b229c8-72d1-46a6-b42b-c7fa261136f6 Alberola-Gómez-Escolar, I. (Ignacio)|||/items/8149afb4-ee0b-4712-9a89-74fddaa0b789 Casanova, A. (Alain)|||/items/14c75652-928c-4925-9244-9b9ee734d5e9 Rubio, M. (Manuel)|||/items/3dace272-9045-427e-8f89-3b39aaa5a9db |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Immunoglobulin M/biosynthesis/blood Liver Diseases/blood/immunology/microbiology/pathology Splenic Diseases/blood/immunology/microbiology/pathology |
| topic |
Immunoglobulin M/biosynthesis/blood Liver Diseases/blood/immunology/microbiology/pathology Splenic Diseases/blood/immunology/microbiology/pathology |
| description |
Chronic hepatosplenic suppurative brucellosis (CHSB) is a local reactivation of a previous brucellosis, coursing with an immunoglobulin G (IgG) and IgA secondary immunological response. The observation of two cases of CHSB with an apparent IgM response gave rise to a detailed serological study of three of our patients. We studied the first sample from all three patients and successive samples from two of them. In cases 1 and 2, we found samples with positive IgM lateral flow and IgM enzyme-linked immunosorbent assay results concomitantly with rheumatoid factor (RF); after absorption with anti-RF serum, these results were rendered negative. In patients 2 and 3 the diagnosis of brucellosis was delayed, because none of the test results were initially very significant. However, a clear seroconversion of IgG antibodies was observed in subsequent months; titers of the Brucellacapt and Coombs tests increased in similar ways, although Brucellacapt decreased more rapidly than Coombs, which persisted at high titers for years. In patient 3 a relapse was observed in the fourth year of follow-up, detected by Coombs and also by IgG lateral flow and counterimmunoelectrophoresis (CIEP), although not by the rose bengal, agglutination, or Brucellacapt tests. Serological changes in CHSB may sometimes be mild and are detected mainly by the Coombs test. Brucellacapt does not offer additional information, although IgG lateral flow and CIEP may be of some use. Careful surveillance of titer changes in the Coombs test is the best marker of infection activity. As the disease progresses, an intense IgG response may develop and RF sometimes appears, simulating an IgM response |
| publishDate |
2006 |
| dc.date.none.fl_str_mv |
2006 2006-01-01 2006 2006-01-01 2012 2012-10-23 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/23472 |
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https://hdl.handle.net/10171/23472 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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American Society for Microbiology |
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American Society for Microbiology |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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