Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis

Background: Multiple sclerosis (MS) is an immune-mediated inflammatory disease that primarily targets the myelin of axons. Extremities are frequently affected, resulting in a negative impact on both activities of daily living (ADL) and quality of life. In recent years, there has been increasing inte...

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Autores: Blázquez Fernández, Aitor, Marcos Antón, Selena, Cano de la Cuerda, Roberto
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Villanueva (UV)
Repositorio:DIGI-UV. Repositorio Digital de la Universidad Villanueva
OAI Identifier:oai:digiuv.villanueva.edu:20.500.12766/693
Acceso en línea:https://hdl.handle.net/20.500.12766/693
Access Level:acceso abierto
Palabra clave:Multiple sclerosis
Exercise
Physical activity
Bood flow restriction training
Strength
Resistance
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spelling Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple SclerosisBlázquez Fernández, AitorMarcos Antón, SelenaCano de la Cuerda, RobertoMultiple sclerosisExercisePhysical activityBood flow restriction trainingStrengthResistanceBackground: Multiple sclerosis (MS) is an immune-mediated inflammatory disease that primarily targets the myelin of axons. Extremities are frequently affected, resulting in a negative impact on both activities of daily living (ADL) and quality of life. In recent years, there has been increasing interest in the potential benefits of exercise and blood flow restriction training (BFRT) programs as a therapeutic tool in people with neurological disorders. The aim of the present systematic review was to know the clinical effects of BFRT programs in people with MS. Methods: A systematically comprehensive literature search was conducted and registered in PROSPERO prior to its execution under the reference number CRD42024588963. The following data sources were used: Pubmed, Scopus, Web of Science (WOS) and the Cochrane Library. The following data were extracted from the papers: study design, sample, interventions, dosage, outcome measures and results. To assess the methodological quality of the papers included, the Quality Index of Downs and Black was used. Additionally, the articles were classified according to the levels of evidence and grades of recommendation for diagnosis studies established by the Oxford Center for Evidence-Based Medicine. Also, the Cochrane Handbook for Systematic Reviews of Interventions was used by two independent reviewers to assess risk of bias, assessing the six different domains. Results: Seven articles with a total of 71 participants were included in the review. Of the seven articles, five papers studied the effectiveness of BFRT combined with strengthening exercises and two papers studied the effect of BFRT combined with aerobic exercise. Of the five articles that analyzed BFRT combined with strengthening exercises, only two presented a control group. Both performed a low-load resistance training in combination with BFRT with four series, 30/15/15/15 repetitions and a rest of 1 min between the series and 3 min between the exercises. The control groups to which they were compared performed a high intensity strengthening exercise protocol which had the same exercises, sets, rests and duration of the protocol as the experimental groups. For those two papers which investigated the effects of BFRT combined with aerobic training, exercise was performed in two sessions per week for a period of 8 and 6 weeks, respectively. In both studies, the experimental protocol began with a warm-up phase and ended with a cool-down phase, and there were differences in cuff management. All these investigations found positive effects in the interventions that combined exercise with BFRT. The characteristics, outcome measures, effects of the interventions and the assessment of the methodological quality of the included studies and risk of bias are shown in the tables. Conclusions: BFRT in people with MS appears to be effective and safe for people with MS. BFRT might show positive clinical effects on strength, hypertrophy and balance outcomes. Nevertheless, future research should be conducted with better methodological quality to ensure the potential benefits of BFRT in people with MS since the studies analyzed present a high risk of bias and methodological limitations.Psicología y Ciencias de la SaludMDPI2024info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12766/693reponame:DIGI-UV. Repositorio Digital de la Universidad Villanuevainstname:Universidad Villanueva (UV)Ingléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:digiuv.villanueva.edu:20.500.12766/6932026-06-11T12:44:17Z
dc.title.none.fl_str_mv Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
title Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
spellingShingle Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
Blázquez Fernández, Aitor
Multiple sclerosis
Exercise
Physical activity
Bood flow restriction training
Strength
Resistance
title_short Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
title_full Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
title_fullStr Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
title_full_unstemmed Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
title_sort Effectiveness and Feasibility of Blood Flow Restriction Training for People with Multiple Sclerosis
dc.creator.none.fl_str_mv Blázquez Fernández, Aitor
Marcos Antón, Selena
Cano de la Cuerda, Roberto
author Blázquez Fernández, Aitor
author_facet Blázquez Fernández, Aitor
Marcos Antón, Selena
Cano de la Cuerda, Roberto
author_role author
author2 Marcos Antón, Selena
Cano de la Cuerda, Roberto
author2_role author
author
dc.subject.none.fl_str_mv Multiple sclerosis
Exercise
Physical activity
Bood flow restriction training
Strength
Resistance
topic Multiple sclerosis
Exercise
Physical activity
Bood flow restriction training
Strength
Resistance
description Background: Multiple sclerosis (MS) is an immune-mediated inflammatory disease that primarily targets the myelin of axons. Extremities are frequently affected, resulting in a negative impact on both activities of daily living (ADL) and quality of life. In recent years, there has been increasing interest in the potential benefits of exercise and blood flow restriction training (BFRT) programs as a therapeutic tool in people with neurological disorders. The aim of the present systematic review was to know the clinical effects of BFRT programs in people with MS. Methods: A systematically comprehensive literature search was conducted and registered in PROSPERO prior to its execution under the reference number CRD42024588963. The following data sources were used: Pubmed, Scopus, Web of Science (WOS) and the Cochrane Library. The following data were extracted from the papers: study design, sample, interventions, dosage, outcome measures and results. To assess the methodological quality of the papers included, the Quality Index of Downs and Black was used. Additionally, the articles were classified according to the levels of evidence and grades of recommendation for diagnosis studies established by the Oxford Center for Evidence-Based Medicine. Also, the Cochrane Handbook for Systematic Reviews of Interventions was used by two independent reviewers to assess risk of bias, assessing the six different domains. Results: Seven articles with a total of 71 participants were included in the review. Of the seven articles, five papers studied the effectiveness of BFRT combined with strengthening exercises and two papers studied the effect of BFRT combined with aerobic exercise. Of the five articles that analyzed BFRT combined with strengthening exercises, only two presented a control group. Both performed a low-load resistance training in combination with BFRT with four series, 30/15/15/15 repetitions and a rest of 1 min between the series and 3 min between the exercises. The control groups to which they were compared performed a high intensity strengthening exercise protocol which had the same exercises, sets, rests and duration of the protocol as the experimental groups. For those two papers which investigated the effects of BFRT combined with aerobic training, exercise was performed in two sessions per week for a period of 8 and 6 weeks, respectively. In both studies, the experimental protocol began with a warm-up phase and ended with a cool-down phase, and there were differences in cuff management. All these investigations found positive effects in the interventions that combined exercise with BFRT. The characteristics, outcome measures, effects of the interventions and the assessment of the methodological quality of the included studies and risk of bias are shown in the tables. Conclusions: BFRT in people with MS appears to be effective and safe for people with MS. BFRT might show positive clinical effects on strength, hypertrophy and balance outcomes. Nevertheless, future research should be conducted with better methodological quality to ensure the potential benefits of BFRT in people with MS since the studies analyzed present a high risk of bias and methodological limitations.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12766/693
url https://hdl.handle.net/20.500.12766/693
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:DIGI-UV. Repositorio Digital de la Universidad Villanueva
instname:Universidad Villanueva (UV)
instname_str Universidad Villanueva (UV)
reponame_str DIGI-UV. Repositorio Digital de la Universidad Villanueva
collection DIGI-UV. Repositorio Digital de la Universidad Villanueva
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