Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by loss of coordination, weakness, dysfunctions in bladder capacity, bowel movement, and cognitive impairment. Thus, the disease leads to a significant socioeconomic burden. In the pathophysiology of the dis...

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Detalhes bibliográficos
Autores: Celarain, Naiara, Tomàs Roig, Jordi
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/20620
Acesso em linha:http://hdl.handle.net/10256/20620
Access Level:Acceso aberto
Palavra-chave:Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
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spelling Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosisCelarain, NaiaraTomàs Roig, JordiEsclerosi múltipleEpigenèticaMultiple sclerosisEpigeneticsMultiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by loss of coordination, weakness, dysfunctions in bladder capacity, bowel movement, and cognitive impairment. Thus, the disease leads to a significant socioeconomic burden. In the pathophysiology of the disease, both genetic and environmental risk factors are involved. Gene x environment interaction is modulated by epigenetic mechanisms. Epigenetics refers to a sophisticated system that regulates gene expression with no changes in the DNA sequence. The most studied epigenetic mechanism is the DNA methylation. In this review, we summarize the data available from the current literature by grouping sets of differentially methylated genes in distinct biological categories: the immune system including innate and adaptive response, the DNA damage, and the central nervous systemThis review was funded by the Deutsche Forschungsgemeinschaft to Dr. Jordi Tomas Roig (ref. TO 977/1-1) and the University of Girona to Mrs Naiara Celarain Sanz (ref. IFUdG2017)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/20620http://hdl.handle.net/10256/20620Frontiers in Genetics, 2019, vol. 10, art.núm. 1138Articles publicats (IdIBGi)Celarain, Naiara Tomàs Roig, Jordi 2019 Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis Frontiers In Geneticsreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fgene.2019.01138info:eu-repo/semantics/altIdentifier/eissn/1664-8021Reconeixement 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/206202026-05-29T05:05:01Z
dc.title.none.fl_str_mv Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
title Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
spellingShingle Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
Celarain, Naiara
Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
title_short Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
title_full Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
title_fullStr Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
title_full_unstemmed Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
title_sort Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis
dc.creator.none.fl_str_mv Celarain, Naiara
Tomàs Roig, Jordi
author Celarain, Naiara
author_facet Celarain, Naiara
Tomàs Roig, Jordi
author_role author
author2 Tomàs Roig, Jordi
author2_role author
dc.subject.none.fl_str_mv Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
topic Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
description Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by loss of coordination, weakness, dysfunctions in bladder capacity, bowel movement, and cognitive impairment. Thus, the disease leads to a significant socioeconomic burden. In the pathophysiology of the disease, both genetic and environmental risk factors are involved. Gene x environment interaction is modulated by epigenetic mechanisms. Epigenetics refers to a sophisticated system that regulates gene expression with no changes in the DNA sequence. The most studied epigenetic mechanism is the DNA methylation. In this review, we summarize the data available from the current literature by grouping sets of differentially methylated genes in distinct biological categories: the immune system including innate and adaptive response, the DNA damage, and the central nervous system
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/20620
http://hdl.handle.net/10256/20620
url http://hdl.handle.net/10256/20620
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fgene.2019.01138
info:eu-repo/semantics/altIdentifier/eissn/1664-8021
dc.rights.none.fl_str_mv Reconeixement 4.0 Internacional
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement 4.0 Internacional
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Frontiers in Genetics, 2019, vol. 10, art.núm. 1138
Articles publicats (IdIBGi)
Celarain, Naiara Tomàs Roig, Jordi 2019 Changes in deoxyribonucleic acid methylation contribute to the pathophysiology of multiple sclerosis Frontiers In Genetics
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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