Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control

Diabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel...

ver descrição completa

Detalhes bibliográficos
Autores: Muñoz Galan, Helena|||0000-0003-2550-0047, Enshaei, Hamidreza, C. Silva, João, Esteves, Teresa, Castelo Ferreira, Frederico, Casanovas Muñoz, Jordi, Worch, Josh, Dove, Andrew, Alemán Llansó, Carlos|||0000-0003-4462-6075, Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositório:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglês
OAI Identifier:oai:upcommons.upc.edu:2117/415548
Acesso em linha:https://hdl.handle.net/2117/415548
https://dx.doi.org/10.1021/acsapm.4c00911
Access Level:Acceso aberto
Palavra-chave:Insulin--Biotechnology
Insulin--Therapeutic use--Administration
Electroactive click-hydrogel
Thiol–yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
Insulina--Biotecnologia
Insulina--Ús terapèutic--Administració
Àrees temàtiques de la UPC::Enginyeria biomèdica
id ES_5b7493f7dbbb3d87dfb6a5a17b3a01fc
oai_identifier_str oai:upcommons.upc.edu:2117/415548
network_acronym_str ES
network_name_str España
repository_id_str
spelling Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage controlMuñoz Galan, Helena|||0000-0003-2550-0047Enshaei, HamidrezaC. Silva, JoãoEsteves, TeresaCastelo Ferreira, FredericoCasanovas Muñoz, JordiWorch, JoshDove, AndrewAlemán Llansó, Carlos|||0000-0003-4462-6075Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485Insulin--BiotechnologyInsulin--Therapeutic use--AdministrationElectroactive click-hydrogelThiol–yne nucleophilic additionPEDOT nanoparticlesInsulin deliveryBioelectronicsInsulina--BiotecnologiaInsulina--Ús terapèutic--AdministracióÀrees temàtiques de la UPC::Enginyeria biomèdicaDiabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option to administrate insulin. Most importantly, the device is rendered electroactive by incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) as conductive moieties to precisely control the release of insulin over an extended period through electrochemical stimulation (ES). The device has been carefully optimized on account of: (i) the main interactions established between PEDOT- and PEG-based moieties, which have been studied by density functional theory calculations, and reveal the choice of 4-arm PEG precursors as most suitable cross-linkers; and (ii) the concentration of PEDOT NPs in the device, which has been determined considering minimal interference with the gelation process, as well as the resulting morphological, mechanical, electrochemical, and cytocompatible properties of the PEG-based click-hydrogels. Finally, the management over insulin delivery through ES is verified in vitro, with released insulin being detected by high-performance liquid chromatography. Overall, our hydrogel-based device establishes a method for controlled insulin delivery with the potential for translation to other relevant bioelectronic applications.American Chemical Society (ACS)20242024-07-1120242024-10-09journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/415548https://dx.doi.org/10.1021/acsapm.4c00911reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4155482026-05-27T15:37:01Z
dc.title.none.fl_str_mv Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
title Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
spellingShingle Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
Muñoz Galan, Helena|||0000-0003-2550-0047
Insulin--Biotechnology
Insulin--Therapeutic use--Administration
Electroactive click-hydrogel
Thiol–yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
Insulina--Biotecnologia
Insulina--Ús terapèutic--Administració
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
title_full Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
title_fullStr Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
title_full_unstemmed Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
title_sort Electroresponsive thiol-yne click-hydrogels for insulin smart delivery: tackling sustained release and leakage control
dc.creator.none.fl_str_mv Muñoz Galan, Helena|||0000-0003-2550-0047
Enshaei, Hamidreza
C. Silva, João
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Muñoz, Jordi
Worch, Josh
Dove, Andrew
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author Muñoz Galan, Helena|||0000-0003-2550-0047
author_facet Muñoz Galan, Helena|||0000-0003-2550-0047
Enshaei, Hamidreza
C. Silva, João
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Muñoz, Jordi
Worch, Josh
Dove, Andrew
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author_role author
author2 Enshaei, Hamidreza
C. Silva, João
Esteves, Teresa
Castelo Ferreira, Frederico
Casanovas Muñoz, Jordi
Worch, Josh
Dove, Andrew
Alemán Llansó, Carlos|||0000-0003-4462-6075
Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Insulin--Biotechnology
Insulin--Therapeutic use--Administration
Electroactive click-hydrogel
Thiol–yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
Insulina--Biotecnologia
Insulina--Ús terapèutic--Administració
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Insulin--Biotechnology
Insulin--Therapeutic use--Administration
Electroactive click-hydrogel
Thiol–yne nucleophilic addition
PEDOT nanoparticles
Insulin delivery
Bioelectronics
Insulina--Biotecnologia
Insulina--Ús terapèutic--Administració
Àrees temàtiques de la UPC::Enginyeria biomèdica
description Diabetes is a metabolic disorder caused by the body’s inability to produce or use insulin. Considering the figures projected by the World Health Organization, research on insulin therapy is crucial. Hence, we present a soft biointerface based on a thiol–yne poly(ethylene glycol) (PEG) click-hydrogel as an advanced treatment option to administrate insulin. Most importantly, the device is rendered electroactive by incorporating biocompatible poly(3,4-ethylenedioxythiophene) nanoparticles (PEDOT NPs) as conductive moieties to precisely control the release of insulin over an extended period through electrochemical stimulation (ES). The device has been carefully optimized on account of: (i) the main interactions established between PEDOT- and PEG-based moieties, which have been studied by density functional theory calculations, and reveal the choice of 4-arm PEG precursors as most suitable cross-linkers; and (ii) the concentration of PEDOT NPs in the device, which has been determined considering minimal interference with the gelation process, as well as the resulting morphological, mechanical, electrochemical, and cytocompatible properties of the PEG-based click-hydrogels. Finally, the management over insulin delivery through ES is verified in vitro, with released insulin being detected by high-performance liquid chromatography. Overall, our hydrogel-based device establishes a method for controlled insulin delivery with the potential for translation to other relevant bioelectronic applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-11
2024
2024-10-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/415548
https://dx.doi.org/10.1021/acsapm.4c00911
url https://hdl.handle.net/2117/415548
https://dx.doi.org/10.1021/acsapm.4c00911
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society (ACS)
publisher.none.fl_str_mv American Chemical Society (ACS)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408801003667456
score 15.811543

Registros relacionados