Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery

Background/aims: A previous study has demonstrated that endogenous male sex hormones do not alter neuronal nitric oxide (NO) release in rat mesenteric artery. However, the regulatory role of endogenous male sex hormones on noradrenaline (NA) release in rat mesenteric artery is not known. The present...

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Detalles Bibliográficos
Autores: Blanco Rivero, Javier, Aras López, Rosa, Del Campo Milán, Lara, Sagredo, Ana, Balfagón, Gloria, Ferrer, Mercedes
Tipo de recurso: artículo
Fecha de publicación:2007
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/96167
Acceso en línea:https://hdl.handle.net/20.500.14352/96167
Access Level:acceso abierto
Palabra clave:611.3
616.4
611.63/.64
β-Adrenoceptor
Neuronal nitric oxide
Noradrenaline
Orchidectomy
Mesenteric artery
Sistema cardiovascular
Endocrinología
Nefrología y urología
3207.04 Patología Cardiovascular
3205.02 Endocrinología
3213.16 Urología
id ES_5a84ad9aef530ade018564320d184fd4
oai_identifier_str oai:docta.ucm.es:20.500.14352/96167
network_acronym_str ES
network_name_str España
repository_id_str
spelling Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric arteryBlanco Rivero, JavierAras López, RosaDel Campo Milán, LaraSagredo, AnaBalfagón, GloriaFerrer, Mercedes611.3616.4611.63/.64β-AdrenoceptorNeuronal nitric oxideNoradrenalineOrchidectomyMesenteric arterySistema cardiovascularEndocrinologíaNefrología y urología3207.04 Patología Cardiovascular3205.02 Endocrinología3213.16 UrologíaBackground/aims: A previous study has demonstrated that endogenous male sex hormones do not alter neuronal nitric oxide (NO) release in rat mesenteric artery. However, the regulatory role of endogenous male sex hormones on noradrenaline (NA) release in rat mesenteric artery is not known. The present study was designed to analyze whether endogenous male sex hormones influence the NA release induced by electrical field stimulation (EFS), as well as the possible modification in NA and neuronal NO release by presynaptic beta-adrenoceptor activation. Methods: For this purpose, mesenteric arteries from control and orchidectomized male Sprague-Dawley rats were used. Basal and EFS-induced neuronal NO and NA release, as well as the contractile effect induced by EFS, was measured. Results: Basal and EFS-induced neuronal NO and NA release were similar in arteries from control and orchidectomized rats. The beta-adrenoceptor agonist clenbuterol did not modify EFS-induced neuronal NO and NA release in arteries from control rats. In contrast, in arteries from orchidectomized animals, clenbuterol increased both neuronal NO and NA release; this increase was prevented by incubation with the beta-adrenoceptor antagonist propranolol. However, the contractile response elicited by EFS was not modified by clenbuterol in either group of rats. Conclusions: These results show that orchidectomy does not alter the EFS-induced NA release. What is more, activation of presynaptic beta-adrenoceptors does not modify EFS-induced NA and neuronal NO release in arteries from control rats although it increases the release of both neurotransmitters in arteries from orchidectomized rats. Despite these modifications, the EFS-induced contractile response is preserved in arteries from orchidectomized rats.KragerUniversidad Complutense de Madrid20072007-01-1720072007-01-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/96167reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMISAN Fondo de Investigaciones Sanitarias PI051767Fundación de Investigación Médica Mutua Not available FMM-06Dirección General de Ciencias y Tecnología SAF2005-05760 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/961672026-06-02T12:44:21Z
dc.title.none.fl_str_mv Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
title Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
spellingShingle Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
Blanco Rivero, Javier
611.3
616.4
611.63/.64
β-Adrenoceptor
Neuronal nitric oxide
Noradrenaline
Orchidectomy
Mesenteric artery
Sistema cardiovascular
Endocrinología
Nefrología y urología
3207.04 Patología Cardiovascular
3205.02 Endocrinología
3213.16 Urología
title_short Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
title_full Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
title_fullStr Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
title_full_unstemmed Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
title_sort Orchidectomy increases beta-adrenoceptor activation-mediated neuronal nitric oxide and noradrenaline release in rat mesenteric artery
dc.creator.none.fl_str_mv Blanco Rivero, Javier
Aras López, Rosa
Del Campo Milán, Lara
Sagredo, Ana
Balfagón, Gloria
Ferrer, Mercedes
author Blanco Rivero, Javier
author_facet Blanco Rivero, Javier
Aras López, Rosa
Del Campo Milán, Lara
Sagredo, Ana
Balfagón, Gloria
Ferrer, Mercedes
author_role author
author2 Aras López, Rosa
Del Campo Milán, Lara
Sagredo, Ana
Balfagón, Gloria
Ferrer, Mercedes
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.3
616.4
611.63/.64
β-Adrenoceptor
Neuronal nitric oxide
Noradrenaline
Orchidectomy
Mesenteric artery
Sistema cardiovascular
Endocrinología
Nefrología y urología
3207.04 Patología Cardiovascular
3205.02 Endocrinología
3213.16 Urología
topic 611.3
616.4
611.63/.64
β-Adrenoceptor
Neuronal nitric oxide
Noradrenaline
Orchidectomy
Mesenteric artery
Sistema cardiovascular
Endocrinología
Nefrología y urología
3207.04 Patología Cardiovascular
3205.02 Endocrinología
3213.16 Urología
description Background/aims: A previous study has demonstrated that endogenous male sex hormones do not alter neuronal nitric oxide (NO) release in rat mesenteric artery. However, the regulatory role of endogenous male sex hormones on noradrenaline (NA) release in rat mesenteric artery is not known. The present study was designed to analyze whether endogenous male sex hormones influence the NA release induced by electrical field stimulation (EFS), as well as the possible modification in NA and neuronal NO release by presynaptic beta-adrenoceptor activation. Methods: For this purpose, mesenteric arteries from control and orchidectomized male Sprague-Dawley rats were used. Basal and EFS-induced neuronal NO and NA release, as well as the contractile effect induced by EFS, was measured. Results: Basal and EFS-induced neuronal NO and NA release were similar in arteries from control and orchidectomized rats. The beta-adrenoceptor agonist clenbuterol did not modify EFS-induced neuronal NO and NA release in arteries from control rats. In contrast, in arteries from orchidectomized animals, clenbuterol increased both neuronal NO and NA release; this increase was prevented by incubation with the beta-adrenoceptor antagonist propranolol. However, the contractile response elicited by EFS was not modified by clenbuterol in either group of rats. Conclusions: These results show that orchidectomy does not alter the EFS-induced NA release. What is more, activation of presynaptic beta-adrenoceptors does not modify EFS-induced NA and neuronal NO release in arteries from control rats although it increases the release of both neurotransmitters in arteries from orchidectomized rats. Despite these modifications, the EFS-induced contractile response is preserved in arteries from orchidectomized rats.
publishDate 2007
dc.date.none.fl_str_mv 2007
2007-01-17
2007
2007-01-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/96167
url https://hdl.handle.net/20.500.14352/96167
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv MISAN Fondo de Investigaciones Sanitarias PI051767
Fundación de Investigación Médica Mutua Not available FMM-06
Dirección General de Ciencias y Tecnología SAF2005-05760 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Krager
publisher.none.fl_str_mv Krager
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408712780677120
score 15,300724

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